Publications by authors named "Guang-Hong Ruan"
Introduction: Renal interstitial fibrosis (RIF) is a significant cause of end-stage renal failure. The goal of this study was to characterize the distribution of transplanted induced autologous stem cells in a rabbit model of renal interstitial fibrosis and evaluate its therapeutic efficacy for treatment of renal interstitial fibrosis.
Methods: A rabbit model of renal interstitial fibrosis was established.
Article Synopsis
- Induced multipotent stem (iMS) cells can be created from somatic cells through genetic or epigenetic modifications, and fish oocyte extracts (FOE) have previously been shown to successfully induce skin fibroblast cells into iMS cells.
- This study explores whether FOE can also induce mouse peripheral blood mononuclear cells (PBMCs) into the iMS state and assesses their survival after transplantation into irradiated female mice.
- Results indicated that FOE-induced PBMCs not only exhibited stem cell markers but also led to significantly higher spleen wet weights and colony counts in the recipient mice, with the presence of Y chromosomes confirming the survival of the transplanted cells.
Article Synopsis
- The study explored the impact of induced autologous stem cells on blood sugar levels in rabbits with type 1 diabetes by transplanting dedifferentiated fibroblasts into the pancreatic artery.
- After four weeks, the treatment group showed significantly lower blood glucose levels and increased plasma insulin and C-peptide levels, indicating improved pancreatic function.
- The morphological analysis revealed that induced stem cells led to changes in islet cell structure, with better preservation and function compared to the non-induced treatment group and control group, suggesting potential for diabetes therapy.
The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological scores of the treated rats and the distribution of the transplanted cells (GFP-labeled) in the infarction area were evaluated. The cerebral infarction model was produced by inserting a modified Zea-longa suture, which generated middle cerebral artery occlusion (MCAO).
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