Synthesis of -Vinyl Cinnamaldehyde Nitrones through Atropisomeric Quinoxaline-Derived ,,-Ligand-Promoted Chan-Lam Reaction.

A type of quinoxaline-derived tridentate ,,-ligand was synthesized in good to excellent yields over three steps through iodination of 2-aryl indoles, sequential Kornblum-type oxidation with DMSO, and capture by 1,2-diaminobenzenes. The prepared atropisomeric ,,-ligand was successfully applied in the synthesis of -vinyl cinnamaldehyde nitrones as only -isomers in good yields through the Chan-Lam reaction. The method features an easily accessed tunable tridentate ,,-ligand, broad substrate scope, good functional group tolerance, and high -isomer for -vinyl nitrones.

Cinchonidine-Catalyzed Synthesis of Oxazabicyclo[4.2.1]nonanones from -Aryl--unsaturated Nitrones and 1-Ethynylnaphthalen-2-ols.

A variety of oxazabicyclo[4.2.1]nonanone derivatives were prepared in good yields through a cinchonidine-catalyzed cascade reaction of -aryl-α,β-unsaturated nitrones and 1-ethynylnaphthalen-2-ols.

Validation and implementation of Planova™ BioEX virus filters in the manufacture of a new liquid intravenous immunoglobulin in China.

There is a continuous need to improve the viral safety of plasma products, and we here report the development and optimization of a manufacturing-scale virus removal nanofiltration step for intravenous immunoglobulin (IVIG) using the recently introduced Planova™ BioEX filter. IVIG throughput was examined for various operating parameters: transmembrane pressure, temperature, protein concentration, and prefiltration methods. The developed procedure was based on filtering undiluted process solution (50.

Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin.

Alzheimer's disease (AD) is characterized by memory loss, intracellular neurofibrillary tangles, and extracellular plaque deposits composed of β-amyloid (Aβ). Previous reports showed that naturally occurring autoantibodies, such as intravenous immunoglobulin (IVIG), benefited patients with moderate-stage AD who carried an APOE-ε4 allele. However, the mechanism underlying the role of IVIG remains unclear.