Publications by authors named "Guang-Cheng Ding"
Objective: To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.
Methods: Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI.
Results: According to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers.
Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers.
World J Gastroenterol
December 2010
Article Synopsis
- The study aimed to explore the link between HPV infection and concurrent esophagus and gastric cardia cancers while assessing P16(INK4A) protein expression.
- Using PCR, researchers detected HPV type 16 in various cancer specimens, finding it present in 47% of esophageal cancers and 29% of gastric cancers.
- The findings suggest HPV16 may contribute to the development of these cancers, with higher levels of P16(INK4A) expression observed in gastric cardia adenocarcinoma compared to esophageal squamous cell carcinoma.
Article Synopsis
- A genome-wide association study was conducted on esophageal squamous cell carcinoma (ESCC) involving 1,077 ESCC patients and 1,733 control subjects, focusing on the Chinese Han population.
- The study successfully replicated findings in larger cohorts, identifying two new genetic risk factors for ESCC: PLCE1 and C20orf54, with strong statistical significance.
- PLCE1 is linked to essential cellular functions like growth and apoptosis, while C20orf54 is involved in riboflavin transport, highlighting their potential roles in ESCC and gastric cardia adenocarcinoma (GCA) risk.