Publications by authors named "Guan-Ji Wu"
Article Synopsis
- Vascular aging, which relates to arterial health and is a key indicator of heart disease risk, was studied in relation to long-term blood pressure variability (BPV) from childhood to midlife in a cohort of 2065 participants.
- The study found that greater fluctuations in both systolic and diastolic blood pressure over 30 years correlated significantly with increased arterial stiffness, carotid hypertrophy, and carotid plaque development during midlife.
- These findings suggest that monitoring long-term blood pressure variability from an early age could be vital for predicting cardiovascular diseases later in life, regardless of average blood pressure levels.
The E-proteinoid 3 receptor (PTGER3), a member of the prostaglandin E2 (PGE2) subtype receptor, belongs to the G-protein-coupled superfamily of receptors. Animal studies have demonstrated its involvement in salt sensitivity by regulating sodium reabsorption. This study aimed to investigate the association between genetic variants of PTGER3 and salt sensitivity, longitudinal blood pressure (BP) changes, and the incidence of hypertension in Chinese adults.
View Article and Find Full Text PDFBackground And Aims: Obesity is an independent risk factor for cardiovascular disease development. Here, we aimed to examine and compare the predictive values of three novel obesity indices, lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose (TyG) index, for cardiovascular subclinical organ damage.
Methods: A total of 1,773 healthy individuals from the Hanzhong Adolescent Hypertension Study cohort were enrolled.
Article Synopsis
- SGLT2 inhibitors can lower blood pressure and affect how the body responds to salt, making them relevant in studying salt sensitivity.
- A research study, involving 514 participants over 14 years, explored the relationship between specific SGLT2 genetic variants and changes in blood pressure, especially under different salt diets.
- Notable findings included that certain SGLT2 SNPs (like rs3813007) were linked to lower blood pressure on a low-salt diet and others (rs3116149, rs3813008) were tied to overall blood pressure changes and risk of developing hypertension.
Background: Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. We aimed to explore the associations of individual cardiovascular risk factors from childhood to midlife and their accumulation over a 30-year span with vascular aging in midlife.
Methods: Using data from the ongoing cohort of Hanzhong Adolescent Hypertension study, 2180 participants aged 6 to 18 years at baseline were followed for over 30 years.
Atherosclerosis (As) is a common disease, which is serious hazard to human health. As the main pathological basis of ischemic cardiac and cerebral vascular disease, including coronary heart disease, cerebrovascular disease, and thromboembolic disease, it is a chronic inflammatory lesion of the arterial vessel wall. So far the pathogenesis of As has not been fully understood.
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