Serum CXCL12 concentration in patients with severe traumatic brain injury are associated with mortality.

Background: CXC chemokine ligand-12 (CXCL12) is released during brain injury. The objective of this study was to investigate relationship between serum CXCL12 concentration, mortality and trauma severity in patients with traumatic brain injury (TBI).

Methods: We determined serum CXCL12 concentration of 132 controls and 132 patients with severe TBI.