Publications by authors named "Guan-Wang Shen"
Estrogen-related receptor, a molecular target against lepidoptera pests.
Pestic Biochem Physiol
June 2024
Article Synopsis
- - The study focuses on estrogen-related receptors (ERRs) in silkworms (Bombyx mori), which are sensitive to pesticides and serve as models for evaluating insecticides.
- - Researchers identified ERR expression in silkworm organs that metabolize pesticides and found many ERR target genes using ChIP-seq technology.
- - The study suggests that small molecule inhibitors of ERR could be effective in controlling Lepidoptera pests due to their significant impact on pest metabolism and development.
Introduction: Signal peptide peptidase () is an intramembrane protease involved in a variety of biological processes, it participates in the processing of signal peptides after the release of the nascent protein to regulate the endoplasmic reticulum associated degradation (ERAD) pathway, binds misfolded membrane proteins, and aids in their clearance process. Additionally, it regulates normal immune surveillance and assists in the processing of viral proteins. Although is essential for many viral infections, its role in silkworms remains unclear.
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