Publications by authors named "Guang Ming Lu"

Purpose: To compare virtual non-enhanced liver CT (VNCT) from dual-energy CT (DECT) with true non-enhanced liver CT (TNCT) in patients.

Methods: A total of 102 patients underwent multi-phase abdominal CT. Liver arterial VNCT (VNCT(A)) and portovenous VNCT (VNCT(V)) images were derived from the arterial and portovenous DECT data.

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Background And Purpose: Wallerian degeneration (WD), the secondary degeneration of axons from cortical and subcortical injuries, is associated with poor neurological outcome. There is some quantitative MR imaging techniques used to estimate the biologic changes secondary to delayed neuronal and axonal losses. Our purpose is to assess the sensitivity of ADC value and T(2) relaxation time for early detection of WD.

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Objective: The purpose of this study was to evaluate the image quality, radiation dose, and diagnostic accuracy of dual-energy CT angiography (CTA) compared with 3D rotational digital subtraction angiography (DSA) in the detection of intracranial aneurysms.

Subjects And Methods: Forty-six patients with clinically suspected intracranial aneurysms underwent dual-source dual-energy CTA and 3D DSA. For the analysis of the image quality and radiation dose of dual-energy CTA, 46 patients who underwent digital subtraction CTA were recruited as a control group.

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Aim: To prepare anti-Sperm protein 17 (Sp17) immunomagnetic nanoparticles (IMNPs), and make foundation for target diagnosis of ovarian cancer by magnetic resonance imaging.

Methods: The anti-human Sp17 IMNPs were prepared by grafting anti-Sp17 antibodies on the surface of chitosan-coated magnetic nanoparticles (MNPs) using the linker of EDC/NHS (1-ethyl-3-[3-dimethylaminopropyl]carbodiimide/N-hydroxysuccinimide). The morphology and properties of the nanoparticles were characterized by transmission electronic microscopy (TEM), the conjugation of the antibodies was evaluated by native-polyacrylamide gel electrophoresis, the immunologic activity of IMNPs was evaluated by enzyme linked immunosorbent assay (ELISA).

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The purpose of the study was to compare the ability of dual energy CT (DECT) and perfusion scintigraphy (PS) to detect pulmonary embolism (PE) in a rabbit model. Gelfoam (n = 20) or saline (n = 4) was injected into the femoral vein of rabbits. After 2 h, DECT pulmonary angiography (CTPA) was used to create blood flow imaging (BFI) and fusion images.

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Background: Detection of a suspected pulmonary embolism (PE) has been the focus of considerable research over the past few decades. Recently developed dual-source computed tomography (DSCT) scanners with dual-energy mode have been used to detect PE, but the studies on this topic are few.

Purpose: To assess the clinical value of dual-source, dual-energy CT (DECT) for the diagnosis of suspected PE and to correlate with cardiovascular measurements.

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Background: Myocardial bridging (MB), also known as a tunneled artery, is a congenital anomaly that can be readily diagnosed with multidetector-row computed tomography (MDCT). With the advent of dual-source CT (DSCT), it may be feasible to evaluate dynamic changes of MB throughout the entire cardiac cycle.

Purpose: To determine the feasibility of dynamic evaluation of MB using DSCT.

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Purpose: To evaluate feasibility and added value of dual-energy computed tomography (CT) in diagnosis of pulmonary embolism (PE).

Materials And Methods: This institutional animal experimental committee-approved study was performed in accordance with animal care guidelines. Eight New Zealand rabbits underwent standard unenhanced and contrast material-enhanced dual-source CT.

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Purpose: The purpose of this study was to assess the clinical value of dual-source computed tomography (DSCT) in the detection and dynamic evaluation of the anomalous origin of the right coronary artery originating from the left coronary sinus of Valsalva (ARCAOLS) with an interarterial course.

Materials And Methods: Thirteen patients with ARCAOLS with an interarterial course and 11 controls with normal origin of the right coronary artery (RCA) were included into this study from December 2006 to April 2008. The origin and course of the RCA were determined on maximum intensity projection, volume rendering, and virtual endoscopy images.

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Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, which rarely occurs in bone. We present a case of ASPS in a 23-year-old man with a 2-month history of back pain. Computed tomography scanning and magnetic resonance images demonstrated a destructive process in the 12th thoracic vertebra associated with a unilateral soft tissue mass.

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Objective: To explore the role of TBX3 gene in the pathogenesis of breast cancer.

Methods: The total RNA of 51 fresh breast cancer tissues and the corresponding adjacent tissues were extracted and reverse transcribed into cDNA to detect the expression of TBX3 mRNA by real-time PCR. The correlation between TBX3 mRNA expression and the clinicopathologic parameters in relation to breast cancer metastasis was analyzed.

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Article Synopsis
  • The study aimed to analyze changes in the amplitude of low-frequency fluctuations (ALFF) in resting-state functional MRI scans of patients with mesial temporal lobe epilepsy (mTLE) and bilateral hippocampal sclerosis (HS).
  • Researchers compared ALFF data from 20 mTLE patients to that of 20 healthy volunteers, identifying regions of the brain with increased and decreased ALFF using statistical analysis.
  • Results showed that mTLE patients displayed symmetrical increases in ALFF in areas related to limbic function and neocortex, while decreases were found in regions associated with the default mode network, suggesting that altered brain activity may influence the generation and spread of epileptic seizures.
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Article Synopsis
  • The study aimed to develop a technique for identifying areas in the brain that can cause epilepsy using fMRI, without needing to record brain waves through EEG.
  • Researchers analyzed resting fMRI data from 12 epilepsy patients using independent component analysis and functional connectivity analysis to identify brain activity changes.
  • Results showed that the new method accurately located pathological brain areas in all patients, confirming its effectiveness in mapping brain functions associated with epilepsy without needing simultaneous EEG recordings.
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Objective: To assess the ability to detect myocardial bridging (MB) of dual-source computed tomography (DSCT) compared with conventional coronary angiography (CAG).

Methods: Both DSCT coronary angiography (DSCTCA) and CAG were performed on 53 patients diagnosed or suspected as with coronary artery disease (CAD), 45 males and 8 females, aged 36-87. 4D cine mode was performed on 16 of these 53 patients with MB shown on DSCTCA, and the CAG data were reviewed retrospectively by automatic cine method.

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Background: Few investigators have studied the anatomy of the sinus node artery (SNA) using noninvasive imaging modalities, so the objective of this study was to visualize the in-vivo 3-dimensional anatomical relations of the SNA using dual-source computed tomography (DSCT).

Methods And Results: In the 101 patients included in this study, the visualization rate, anatomical type and diameter of the SNA, the distance between the orifice and coronary artery, and the terminal type of SNA were recorded. The visualization rate was 95.

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Background: The diagnosis of myocardial bridging (MB) is of clinical importance because of the association between MB and compromised coronary flow. The aim of this study was to compare the ability of dual-source computed tomography (DSCT) and conventional coronary angiography (CAG) to detect MB.

Methods And Results: DSCT were performed in 53 patients and 4-dimensional (D) reconstruction was subsequently performed in 16 patients with MB for double-blinded comparison with the findings of CAG.

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Objective: EphB1 is a member of the Eph family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. Over- or underexpression of certain Eph receptors has been found in some cancer samples compared to normal tissue. Expression of Eph receptors is related to malignant transformation, metastasis, differentiation, and prognosis of cancers.

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Bronchial artery aneurysm is a rare entity, detected in less than 1% of all patients undergoing selective bronchial arteriograms. Approximately 50 cases have been reported so far. Computed tomography (CT) reports of mediastinal bronchial artery aneurysms are rare.

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Objective: To compare the CT enhancement degree in pancreatic carcinoma (PC) and inflammatory pancreatic mass (IPM), and to study the diagnostic value of CT to these two diseases.

Methods: Eighty-five patients with PC or IPM, 47 males and 38 females, aged 62 (37-79), underwent plain CT scanning and enhanced CT scanning in pancreatic phase and delay phase. The CT values of the pancreatic mass and relative normal pancreatic tissue were measured.

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Objective: To discuss the computer tomography(CT) appearances of the enterocutaneous fistula classification.

Methods: CT scan was performed on 754 patients with enterocutaneous fistula, which were divided into tube fistula and labiate fistula according to clinic classification, and the appearances of CT scan were analyzed respectively.

Results: Five hundreds and eighteen patients (68.

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Objective: To explore the effects of zinc supplementation on zinc and calcium levels in serum and tissue in burned rats.

Methods: Eighty SD rats were randomly divided into C group (control group without scald, n = 8), and N, W, H groups (each consisting of 24 rats), in which the rats were exposed to scalding resulting in partial thickness burns covering 15% of the total body surface area on the back, and then they were fed with diets containing zinc 40 microg/g in N and W groups, and 80 microg/g in H group. A cream containing zinc 761.

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Objective: To explore the value of dynamic enhanced magnetic resonance (MR) in diagnosis of pancreatic carcinoma and endocrine tumors.

Methods: Twenty-two patients with pancreatic carcinoma and 9 patients with pancreatic endocrine tumors underwent routine MR scanning and dynamic contrast enhanced MR examination before they underwent operation.

Results: No tumor image was seen in 4 of the 22 patients with pancreatic carcinoma by routine MR scanning.

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Objective: The purpose of this work was to study the correlation of pancreatic phase CT enhancement, intratumoral microvessel density (MVD) and histopathological grades in pancreatic carcinoma and to evaluate the relationship between CT enhancement degree and the malignancy degree of pancreatic carcinoma.

Methods: 34 patients with pancreatic carcinoma underwent CT scanning before resection. The enhancement degrees and forms of tumor were observed in pancreatic-phase.

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