Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.

Type 2 diabetes increases the risk various types of cancer and is associated with a poor prognosis therein. There is also evidence that the disease is associated with cancer metastasis. Centrosome amplification can initiate tumorigenesis with metastasis and increase the invasiveness of cancer cells .

[Comparison of clinicopathological features and prognosis in familial and sporadic gastric cancer].

Objective: To analyze the clinicopathological characteristics and prognosis of familial gastric cancer and to improve the treatment outcome.

Methods: Clinical data of 67 patients with familial gastric cancer and 820 patients with sporadic gastric cancer in the Second Affiliated Hospital of Dalian Medical University from 1995 to 2005 were retrospectively analyzed.

Results: Compared to sporadic gastric cancer, the percentage of familial gastric cancer patients less than 45 years old was higher (34.