IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation.

IRF2BP2 is a transcriptional coregulator that plays diverse regulatory roles in various cellular processes in either IRF2-dependent or IRF2-independent manner through interactions with protein partners via its RING domain; however, the underlying molecular mechanisms remain unclear. In this study, we conduct a motif discovery search on the sequences of interacting proteins IRF2 and VGLL4 of IRF2BP2 and identify a conserved RxSVI motif. Biochemical and structural data reveal that the RING domain binds to the motif-containing peptides of IRF2 and VGLL4 with comparable affinities and in a similar manner.

Tunable lattice-induced transparent metasurface for dynamic terahertz wave modulation.

Tunable metasurfaces offer a promising avenue for dynamically modulating terahertz waves. Phase-change materials are crucial in this dynamic modulation, enabling precise and reversible control over the electromagnetic properties of the metasurfaces. In this study, we designed and experimentally fabricated a tunable lattice-induced transparent metasurface.

Multifaceted control of focal points along an arbitrary 3D curved trajectory.

Metalenses can integrate the functionalities of multiple optical components thanks to the unprecedented capability of optical metasurfaces in light control. With the rapid development of optical metasurfaces, metalenses continue to evolve. Polarization and color play a very important role in understanding optics and serve as valuable tools for gaining insights into our world.

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes.

Biochemical and structural characterization of the DNA-binding properties of human TRIP4 ASCH domain reveals insights into its functional role.

TRIP4 is a conserved transcriptional coactivator that is involved in the regulation of the expression of multiple genes. It consists of a classical N-terminal C2HC5-like zinc-finger domain and a conserved C-terminal ASCH domain. Here, we characterized the DNA-binding properties of the human TRIP4 ASCH domain.

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways.

High-Temperature Protonic Conduction in LaNiO -Based Ruddlesden-Popper Type Oxides: Correlation with Concentration of Interstitial Oxide Ions.

Oxygen-excess LaNiO (LNO) conducts oxide ions, electron holes, and hydroxide ions simultaneously on exposing to wet oxygen, exhibiting the potential as a cathode material in protonic ceramic fuel cells. Since the incorporation of protons in oxygen-excess LNO is via the hydration reaction assisted by interstitial oxide ions, in this work, the concentration of interstitial oxide ions is reduced and increased by substituting Ni with Cu and Co, respectively. A higher concentration of interstitial oxide ions leads to a high proton concentration, indicating the predominant role of interstitial oxide ions in the hydration reaction, different from that in the oxygen-deficient oxides, where protons are introduced by dissociative absorption of water molecules by oxygen vacancies.

Frequency suppression of director oscillations in AC-driven liquid-crystal-based terahertz phase shifters.

Frequency-induced instability is widely present in nematic liquid crystals (LCs), which poses a problem in improving liquid-crystal-based phase-shift devices driven by alternating currents. Herein, the Fréedericksz transition of thick nematic LCs was investigated under alternating electric fields to reveal the suppression of frequency-induced instability in the low frequency range. By extending the Frank-Leslie equation to the AC-driven case, the response of the LC was numerically calculated, and the frequency threshold for suppressing the driven instability was estimated in conjunction with the perturbation method.

Longitudinally variable 3D optical polarization structures.

Generation and manipulation of three-dimensional (3D) optical polarization structures have received considerable interest because of their distinctive optical features and potential applications. However, the realization of multiple 3D polarization structures in a queue along the light propagation direction has not yet been reported. We propose and experimentally demonstrate a metalens to create longitudinally variable 3D polarization knots.

Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk.

Importance: Clinical trial data have called into question the efficacy of thiazide diuretics for the prevention of kidney stones.

Objective: To identify whether there is an association between genetic proxies of thiazide diuretics and the risk of kidney stones.

Design, Setting, And Participants: This genetic association study undertook a mendelian randomization analysis of derived exposures and outcomes from genome-wide association study summary statistics.

Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.

Interferon regulatory factor 4 (IRF4) is a transcription factor that regulates the development and function of immune cells. Recently, a new multimorphic mutation T95R was identified in the IRF4 DNA-binding domain (DBD) in patients with autosomal dominant combined immune deficiency. Here, we characterized the interactions of the wild-type IRF4-DBD (IRF4-DBD) and T95R mutant (IRF4-DBD) with a canonical DNA sequence and several noncanonical DNA sequences.

Multifunctional transmission polarization conversion metasurface based on dislocation-induced anisotropy at the terahertz frequency.

Manipulating the polarization state of terahertz waves is critical for terahertz communication systems. This study proposes a terahertz band polarization conversion metasurface based on dislocation-induced anisotropy. Numerical simulation results revealed that the polarization conversion of orthogonal linearly polarized light, orthogonal circularly polarized light, linearly polarized light to circularly polarized light, and circularly polarized light to linearly polarized light can be realized.

Partial Sulphidation to Regulate Coordination Structure of Single Nickel Atoms on Graphitic Carbon Nitride for Efficient Solar H Evolution.

To develop a non-precious highly efficient cocatalyst to replace Pt on graphitic carbon nitride (g-C N ) for solar H production is great significant, but still remains a huge challenge. The emerging single-atom catalyst presents a promising strategy for developing highly efficient non-precious cocatalyst owing to its unique adjustability of local coordination environment and electronic structure. Herein, this work presents a facile approach to achieve single Ni sites (Ni -N S) with unique local coordination structure featuring one Ni atom coordinated with two nitrogen atoms and one sulfur atom, confirmed by high-angle annular dark-field scanning transmission electron microscopy, X-ray absorption spectroscopy, and density functional theory calculation.

ognitive utcomes in the ragmatic nvestigation of optimaxygen argets (CO-PILOT) trial: protocol and statistical analysis plan.

Introduction: Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive mechanical ventilation. Recommended oxygen targets during mechanical ventilation vary among international guidelines. Different oxygen targets during mechanical ventilation have the potential to alter long-term cognitive function due to cerebral hypoxemia or hyperoxemia.

Molecular mechanism of -adenosylmethionine sensing by SAMTOR in mTORC1 signaling.

The mechanistic target of rapamycin-mLST8-raptor complex (mTORC1) functions as a central regulator of cell growth and metabolism in response to changes in nutrient signals such as amino acids. SAMTOR is an -adenosylmethionine (SAM) sensor, which regulates the mTORC1 activity through its interaction with the GTPase-activating protein activity toward Rags-1 (GATOR1)-KPTN, ITFG2, C12orf66 and SZT2-containing regulator (KICSTOR) complex. In this work, we report the crystal structures of SAMTOR in apo form and in complex with SAM.

Electronically controlled flexible terahertz metasurface based on the loss modulation of strontium titanate.

A flexible terahertz metamaterial is designed to control the transmittance through an external electric field. Two different metallic structures, the split ring (type I structure) and the split ring inside a ring (type II structure), were prepared and voltage was applied through a forked finger electrode. The structures were wrapped in a thin film made by mixing strontium titanate nanopowder with polyimide in a certain ratio.

Coaxial double-hole PEDOT: PSS electrodes achieving tunable terahertz zoomable convergence.

The local wavefront modulation technique in the terahertz band is an important basis for the development of terahertz modulation technology. Here, an electrically controlled convergent tunable device based on patterned transparent electrode poly (3, 4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS) is realized to locally tune the terahertz wavefront. The device consists of two substrates with circular-hole electrodes and liquid crystal sandwiched between them.

The Effect of Hyperbaric Oxygen on Bone Healing Efficiency After Maxillary Sinus Lateral Augmentation Using Xenograft: An In Vivo Pilot Study on Histomorphometric Analysis.

It was hypothesized that hyperbaric oxygen (HBO) could increase bone healing efficiency according to a protocol with a special window of healing time when maxillary sinus lateral augmentation is performed with only xenograft. The histomorphometric efficiency of HBO on the maxillary sinus lateral augmentation was examined by designing five different in vivo healing periods. Five patients receiving maxillary sinus lateral augmentation with xenograft each received a different treatment healing protocol: 6 weeks natural healing (control [Ctl]), 5 weeks with HBO (T1), 6 weeks with HBO (T2), 9 weeks with HBO (T3), and 13 months natural healing (TM).

Active polarization-independent plasmon-induced transparency metasurface with suppressed magnetic attenuation.

A tunable polarization-independent plasmon-induced transparency (PIT) metasurface based on connected half-ring and split-ring resonators is proposed to working in the terahertz band. We analyze the PIT effect in metasurfaces comprising of ring resonator and split ring resonator. Due to the magnetic attenuation caused by the reverse current between the two resonators, the relative position of the ring resonator and the split-ring resonator greatly affects the strength of the PIT effect.

Efficient terahertz polarization conversion with hybrid coupling of chiral metamaterial.

We propose an ultrathin terahertz waveplate of bi-layer chiral metamaterial for cross-polarization conversion at asymmetric transmission. The chiral metamaterial is constructed with hybrid coupling plasmonic resonators of a concentric ring and a double-split ring. The terahertz metamaterial can efficiently convert the ${y}$y-polarized wave into the ${x}$x-polarized wave with the cross-polarized transmittance over 97% and the polarization conversion ratio of 99% in simulation.

Inhibition of Autophagy via Lysosomal Impairment Enhances Cytotoxicity of Fullerenol under Starvation Condition.

Autophagy is well-known as a common cellular response to nanomaterials. As one of the most comprehensively studied carbon-based nanomaterials, fullerene and its derivatives have been reported to bring about autophagic features in various cell lines, but little is known about the role of fullerenol (C(OH)) on the modulation of autophagy in human gastric tumor cell line SGC-7901. Fullerenol treatment led to the accumulation of autophagosomes, as evidenced by the increased fluorescent intensity of monodansylcadaverine (MDC) staining cells, an elevated level of LC3 protein, and the observation of auotphagosomes in cytoplasm.

A LiAlO/nitrogen-doped hollow carbon spheres (NdHCSs) modified separator for advanced lithium-sulfur batteries.

Lithium-sulfur (Li-S) batteries have gained significant attention due to their ultrahigh theoretical specific capacity and energy density. However, their practical commercialization is still facing many intractable problems, of which the most difficult is the shuttle effect of dissolved polysulfides. To restrict the shuttle of polysulfides, herein, a novel double-layer lithium aluminate/nitrogen-doped hollow carbon sphere (LiAlO/NdHCSs)-modified separator was designed.

Characterization of fullerenol-protein interactions and an extended investigation on cytotoxicity.

Fullerenols, known as polyhydroxylated derivatives of fullerene, have attracted great attention due to their distinctive material properties and potential applications in biology and medicine. As a step toward the elucidation of basic behavior in biological systems, a variety of spectroscopic measurements as well as isothermal titration calorimetry (ITC) were applied to study the interaction between fullerenol (C(OH)) and serum proteins (bovine serum albumin (BSA) and γ-globulins). The results of fluorescence spectra indicated that the intrinsic fluorescence of proteins could be effectively quenched by the dynamic mechanism.