Publications by authors named "Guang-Xu Deng"
Clin Sci (Lond)
March 2023
Article Synopsis
- The study investigates the role of circular RNA (circRBM23) in the differentiation of mesenchymal stem cells (MSCs) between bone-forming (osteogenic) and fat-forming (adipogenic) lineages, highlighting its link to osteoporosis (OP).
- CircRBM23 is found to be down-regulated in OP patients, and when overexpressed, it promotes bone formation while inhibiting fat cell development by interacting with microRNA-338-3p.
- The findings suggest that circRBM23 could serve as a potential target for therapies aimed at reversing the differentiation imbalance in MSCs associated with osteoporosis.
