Novel intercellular spread mode of respiratory syncytial virus contributes to neutralization escape.

Developing widely used respiratory syncytial virus (RSV) vaccines remains a significant challenge, despite the recent authorization of two pre-F vaccines for elderly adults. Previous reports have suggested that even when vaccine-induced immunity generates high titers of potent neutralizing antibodies targeting the pre-F protein, it may not fully inhibit breakthrough of RSV infections. This incomplete inhibition of RSV breakthrough infections can lead to an increased risk of enhanced respiratory disease (ERD) in vaccinated individuals.

The Optimal Concentration of Formaldehyde is Key to Stabilizing the Pre-Fusion Conformation of Respiratory Syncytial Virus Fusion Protein.

Background: To date, there is no licensed vaccine available to prevent respiratory syncytial virus (RSV) infection. The valuable pre-fusion conformation of the fusion protein (pre-F) is prone to lose high neutralizing antigenic sites. The goals of this study were to stabilize pre-F protein by fixatives and try to find the possibility of developing an inactivated RSV vaccine.

Neuropective constituents from the rhizomes of Abacopteris penangiana.

Two neuropective compounds were isolated from the rhizomes of Abacopteris penangiana, one was a new flavone and the other was a flavanone. Both compounds were firstly separated from natural plant. The isolation work was guided by the antioxidant activity.

[Preliminary study on the efficacy and safety of oral sildenafil in pulmonary arterial hypertension in China].

Objective: Sildenafil has been shown to be effective in pulmonary arterial hypertension (PAH). However, the impact of sildenafil on PAH has been under-investigated in China. The aim of the present study was to evaluate the efficacy and safety of oral sildenafil in PAH patients in China.

Parathelypteriside attenuates cognition deficits in d-galactose treated mice by increasing antioxidant capacity and improving long-term potentiation.

Parathelypteriside (PG), a stilbenoid compound, was extracted from Parathelypteris glanduligera (kze.) ching that exhibits antioxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effect of PG against the d-galactose (d-gal)-induced neurotoxicity in mice.

Impact of sildenafil therapy on pulmonary arterial hypertension in adults with congenital heart disease.

Background: It has been demonstrated that sildenafil is effective in patients with pulmonary arterial hypertension (PAH). However, the impact of sildenafil on PAH in adults with congenital heart disease (CHD) has been less investigated.

Objective: In this prospective, open-label, uncontrolled and multicenter study, 60 patients with PAH related to CHD received oral sildenafil (75 mg/day) for 12 weeks.

[Effect of temperature and denitrifying phosphorus on nitrogen and phosphorous removal in SBMBBR].

The effect of two kinds of temperature conditions (14 degrees C +/- 1 degrees C and 24 degrees C +/- 1 degrees C) on the removal of phosphorus and nitrogen were studied in a sequencing batch moving bed biofilm reactor (SBMBBR). The experiments were performed at the concentrations of COD, nitrogen and phosphorus in the feed fixing at about 450 mg/L, 40 mg/L and 10 mg/L, respectively. The results indicated that under the two temperatures the phosphorus release amounts were 54.

[Detection of hantaan virus from gamasid mite and chigger mite by molecular biological methods].

Objective: To study the proliferation and location of hantaan virus (HV) in gamasid mites and chigger mites.

Methods: HV RNA in gamasid mites and chigger mites were detected by reverse transcription, polymerase chain reaction (RT- PCR) and in situ hybridization.

Results: The smallest quantity of mite from which HV RNA could be detected was 5 mites group.