Two new chemical constituents from the aerial parts of .

has been historically employed as a conventional botanical insecticide and a plant of medicinal significance. A new dihydroagarofuran sesquiterpene () and a new acyclic compound (), along with seven known compounds (), have been isolated from the aerial parts of . The identification of the structures of novel compounds were accomplished through comprehensive spectroscopic analyses, encompassing HRESIMS, NMR, UV, IR, and a comparative analysis with spectroscopic data from compounds previously characterised.

Phenolic and flavonoid compounds from the fruit shell of .

A new phenolic compound oleiphenol (), and a new dihydrochalcone oleifechalcone () along with seven known compounds () were isolated from the fruit shell of Camellia oleifera Abel. The planar structures of compounds and were determined on the basis of extensive spectroscopic analyses (IR, UV, NMR, and HR-ESI-MS) and comparison with literature data. The absolute configurations of the new structures were determined by ECD calculations and chemical methods.

Two new pregnane glycosides from the root of .

Two new pregnane glycosides ( and ), together with four known ones (- ), were isolated from the roots of Royle ex Wight (Asclepiadaceae). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be metaplexigenin 3---D-cymaropyranosyl- (1→4)--L-diginopyranosyl-(1→4)--D-cymaropyranoside (), metaplexigenin 3---L-diginopyranosyl-(1→4)--D-cymaropyranoside (). All the isolated compounds (-) were tested for their inhibitory activity against the growth of human colon cancer cell lines HCT-116.

Two new aryltetralin-type lignans from husk.

Two new aryltetralin-type lignans () were isolated from the dichloromethane fraction of 95% ethanol extract of fruit husk. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations of compounds - were determined by the comparison of measured ECD curves with the quantum chemical calculated ones. The new compounds were tested for their antioxidant activities and cytotoxicity against three human cancer cell lines (Huh-7, H460 and MCF-7).

Two new chemical constituents from the stem and branch of .

A chemical investigation of 95% ethanol extract from the stem and branch of has resulted in the isolation and characterization of two new compounds, one neolignan () and one phenylalanine derivative (), as well as four known compounds (). The structures of the new compounds were determined based on extensive spectroscopic analyses. The absolute configuration of compound was defined by X-ray crystallographic analyses and electronic circular dichroism calculation.

Undescribed abietane-type diterpenoids and oleanane-type triterpenoids from the stem and branch of Tripterygium wilfordii.

Six undescribed abietane-type diterpenoids (tripterydinoids A-F) and five undescribed oleanane-type triterpenoids (tripterytrinoids A-E) were obtained and determined from the stem and branch of Tripterygium wilfordii Hook. f. (Celastraceae).

Diverse dihydroagarofuran sesquiterpene derivatives from the stem and branch of Tripterygium wilfordii.

Ten new dihydroagarofuran sesquiterpene polyol esters, tripterdines A-J (1-10) were isolated from the stem and branch of Tripterygium wilfordii. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including UV, IR, HRESIMS, NMR, and CD exciton chirality method. The structures of compounds 1, 3, and 6 were confirmed by X-ray crystallographic analyses.

Bixasteroid, a new compound from the fruits of and its anti-inflammatory activity.

Bixasteroid (), one new steroid together with five known compounds (-), were isolated from the ethyl acetate fraction of ethanol extract of fruits. All of these known compounds were isolated from the plant for the first time. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configuration of compound was determined by X-ray crystallographic data analysis as well as by the quantum chemical ECD calculations.

One pair of new enantiomeric trinorsesquiterpenes from the aerial parts of .

A pair of new enantiomeric trinorsesquiterpenes, (+)-genpenterpene A () and (-)-genpenterpene A (), together with seven known compounds (-), were isolated from the aerial parts of Burm.f..

New phenylpropanoids from the fruits of and their anti-inflammatory activity.

Seven new phenylpropanoids, including two pairs of enantiomers of 8--4'-type neolignans, named (±)-xanthiifructins A-B (-), a pair of simple phenylpropanoid derivatives (±)-xanthiifructins C (), and a racemic phenylpropanoid derivative xanthiifructin D (), together with four known analogues (-) were isolated from the fruits of . Racemic xanthiifructins A-C were separated on chiral HPLC columns. Their structures were elucidated by comprehensive spectroscopic data analysis and comparison with the literatures.

[Chemical constituents from Xanthii Fructus].

This study was carried out to investigate the chemical constituents from Xanthii Fructus(the fruits of Xanthium sibiricum). The compounds were separated and purified by silica gel column chromatography, Sephadex LH-20 and ODS chromatography and semi-preparative HPLC. Base on HR-ESI-MS, NMR and other spectral data, their structures were identified.

Bioactive sulfur-containing compounds from Xanthium sibiricum, including a revision of the structure of xanthiazinone.

Seven previously undescribed sulfur-containing compounds, (+)- and (-)-xanthiazinone A, (+)- and (-)-xanthiazinone B, (+)- and (-)-xanthiazinone C and xanthiazinone D, and four known thiazinedione derivatives, together with three thiophene derivatives were isolated from the fruits of Xanthium sibiricum. Racemic xanthiazinones A-C were separated by chiral HPLC columns. Their chemical structures were elucidated based on extensive spectroscopic analyses, ECD calculations, and single crystal X-ray diffractions.

Lyciiterpenoids A-D, four new rearranged eudesmane sesquiterpenoids from Lycii Cortex.

Four new rearranged eudesmane sesquiterpenoids, Lyciiterpenoids A-D (), together with four known compounds () were isolated from the aqueous extract of Lycii Cortex. Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds were determined by the quantum chemical ECD calculations. The absolute configuration of was further confirmed by X-ray crystallographic data analysis.

New compounds from the aerial parts of Burm.f. and their antioxidant and anti-inflammatory activities.

Three new compounds (-), together with six known compounds (-), were isolated from the ethyl acetate fraction of ethanol extract of the aerial parts of Burm.f. All of these known compounds were isolated from the plant for the first time.

Barbaram, a bicyclic neolactam from the root and stem of .

Barbaram (), a neolactam together with other five known compunds (-) was isolated from the EtOAc-soluble fraction of an EtOH extract of the root and stem of by using silica gel, Sephadex LH-20 column chromatography and semi-preparative RP-C HPLC. Based on HR-TOF-MS, NMR spectral data, quantum chemistry ECD calculations and referencing to the data reported earlier, the structures of these compounds (-) were determined, specially including the absolute configuration of the neolactam (). Compounds and showed significant anti-inflammatory activity in LPS-induced RAW 264.

Lyciyunin, a new dimer of feruloyltyramine and five bioactive tyramines from the root of Kuang.

Lyciyunin, a new dimer of feruloyltyramine (), together with five known tyramines (), was isolated from the water-soluble fraction of an EtOH extract of the root of . Based on HR-TOF-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was determined, including its absolute configuration. Compounds () were tested for their antioxidant activity using DPPH radical scavenging assay, and showed the moderate antioxidant activities with IC values of 12.

Anticandidal Potential of Stem Bark Extract from and the Identification of Its Major Anticandidal Compound.

Plant-derived extracts are a promising source of new drugs. is traditionally used in China for heat clearing, detoxification, and treatment of furuncles. In this study, the anticandidal properties and mechanism of action of (SSE) were explored using a stem bark extract.

Sasanquasaponin ΙΙΙ from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells.

Background: Melanoma is a high fatality skin cancer which lacks effective drugs. Sasanquasaponin, an important sort of constituents in theaceae, has been demonstrated to have potent anti-tumor effect in breast cancer and hepatocellular carcinoma. As a sasanquasaponin, we speculate that Sasanquasaponin III (SQS III) isolated from Schima crenata Korth may also have anti-tumor activity.

Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.

Background: There have been some reports implicating the pharmacologic action of Dihydrosanguinarine (DHSA), but little research including the effects of it on cancer cells. PANC-1 cells have mutations in K-Ras and TP53, which respectively express mutant K-Ras and p53 protein, and the mutations in Ras/p53 have been believed with closely relationship to the occurrence of various tumors.

Purpose: To reveal the inhibition of Dihydrosanguinarine on pancreatic cancer cells (PANC-1 and SW1990) proliferation by inducing G0/G1 and G2/M phase arrest via the downregulation of mut-p53 protein, inducing apoptosis and inhibiting invasiveness through the Ras/Mek/Erk signaling pathway.

Three new lignanamides from the root of with anti-inflammatory activity.

Three new lignanamides, that is, a new lignanamide (), and a pair of enantiomers ( and ) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root of . The structures of these new compounds, including their absolute configuration, were established on the basis of HR-ESI-MS, NMR spectroscopic data and quantum chemical ECD calculations. Compound showed significant anti-inflammatory activity in LPS-induced RAW 264.

A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity.

A new lignanamide (), lyciumamide K, together with four known analogues (-), was isolated from the root of Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds - in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities.

Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.

Anandins A () and B (), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively.

A new secondary metabolite from the fermented mycelia of Streptomyces antibiotic H41-55.

An actinomycete strain, H41-55 from sea sediment was identified as Streptomyces antibiotic on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA data. A new secondary metabolite, (2S,3R)-N-[3-(formylamino)-2-hydroxybenzoyl]-l-threonine propyl ester (1), together with five known compounds was isolated from fermentation product by use of silica gel and Sephadex LH-20 column chromatography, and preparative RP-C18 HPLC, and identified by HR-TOF-MS and NMR spectra. The cytotoxicities of these isolates against three cancer cell lines and their antifungal activities on Candida albicans were tested.

Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09.

An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR.