Publications by authors named "Guang-Qiang Sun"
Article Synopsis
- Gliomas are challenging cancers to treat, with a very low 5-year survival rate, and Polyphyllin II, a saponin from Paris polyphylla, has not been studied for its effects on glioma cells.
- This study aimed to assess whether Polyphyllin II inhibits the growth and aggression of glioma cells (U87 and U251) and to uncover the underlying mechanisms.
- Results showed that Polyphyllin II effectively reduced cell proliferation and induced apoptosis by affecting various proteins involved in cell death pathways, suggesting it could be a potential therapeutic agent for gliomas.
Many glioma patients develop resistance to temozolomide (TMZ) treatment, resulting in reduced efficacy and survival rates. TMZ-resistant cell lines SHG44R and U87R, which highly express O -methylguanine DNA methyltransferase (MGMT) and P-gp, were established. CN-3, a new asterosaponin, showed cytotoxic effects on TMZ-resistant cells in a dose- and time-dependent manner via reactive oxygen species (ROS)-mediated apoptosis and autophagy.
View Article and Find Full Text PDFRecently we isolated CN-3, a new asterosaponin from starfish , and reported that asterosaponin arrests glioma cell cycle via SCUBE3. However, the multiple mechanisms underlying CN-3 anti-glioma action remains poorly known. Thus, the focus of this study was to evaluate the inhibitory effect of CN-3 on human glioma cells and its underlying molecular mechanisms.
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