Publications by authors named "Guan-Chun Wu"
Article Synopsis
- Cancer cells have a high demand for sugars, and researchers developed glycopolymer-like nanoparticles that target specific receptors on cancer-associated macrophages to enhance their effectiveness in fighting tumors.
- These nanoparticles, created through a carbonization process, can alter immune cell polarization and cellular metabolism, promoting a transition from M2 (immunosuppressive) to M1 (pro-inflammatory) macrophages, which helps overcome tumor defenses.
- In models of glioblastoma and pancreatic cancer, these nanoparticles not only induced cancer cell death but also improved the effectiveness of immunotherapy by remodeling the tumor microenvironment, activating immune responses, and facilitating the activity of cytotoxic T lymphocytes and dendritic cells.
