Three new sesquiterpene lactones from the whole plants of .

Three new sesquiterpene lactones, named scabertopinolides H - J (-), along with four known ones, desacylisodeoxyelephantopin 2-methylbutyrate (), iso-17,19-dihydrodeoxyelephantopin (), scabertopinolide D () and 6,7,8)-8-tigloyloxy-1(10),4(5),11(13)-germacratrien-2,15,6,12-diolide () were isolated from the whole plants of . Their structures were elucidated by extensive analysis of spectroscopic data (including IR, UV, HRESIMS, 1 D and 2 D NMR) and single-crystal X-ray. These isolated compounds showed effective anti-inflammatory effects on LPS-stimulated RAW 264.

One new sesquiterpene pyridine alkaloid from the stems and leaves of .

A new sesquiterpene pyridine alkaloid (), along with four known compounds (-), were isolated from the stems and leaves of . The new structure was determined by extensive spectroscopic analyses (IR, UV, NMR, HRESIMS and ECD). In addition, compound showed a stronger anti-respiratory syncytial virus (RSV) activity with an IC value of 1.

Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from and their cytotoxic activities.

Six new compounds, hyperpatulones A-F (1-6), along with ten additional known related derivatives (7-16), were isolated from (Guttiferae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR), X-ray crystallography, electronic circular dichroism (ECD) spectroscopy and Rh(OCOCF)-induced ECD. All compounds were tested for their cytotoxic activities on human HepG-2, HeLa, MCF-7, and A549 cell lines 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus.

Eight new matrine-type alkaloids, flavesines G-J (1-4), alopecurine B (5), 7,11-dehydro-oxymatrine (6), 10-oxy-5,6-dehydromatrine (7), and 10-oxysophoridine (8), along with nine known analogues (9-17) were isolated from the roots of Sophora flavescens. Compounds 1-3 are the first natural matrine-type alkaloids with an open-loop ring D, while compound 4 represents an unprecedented dimerization pattern constructed from matrine and piperidine, and 5 is the first example of a matrine-type alkaloid with cleavage of the C-5-C-6 bond. The new structures were elucidated by means of spectroscopic data analysis (including NMR, MS, IR, and UV), and the absolute configurations were determined using single-crystal X-ray diffraction and ECD data.