Publications by authors named "Guang-Xue He"
Article Synopsis
- Tuberculosis (TB) remains a significant public health challenge in China, with a study analyzing TB incidence from 2014 to 2021 to better understand its epidemiology and inform prevention strategies.
- The research utilized a sophisticated two-stage distributed lag nonlinear model to assess the influence of meteorological factors on TB rates, alongside demographic, healthcare, and economic factors using spatial panel data models.
- Findings revealed a decrease in TB incidence from 67.05 to 46.40 cases per 100,000 from 2014 to 2021, with higher rates among males, farmers, and older adults, as well as a notable impact from specific meteorological conditions on TB risk.
Article Synopsis
- The study examines the incidence of seven respiratory infectious diseases (RIDs) in mainland China from 2017 to 2021 to improve public health strategies.
- A total of 11,963,886 cases were reported, with seasonal influenza having the highest average incidence rate, and males showed higher rates across all diseases.
- Notably, tuberculosis rates were highest among farmers and those over 65, while other RIDs affected mostly children; incidences of PTB and measles declined, whereas the other RIDs peaked in 2019.
Article Synopsis
- The study investigates the genotyping features of human fecal strains and the link between antibiotic resistance genes (ARGs) and multidrug resistance (MDR) in a Beijing district known for high rates of infectious diarrhea.
- Over three years, researchers isolated 94 strains from fecal samples, assessing antibiotic susceptibility and analyzing genetic data through whole-genome sequencing.
- Findings showed a high prevalence of MDR among the isolates, with similar rates in both diarrheal and healthy individuals, and the study suggests ongoing monitoring of ARGs and MDR is necessary for improving predictions and understanding the transmission of resistance genes.
[Main Infection Control Measures for Respiratory Infectious Diseases in Medical Institutions and Public Places in China].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
April 2023
Article Synopsis
- Respiratory infectious diseases (RID) pose significant public health threats, and effective infection control (IC) is crucial for managing their spread.
- A review of literature since 2018 highlighted achievements, problems, and challenges in IC across various levels of medical institutions in China, showing inconsistent efforts in different regions.
- Recommendations include better application of existing IC tools, the development of advanced technology for new IC products, and the establishment of a digital platform for monitoring and managing infections to enhance IC measures.
Article Synopsis
- The study investigates how globalization and increased international travel contribute to the importation of respiratory infectious diseases (RIDs) in China, using data from 2014 to 2018.
- It found that over 31,000 cases of imported RIDs were reported during this period, mostly comprised of influenza, with a notable increase in incidence rates over the years.
- The findings highlight the need for enhanced surveillance and high-tech methods to detect and prevent the spread of imported RIDs to safeguard public health in China.
Background: COVID-19 has posed an enormous threat to public health around the world. Some severe and critical cases have bad prognoses and high case fatality rates, unraveling risk factors for severe COVID-19 are of significance for predicting and preventing illness progression, and reducing case fatality rates. Our study focused on analyzing characteristics of COVID-19 cases and exploring risk factors for developing severe COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes notifiable infectious diseases in foreign nationals in China from 2004 to 2017, using data from the National Notifiable Infectious Disease Reporting System.
- A total of 67,939 cases across 33 diseases were reported, with HIV, hepatitis B, and hand, foot, and mouth disease showing the highest incidences, particularly in Yunnan province.
- The findings aim to enhance public health policy and responses by providing key epidemiological insights for future research and health strategies in China.
Article Synopsis
- The study focused on the genetic diversity of Mycobacterium tuberculosis (MTB) in a remote mountainous region of southwest China, looking specifically at the Beijing family strains and their association with drug resistance.
- Researchers analyzed 331 MTB strains using SNP and VNTR genotyping, finding that 55.29% belonged to the Beijing family, with 60.66% of those being modern strains.
- Results indicated a significant prevalence of multi-drug resistant tuberculosis (MDR-TB) within the Beijing lineage, along with certain drug resistances, while genetic clustering was not linked to drug resistance, demonstrating the complex nature of MTB in this region.
Article Synopsis
- * Risk factors linked to higher TB rates included older age (51+ years), being a nurse, and inadequate infection control and ventilation measures at healthcare facilities.
- * The results highlight poor TB infection control practices in some facilities, indicating a need for improved measures to protect HCWs and reduce TB prevalence in this high-risk group.
Objective: Mycobacterium avium (M. avium) and Mycobacterium intracellulare (M. intracellulare) are the major causative agents of nontuberculous mycobacteria (NTM)-related pulmonary infections.
View Article and Find Full Text PDFWe performed molecular identification of clinical isolates of Mycobacterium fortuitum (M. fortuitum) and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs.
View Article and Find Full Text PDFThis study aimed to learn the recurrence rate in the retreatment TB patients with sputum smear and/or culture positive (ss+ and/or c+) two years after they were declared cured, and to explore causes of recurrence in order to improve long-time treatment outcome. 5 cities were selected as research locations. Recurrence of TB was judged by chest X-ray examination together with sputum smear and culture examination.
View Article and Find Full Text PDF[Analysis on the spatial clustering of tuberculosis based on provincial level in China from 2008 to 2010].
Zhonghua Liu Xing Bing Xue Za Zhi
February 2013
Objective: To study the tuberculosis clustering areas and the changing trend, from 2008 to 2010, so as to provider the reference for tuberculosis control.
Methods: Global spatial autocorrelation and SaTScan methods were used to detect and analyse the spatial clustering of total tuberculosis notification rate and the new smear-positive pulmonary tuberculosis notification rate, at the provincial level from 2008 to 2010.
Results: The spatial clustering (SC) phenomenon was significant on total notification rate and new smear-positive pulmonary tuberculosis notification rate from 2008 to 2010 (P < 0.
We conducted a case-control study to investigate risk factors for multidrug-resistant tuberculosis (MDR TB) in the People's Republic of China. Genotyping analysis was used to estimate the percentage of cases from recent transmission among 100 MDR TB case-patients hospitalized during April 2007-July 2009. Molecular subtyping of isolates showed that 41% of MDR TB strains clustered.
View Article and Find Full Text PDFThis investigation of tuberculosis (TB) treatment regimens in 6 TB hospitals in China showed that only 18% of patients with new cases and 9% of patients with retreatment cases were prescribed standard TB treatment regimens. Adherence to treatment guidelines needs to be improved in TB hospitals to control multidrug-resistant TB in China.
View Article and Find Full Text PDFBackground: Hospitals with inadequate infection control are risky environments for the emergence and transmission of tuberculosis (TB). We evaluated TB infection control practices, and the prevalence of latent TB infection (LTBI) and TB disease and risk factors in health care workers (HCW) in TB centers in Henan province in China.
Methods: A cross-sectional survey was conducted in 2005.
Background: In 2004, an anti-tuberculosis (TB) drug resistance survey in Heilongjiang province, China, enrolled 1574 (79%) new and 421 (21%) retreatment patients. Multi-drug resistant (MDR) TB was detected in 7.2% of new and 30.
View Article and Find Full Text PDFBackground: The emergence of drug-resistant tuberculosis (TB) hampers TB control. Ten provinces in China performed drug resistance surveys among tuberculosis (TB) patients in 1996-2004 to assess levels of drug resistance.
Methods: Provincial drug resistance surveys included all isolates from newly diagnosed, smear-positive TB patients.