Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells.

Background: A large number of studies have shown that leptin plays an important role in the regulation of fertility via the hypothalamus-pituitary-gonad axis. However, its peripheral function in epididymis was still elusive.

Objective: The purpose of this study was to determine the pro-secretion effect of leptin on the rat epididymal epithelium.