Dabigatran-induced chronic progressive immune hemolytic anemia: A case report.

Dabigatran is an orally active direct thrombin inhibitor, initially approved by FDA for the prophylaxis of stroke and systemic embolism in the setting of non-valvular atrial fibrillation (NVAF). Major bleeding is its most common adverse event which is of great concern. However, other types of adverse events such as esophagitis, esophageal ulcer, exanthem and pustular eruptions were reported increasingly in recent years.

Telmisartan attenuates hydrogen peroxide-induced apoptosis in differentiated PC12 cells.

The present study investigated the protective actions of telmisartan, an angiotensin II type 1 receptor blocker (ARBs), against the cell apoptosis induced by exposure to hydrogen peroxide (HO) in differentiated PC12 cells. Preincubation of PC12 cells with telmisartan prevented HO-induced cytotoxicity as indicated by increased MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction, decreased lactate dehydrogenase (LDH) release, and improved morphological changes. Hoechst 33,258 staining showed that telmisartan markedly reduced shrunken nuclei of the cells, and Western blot analysis indicated that telmisartan significantly attenuated caspase-3 activity, as indicated by decreased ratio of cleaved Caspase-3 to its precursor and increased ratio of Bcl-2/Bax.

Typical Application of Sound Field in Wastewater Treatment with Fluidized Bed Photocatalytic Reactor.

The effect of a sound field on wastewater treatment with a fluidized bed photocatalytic reactor (FBPR) was investigated. With Alizarin Green (AG) being the sole infectant, the Fe-doped TiO2 catalyst prepared was used as the fluidized media. According to the Langmuir-Hinshelwood model, the photocatalytic degradation follows the pseudo-first-order reaction kinetics with respect to the concentration of AG.

Telmisartan treatment ameliorates memory deficits in streptozotocin-induced diabetic mice via attenuating cerebral amyloidosis.

Telmisartan, an angiotensin II type 1-receptor blocker (ARBs), has been reported to exert beneficial effects on the central nervous system (CNS). However, the effect of telmisartan on cognitive impairment associated with type 1 diabetes is not well known. Here, we examined the possibility that telmisartan could improve memory function in a type 1 diabetic mouse model, streptozotocin (STZ)-induced diabetic mice.

3-(4-Carb-oxy-5-carboxyl-ato-1H-imidazol-2-yl)pyridin-1-ium monohydrate.

In the zwitterionic mol-ecule of the title compound, C(10)H(7)N(3)O(4)·H(2)O, one carboxyl group is deprotonated and the pyridine N atom is protonated. The pyridinium and imidazole rings form a dihedral angle of 5.23 (1)°.

[Clinical study of single-dose of recombinant humanized anti-CD3 monoclonal antibody injection in kidney transplant recipients].

Objective: To evaluate short-term and long-term safety of using single-dose escalation of recombinant humanized anti-CD3 monoclonal antibody (OKT3) in kidney transplantation recipients.

Methods: A total of 29 recipients of cadaveric kidney transplant from June 2008 to December 2008 were sequently assigned to receive single-dose intravenous injection of OKT3 with different doses of 2.5 mg (n = 9), 5.

[Imaging diagnosis of thyroid carcinoma with bone metastasis].

Objective: To study the clinical and imaging features of thyroid carcinoma with bone metastasis and evaluate the importance of the imaging diagnosis in such cases.

Methods: A retrospective analysis was performed on the results of X-ray and CT examinations of 10 pathologically confirmed patients (including 2 men and 8 women aged from 40 to 89 years with a mean age of 61 years) with thyroid carcinoma with bone metastasis.

Results: Thyroid carcinoma was latent in terms of its disease history.

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.

Oxidative damage to mitochondrial DNA (mtDNA) increases with age in the brain and can induce G:C to T:A and T:A to G:C point mutations. Though rare at any particular site, multiple somatic mtDNA mutations induced by oxidative damage or by other mechanisms may accumulate with age in the brain and thus could play a role in aging and neurodegenerative diseases. However, no prior study has quantified the total burden of mtDNA point mutation subtypes in the brain.

[Mammographic findings of gynecomastia].

Objective: To investigate the features of gynecomastia displayed by mammography.

Methods: Twelve patients with gynecomastia were examined with a high-performance GITTO-TECH mammograph (IMS Company, Italy), and the results were compared with those obtained from pathological examination.

Results: The 12 cases were pathologically confirmed as gynecomastia, 10 of which were also identified by mammography while 2 misdiagnosed as male breast cancer.