A salicylaldehyde benzoyl hydrazone based near-infrared probe for copper(ii) and its bioimaging applications.

Developing highly sensitive and selective methods for Cu detection in living systems is of great significance in clinical copper-related disease diagnosis. In this work, a near infrared (NIR) fluorescent probe, CySBH, with a salicylaldehyde benzoyl hydrazone group as a selective and sensitive receptor for Cu was designed and synthesized. The specific coordination of the salicylaldehyde benzoyl hydrazone group in CySBH with Cu can induce a distinct quench of the fluorescence intensity, allowing for real-time tracking of Cu.