Konjac glucomannan/ carboxylated cellulose nanofiber-based edible coating with tannic acid maintains quality and prolongs shelf-life of mango fruit.

Polysaccharide films containing antimicrobial agents have good prospects for application in the fruit industry. However, poor film-forming properties of polysaccharides remain a major challenge. In this work, the konjac glucomannan (KGM) was modified by cross-linking with carboxylated cellulose nanofibers (CNF) to form a composite coating film, and tannic acid (TA) was provided as an active ingredient to improve the antibacterial effect.

Unknown weak light pulse measurement using time interval distribution photon counting.

In this paper, we present a method for measuring weak light pulses using a single-photon detector, with a focus on detecting non-synchronized repetitive pulsed light. The proposed approach, based on interval distribution counting, enables accurate reconstruction of both the repetition rate and phase of weak pulses, facilitating the determination of the average photon number and pulse width. Specifically, the error in reconstructing the repetition rate is below ±0.

Synthesis of [NiSeX(PEt)] (X = Br, I) via Post-synthetic Modification.

Treatment of [NiSeCl(PEt)] () with excess MeSiX (X = Br, I) results in formation of [NiSeX(PEt)] (X = Br, ; X = I, ) in good yields. and are exceptionally rare examples of atomically precise nickel nanoclusters (APNCs). Both and were characterized by X-ray crystallography, NMR spectroscopy, and ESI-mass spectrometry.

Targeting estrogen-regulated system x promotes ferroptosis and endocrine sensitivity of ER+ breast cancer.

Estrogen receptor positive (ER+) breast cancer accounts for approximately 70% of cases. Endocrine therapies targeting estrogen are the first line therapies for ER+ breast cancer. However, resistance to these therapies occurs in about half of patients, leading to decreased survival rates.

Preparation and evaluation of ozone micro-nano bubbles ice for Litchi precooling.

Ozone (O) is an effective agent for post-harvest fruit preservation against diverse microorganisms. In this study, a cost-effective ozone micro-nano bubbles ice (O-MNBI) was prepared, characterized, and subsequently used to precool litchi. The optimal protocols for O-MNBI production were as follows: water (2 °C, pH = 7) was pumped into a micro-nano O bubble generator for 10 min aeration treatment.

USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis.

Anti-estrogen endocrine therapies greatly improve survival of estrogen receptor positive (ER + ) breast cancer. Unfortunately, about 30% of patients do not respond to endocrine therapies initially. We previously showed that deubiquitinase USP35 and ERα act in a positive feedback loop to promote the carcinogenesis of ER+ breast cancer although it is unclear whether USP35 regulates cell death in ER+ breast cancer.

Development and Assessment of a Color-Variable Chlorine Dioxide Slow-Releasing Card for Litchi Preservation.

Chlorine dioxide (ClO) gas has attracted considerable attention due to its safety and efficiency. In this study, we successfully developed a color-variable ClO slow-releasing card for postharvest litchi. The optimal ClO slow-releasing card was prepared as follows: Card A was soaked in 2.

Fixation of Expression Divergences by Natural Selection in Coding Genes.

Functional divergences of coding genes can be caused by divergences in their coding sequences and expression. However, whether and how expression divergences and coding sequence divergences coevolve is not clear. Gene expression divergences in differentiated cells and tissues recapitulate developmental models within a species, while gene expression divergences between analogous cells and tissues resemble traditional phylogenies in different species, suggesting that gene expression divergences are molecular traits that can be used for evolutionary studies.

Targeting autophagy: polydatin's role in inducing cell death in AML.

Acute myeloid leukemia (AML), a malignant disorder of the hematopoietic system, arises from leukemic stem cells (LSCs) and is the most prevalent form of blood cancer in adults. This study aimed to evaluate the therapeutic potential of polydatin (PD) in AML through and studies, respectively. This study was prompted by PD's novel role in enhancing tumor apoptosis and modulating autophagy.

Tenecteplase thrombolytic therapy for acute ischaemic stroke in China: a real-world, multicentre, retrospective, controlled study.

Background And Aims: Tenecteplase (TNK) offers logistical advantages in stroke thrombolytic therapy with its single bolus administration compared with alteplase. We aim to investigate the real-world evidence regarding its safety and effectiveness in China.

Methods: We conducted a retrospective study on patients receiving alteplase or TNK for acute ischaemic stroke (AIS) within 4.

Iodide Double Perovskites and the Limits of their Structural Stability.

While halide double perovskites AM(I)M(III)X have attracted significant attention, examples involving iodides are rare. We examine the limits of the structural stability of iodide double perovskites, presenting the synthesis and single-crystal structures of CsNaScI and CsNaYI. Bypassing the common expectation that iodides have small band gaps, these compounds display optical gaps of 3.

An Actinide Complex with a Nucleophilic Allenylidene Ligand.

The reaction of [CpTh(3,3-diphenylcyclopropenyl)] (Cp = η-CH) with 1 equiv of lithium diisopropylamide (LDA) results in cyclopropenyl ring opening and formation of the thorium allenylidene complex, [Li(EtO)][CpTh(CCCPh)] ([Li(EtO)][]), in good yield. Additionally, deprotonation of [CpTh(3,3-diphenylcyclopropenyl)] with 1 equiv of LDA, in the presence of 12-crown-4 or 2.2.

A homoleptic Fe(iv) ketimide complex with a low-lying excited state.

The reaction of 4 equiv. of Li(N[double bond, length as m-dash]C( Bu)Ph) with FeCl results in isolation of [Li(EtO)][Fe(N[double bond, length as m-dash]C( Bu)Ph)] (1), in good yields. The reaction of 1 with 1 equiv.

Evolution, classification, structure, and functional diversification of steroid 5α-reductase family in eukaryotes.

Steroid 5α-reductase1/2 (SRD5A1/2) is an androgen protein that resembles the plant DET2 and is responsible for the conversion of testosterone to the more active dihydrotestosterone (DHT). Both proteins share functional homology and have a common ancestor. In mammals, the SRD5A1/2 can reduce a wide range of steroid substrates, such as testosterone, progesterone, and aldosterone, by reducing the Δ in ring A.

Associations of Blood Cadmium Levels With Osteoarthritis Among US Adults in NHANES 2013-2018.

Background: Osteoarthritis (OA) is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA.

Method: Weighted multivariable logistic regression model, trend test, restricted cubic spline, and stratified analysis were used to study the association between BCd and OA.

Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial.

Background: Hyperlipidemia is a common feature of chronic diseases. The aim of this work was designed to assess the role of probiotics (Lactobacillus casei Zhang, Bifidobactetium animalis subsp. lactis V9, and Lactobacillus plantarum P-8) in the treatment of hyperlipidemia.

Bona Fide Plant Steroid Receptors are Innovated in Seed Plants and Angiosperms through Successive Whole-Genome Duplication Events.

Whole-genome duplication (WGD) events are widespread in plants and animals, thus their long-term evolutionary contribution has long been speculated, yet a specific contribution is difficult to verify. Here, we show that ɛ-WGD and ζ-WGD contribute to the origin and evolution of bona fide brassinosteroid (BR) signaling through the innovation of active BR biosynthetic enzymes and active BR receptors from their respective ancestors. We found that BR receptors BRI1 (BR INSENSITIVE 1) and BRL1/3 (BRI1-LIKES 1/3) derived by ɛ-WGD and ζ-WGD, which occurred in the common ancestor of angiosperms and seed plants, respectively, while orphan BR receptor BRL2 first appeared in stomatophytes.

Clarification of the infection pattern of Xanthomonas citri subsp. citri on citrus fruit by artificial inoculation.

Background: Citrus canker is a significant bacterial disease caused by Xanthomonas citri subsp. citri (Xcc) that severely impedes the healthy development of the citrus industry. Especially when citrus fruit is infected by Xcc, it will reduce or even lost its commercial value.

KCTD5 regulates Ikaros degradation induced by chemotherapeutic drug etoposide in hematological cells.

Therapy-related leukemia carries a poor prognosis, and leukemia after chemotherapy is a growing risk in clinic, whose mechanism is still not well understood. Ikaros transcription factor is an important regulator in hematopoietic cells development and differentiation. In the absence of Ikaros, lymphoid cell differentiation is blocked at an extremely early stage, and myeloid cell differentiation is also significantly affected.

Exploring Spin-Orbit Effects in a [CuTl] Nanocluster Featuring an Uncommon Tl-H Interaction.

Reaction of [CuH(PPh)] with 1 equiv. of Tl(OTf) results in formation of [CuTlH(PPh)][OTf] ([1]OTf]), which can be isolated in good yields. Variable-temperature H NMR spectroscopy, in combination with density functional theory (DFT) calculations, confirms the presence of a rare Tl-H orbital interaction.

An update on evolutionary, structural, and functional studies of receptor-like kinases in plants.

All living organisms must develop mechanisms to cope with and adapt to new environments. The transition of plants from aquatic to terrestrial environment provided new opportunities for them to exploit additional resources but made them vulnerable to harsh and ever-changing conditions. As such, the transmembrane receptor-like kinases (RLKs) have been extensively duplicated and expanded in land plants, increasing the number of RLKs in the advanced angiosperms, thus becoming one of the largest protein families in eukaryotes.

pH regulators and their inhibitors in tumor microenvironment.

As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely related to immune escape, invasion, migration and drug resistance of tumor. The acidity of the TME mainly comes from the acidic products produced by the high level of tumor metabolism, such as lactic acid and carbon dioxide. pH regulators such as monocarboxylate transporters (MCTs), carbonic anhydrase IX (CA IX), and Na/H exchange 1 (NHE1) expel protons directly or indirectly from the tumor to maintain the pH balance of tumor cells and create an acidic TME.

Microbial contribution to 14 biogenic amines accumulation in refrigerated raw and deep-fried hairtails (Trichiurus lepturus).

Biogenic amines (BAs) produced by microbial decarboxylation of amino acids are crucial toxic nitrogenous compounds in fish. An optimized ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method with simple pretreatment was established to detect 14 BAs in both raw (control check, CK) and deep-fried (DF) hairtails. This method exhibited a good linear relationship with average recoveries of 73.