Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation.

1. The transcription factors of the NF-kappaB/Rel family form dimeric complexes that control expression of various genes involved in inflammation and proliferation. 2.

The Listeria protein internalin B mimics hepatocyte growth factor-induced receptor trafficking.

Increased hepatocyte growth factor receptor (HGFR) signaling correlates closely with neoplastic invasion and metastatic potential of many human cancers. Hepatocyte growth factor receptor signaling is initiated by binding the physiological ligand HGF or the internalin B (InlB) protein of Listeria monocytogenes. Subsequent degradation of endocytosed HGFR terminates receptor signaling.