Publications by authors named "Guang-Qian Pei"
As a key supporting technology in the fields of life sciences and medicine, high-throughput sequencing has developed rapidly and become increasingly mature. The workflow of this technology can be divided into nucleic acid extraction, library construction, sequencing, and data analysis. Among these, library construction is a pivotal step that bridges the previous and subsequent stages.
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- SARS-CoV-2 variants, including Alpha, Beta, and Delta, are still emerging and competing for dominance in various cell types, revealing distinct competitive advantages depending on the environment.
- The study demonstrated that the Beta variant thrived in Caco-2 cells, while the wild type and Alpha were more fit in Vero E6 cells; high neutralizing antibody levels altered these fitness dynamics.
- Researchers also discovered that homologous recombination occurred among variants during experiments, particularly in a specific genomic region, showing how immune pressure impacts the genetic evolution of SARS-CoV-2.
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection. Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown.
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- Cross-species virus transmission from wildlife, especially bats, poses a significant danger to human and animal health, as highlighted by the SARS outbreak linked to bats.
- * A novel bat coronavirus, SADS-CoV, has been implicated in a major outbreak that caused the deaths of nearly 25,000 piglets across multiple farms in China, notably close to where SARS originated.
- * The study indicates a close genetic relationship between SADS-CoV and other coronaviruses found in bats, emphasizing the need for ongoing monitoring of viral diversity in bat populations to prevent future health crises.
We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.
View Article and Find Full Text PDFUnlabelled: Over the course of two waves of infection, H7N9 avian influenza A virus has caused 436 human infections and claimed 170 lives in China as of July 2014. To investigate the prevalence and genetic diversity of H7N9, we surveyed avian influenza viruses in poultry in Jiangsu province within the outbreak epicenter. We found frequent occurrence of H7N9/H9N2 coinfection in chickens.
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