Publications by authors named "Guang Zhu"

Sodium-ion batteries (SIBs) are a promising electrochemical energy storage system but face great challenges in developing fast-charging anodes. MXene-based composites are a new class of two-dimensional materials that are expected to be widely used in SIB energy storage due to their excellent electrical conductivity and stable structure. However, MXenes tend to experience interlayer stacking during preparation, which can result in poor electrochemical performance and a lower actual capacity compared to the theoretical value.

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G-quadruplexes (G4s) are unique nucleic acid structures composed of guanine-rich (G-rich) sequences that can form diverse topologies based on the arrangement of their four strands. G4s have attracted attention for their potential roles in various biological processes and human diseases. In this review, we focus on the G4 structures formed by human telomeric sequences, (GGGTTA), and the hexanucleotide repeat expansion, (GGGGCC), in the first intron region of the chromosome 9 open reading frame 72 () gene, highlighting their structural diversity and biological significance.

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Triboelectric nanogenerators (TENGs), among the most simple and efficient means to harvest mechanical energy, have great potential in renewable energy utilization. While the output performance of TENGs is still not high enough, which limits its practical application. Here, a poly(vinylidene fluoride) (PVDF)/fluorinated ethylene propylene nanoparticles (FEP NPs) porous nanofiber (PFPN) membrane with waterproof, breathable, surface superhydrophobic and high tribo-negative properties is proposed for achieving high-performance of TENGs.

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Objective: The pathological mechanism of osteoporosis (OP) involves increased bone resorption mediated by osteoclasts and decreased bone formation mediated by osteoblasts, leading to an imbalance in bone homeostasis. Identifying key molecules in osteoclast-mediated OP progression is crucial for the prevention and treatment of OP.

Methods: Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed on the OP patient datasets from the GEO database.

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An increasing body of evidence suggests that acylphosphatase-2 (ACYP2) polymorphisms are correlated with an increased susceptibility to a range of malignancies. Nevertheless, its potential functions, molecular mechanisms in hepatocellular carcinoma (HCC) and whether it can be act as a therapeutic target remain uninvestigated. Herein, ACYP2 was found to be lowly expressed in HCC and was negatively correlated with tumor size, tumor differentiation, microvascular invasion and the prognosis of HCC patients.

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Sodium-ion batteries (SIBs) are a promising substitute for lithium batteries due to their abundant resources and low cost. Metal sulfides are regarded as highly attractive anode materials due to their superior mechanical stability and high theoretical specific capacity. Guided by the density functional theory (DFT) calculations, 3D porous network shaped SbS/FeS composite materials with reduced graphene oxide (rGO) through a simple solvothermal and calcination method, which is predicted to facilitate favorable Na ion diffusion, is synthesized.

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Article Synopsis
  • Rhabdophis nuchalis, a snake found in China, has unique nucho-dorsal glands that make it interesting for studying genetic diversity and evolution.
  • Researchers created a high-quality reference genome for this snake using various sequencing techniques, resulting in a 1.92 Gb genome organized into 20 chromosomes.
  • The study identified over 22,000 protein-coding genes and extensive repetitive sequences, providing valuable data for understanding the species' genetics, evolution, and conservation efforts.
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Background: Schizophrenia (SCZ) patients undergoing antipsychotic treatment demonstrated a high prevalence and harmful effects of metabolic syndrome (MetS), which acted as the major cause of cardiovascular disease. The major clinical challenge is the lack of biomarkers to identify MetS episodes and prevent further damage, while the mechanisms underlying these drug-induced MetS remain unknown.

Methods: This study divided 173 participants with SCZ into 3 groups (None, High risk, and MetS, consisting of 22, 88, and 63 participants, respectively).

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The interaction between lattice vibrations and electrons plays a key role in various aspects of condensed matter physics - including electron hydrodynamics, strange metal behavior, and high-temperature superconductivity. In this study, we present systematic investigations using Raman scattering and angle-resolved photoemission spectroscopy (ARPES) to examine the phononic and electronic subsystems of the topological superconductor candidate 2M-WS. Raman scattering exhibits an anomalous nonmonotonic temperature dependence of phonon linewidths, indicative of strong phonon-electron scattering over phonon-phonon scattering.

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  • The abnormal GGGGCC hexanucleotide repeat expansions in the C9orf72 gene are linked to severe neurodegenerative diseases like ALS and frontotemporal dementia.
  • The toxic RNA forms foci that trap RNA binding proteins, disrupting RNA processing and contributing to neurodegeneration.
  • The study details the crystal structure of a specific RNA G-quadruplex, providing insight into its role in neurological toxicity and offering a basis for future therapeutic developments.
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Network pharmacology and molecular docking methods were used in the present study to clarify the molecular mechanism of two traditional Chinese medicine prescriptions of climacteric syndrome. Based on oral availability and drug similarity, the main active components of Erzhi Pill and Erxian Decoction were screened through the platform of traditional Chinese medicine system pharmacology. The target database of climacteric syndrome was established by using GENECARD, OMIM, PharmGKB, Targets and Drugbank.

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Ischemic stroke ranks among the leading causes of death and disability in humans and is accompanied by motor and cognitive impairment. However, the precise mechanisms underlying injury after stroke and effective treatment strategies require further investigation. Peroxiredoxin-1 (PRDX1) triggers an extensive inflammatory cascade that plays a pivotal role in the pathology of ischemic stroke, resulting in severe brain damage from activated microglia.

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  • The study aimed to compare the effects of sciatic nerve block combined with either continued femoral nerve block or continued adductor canal block on pain and motor function in patients after total knee arthroplasty.
  • A total of 60 patients were randomly assigned to one of two groups and various factors such as pain scores, muscle strength, and recovery times were recorded after the surgery.
  • Results indicated that while there was no significant difference in overall operation time or initial walking distance, the group receiving the adductor canal block experienced faster recovery times and better muscle strength outcomes in the early postoperative period compared to the group with the femoral nerve block.
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Tea is one of the most prevalent non-alcoholic beverages. The leaves of tea plants hyperaccumulate anthocyanins under cold stress, resulting in enhanced bitterness. Previously, we determined that the RING-type E3 ubiquitin ligase CsMIEL1 from the tea plant (Camellia sinensis (L.

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  • * Traditional aqueous MSCs have a limited operational voltage and energy density, but a new hybrid gel electrolyte using NaCl, HO, EG, and SiO has been introduced, expanding the voltage window to 1.6 V and improving performance metrics significantly.
  • * The integration of this hybrid electrolyte with 3D-printed MXene electrodes results in highly flexible MSCs with great capacitance and energy density, making them ideal for future sustainable energy storage solutions in micro-device applications.
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MnO-MnO heterostructure materials are applied in aqueous magnesium ion energy storage for the first time. The heterostructure yields an exceptionally high pseudocapacitance contribution, resulting in a specific capacitance of 313.5 F g at 1 A g, which contrasts with that of MnO (108.

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Recently, it has been reported that MXene is a promising pseudocapacitive material for energy storage, primarily due to its intercalation mechanism. However, TiCT MXenes face challenges, such as inadequate layer spacing and low specific capacity, which greatly hinder their potential as anode materials for sodium storage. In this study, MXene was doped with sulfur to create a three-dimensional porous structure that resulted in an increased layer spacing.

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  • - Aeration significantly speeds up the secondary compression of municipal solid waste (MSW) in aerobic bioreactors compared to anaerobic ones, based on tests conducted under different stress conditions.
  • - The study's results indicates that up to 100% increase in secondary compression rate can be achieved with higher aeration rates, while the steady-state strain also improves but to a lesser extent.
  • - Findings highlight that the effectiveness of aeration diminishes with increased stress levels, and specific conditions like higher moisture content and composition (e.g., paper and wood) can further enhance compression characteristics.
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Guanine (G)-rich nucleic acid sequences can form diverse G-quadruplex structures located in functionally significant genome regions, exerting regulatory control over essential biological processes, including DNA replication in vivo. During the initiation of DNA replication, Cdc6 is recruited by the origin recognition complex (ORC) to target specific chromosomal DNA sequences. This study reveals that human Cdc6 interacts with G-quadruplex structure through a distinct region within the N-terminal intrinsically disordered region (IDR), encompassing residues 7-20.

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Manganese oxides are commonly employed as a cathode for magnesium ion storage in aqueous magnesium ion hybrid supercapacitors (MHS). However, sluggish reaction kinetics still hinders their practical application. Herein, we designed K-birnessite-MnO and electrostatically spun mulberry-like carbon composites (K-MnO/HMCs) an growth technique.

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Ischemic stroke is a devastative nervous system disease associated with high mortality and morbidity rates. Unfortunately, no clinically effective neuroprotective drugs are available now. In ischemic stroke, S100 calcium-binding protein b (S100b) binds to receptor for advanced glycation end products (Rage), leading to the neurological injury.

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  • The study explores how urban block design affects microclimates in Shenyang, China, focusing on factors like street ratios and building roofs.
  • Using advanced simulation tools, researchers found that changes in street and building configurations significantly impact wind speed and temperature in cold regions.
  • Findings offer insights for designing street layouts to improve urban microclimates, taking into account human experiences and the harsh local climate.
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The splitting of water through electrocatalysis offers a sustainable method for the production of hydrogen. In alkaline electrolytes, the lack of protons forces water dissociation to occur before the hydrogen evolution reaction (HER). While pure Pt is the gold standard electrocatalyst in acidic electrolytes, since the 5d orbital in Pt is nearly fully occupied, when it overlaps with the molecular orbital of water, it generates a Pauli repulsion.

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