Publications by authors named "Guang-You Chen"
Despite substantial progress in clinical trials of osteoarthritis (OA) gene therapy, the prevalence of OA is still on the rise. MiRNAs have a potential biomarker and therapeutic target for OA. OA cartilage and chondrosarcoma cells were studied to determine the role of miR-29a-3p and PTEN.
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- Carboxylesterases (CarEs) are important for detoxifying harmful chemicals, which may relate to insecticide resistance in pests like Helicoverpa armigera.
- Seven mutants of CarE 001C were created to study how single amino acid changes affect enzyme activity.
- Two specific mutations, H423I and R322L, enhanced the enzyme's ability to metabolize fenvalerate, indicating potential avenues for understanding resistance mechanisms in these agricultural pests.