The Seizure Detection Based on a Novel Electroencephalogram Segmentation.

Due to the non-stationary nature of electroencephalogram (EEG) signals, it is imperative to partition the EEG into quasi-stationary intervals with similar statistical characteristics. This study introduces an innovative method leveraging the relative stability of synchronous brain electrical activity for the automatic segmentation of EEG signals, eliminating the need for human intervention. The experiments illustrate that EEG signals segmented using this method demonstrate a certain level of stability across different frequency ranges and frequency power distribution.

Simultaneous functional disruption of the iron acquisition system and type VI secretion system results in complete suppression of virulence in Acinetobacter baumannii.

Acinetobacter baumannii (Ab) is one of the most significant bacterial pathogens inducing hospital-acquired infections worldwide, with a high mortality rate. The continuous emergence of multidrug-resistant (MDR) phenotypes presents a significant challenge in combating Ab infections with antimicrobial drugs. In this study, we found that the type VI secretion system and the iron transportation system synergistically enhance siderophore production and further contribute to the virulence of Ab.

Capsular polysaccharide enables to evade phagocytosis by blocking host-bacteria interactions.

Unlabelled: Capsule polysaccharide (CPS) is among the most important virulence factors of . Previous studies demonstrated that CPS plays multiple functional roles, but the mechanism by which this virulence factor enhances the survival fitness of remains unclear. In this work, we demonstrate that CPS is the main cellular component that not only elicits the host immune response to but also enables this pathogen to survive for a prolonged period under adverse environmental conditions.

Utilization of DNA Replication factor MCM2 by Cancer.

MCM2 belongs to the microchromosome maintenance [MCM] family and plays an essential role in initiating DNA replication as well as maintaining normal cellular cycle functions. Recent research indicates that there is the abnormal expression of MCM2 in various cancers, such as breast, cervical, ovarian, lung, hepatocellular carcinoma, nephroblastoma, prostate, and pancreatic cancers, where it shows a strong link to tumorigenesis, growth, invasion, migration, and adverse prognosis. Thus, MCM2 could serve as a significant biomarker for the early identification, diagnosis, and prognostic evaluation of multiple cancers.

Development and validation of a diagnostic model for migraine without aura in inpatients.

Objectives: This study aimed to develop and validate a robust predictive model for accurately identifying migraine without aura (MWoA) individuals from migraine patients.

Methods: We recruited 637 migraine patients, randomizing them into training and validation cohorts. Participant's medical data were collected such as demographic data (age, gender, self-reported headache characteristics) and clinical details including symptoms, triggers, and comorbidities.

Aspartate Metabolism-Driven Gut Microbiota Dynamics and RIP-Dependent Mitochondrial Function Counteract Oxidative Stress.

Aspartate (Asp) metabolism-mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain elusive. This study reports that chronic oxidative stress disrupts gut microbiota and metabolite balance and that such imbalance is intricately tied to the perturbation of Asp metabolism. Under normal conditions, in vivo and in vitro studies reveal that exogenous Asp improves intestinal health by regulating epithelial cell proliferation, nutrient uptake, and apoptosis.

Neuroimaging features for cognitive fatigue and its recovery with VR intervention: An EEG microstates analysis.

Introduction: Cognitive fatigue is mainly caused by enduring mental stress or monotonous work, impairing cognitive and physical performance. Natural scene exposure is a promising intervention for relieving cognitive fatigue, but the efficacy of virtual reality (VR) simulated natural scene exposure is unclear. We aimed to investigate the effect of VR natural scene on cognitive fatigue and further explored its underlying neurophysiological alterations with electroencephalogram (EEG) microstates analysis.

Effects of parental psychological control on mobile phone addiction among college students: the mediation of loneliness and the moderation of physical activity.

Objective: Prior studies have shown that parental psychological control is linked to an increased risk of mobile phone addiction. Nevertheless, few studies have analyzed the potential mechanisms that may mediate or moderate this association. This study aims to investigate the role of loneliness as a mediator in the relationship between parental psychological control and mobile phone addiction, as well as the potential moderating effect of physical activity on this mediation process.

Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.

Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn/SA-PBA network crosslinked via multiple physicochemical interactions.

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry.

Background: Gut commensal microbiota has been identified as a potential environmental risk factor for multiple sclerosis (MS), and numerous studies have linked the commensal microorganism with the onset of MS. However, little is known about the mechanisms underlying the gut microbiome and host-immune system interaction.

Methods: We employed bioinformatics methodologies to identify human microbial-derived peptides by analyzing their similarity to the MHC II-TCR binding patterns of self-antigens.

Antibiotics versus Non-Antibiotic in the treatment of Aspiration Pneumonia: analysis of the MIMIC-IV database.

Background: Aspiration pneumonia (AP) is a common complication in the intensive care unit (ICU), which is associated with significantly increased morbidity and mortality and has a significant impact on patient prognosis. Antibiotics are commonly used in the clinical treatment of AP. However, the prognostic impact of antibiotics on patients with AP has not been adequately characterized.

NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice.

Background: Alcoholic liver disease (ALD) patients with bacterial infections usually exhibit high mortality rates. Infections frequently involve bacteria such as Vibrio vulnificus and Enterococcus faecalis. Nevertheless, the mechanisms predisposing ALD patients to bacterial infections and the role of the NLRP3 inflammasome in the intestinal epithelial barrier in ALD remain unclear.

Objective assessment of cognitive fatigue: a bibliometric analysis.

Aim: The objective of this study was to gain insight into the nature of cognitive fatigue and to identify future trends of objective assessment techniques in this field.

Methods: One thousand and eighty-five articles were retrieved from the Web of Science Core Collection database. R version 4.

A bearing fault diagnosis method for unknown operating conditions based on differentiated feature extraction.

Under unknown operating conditions, the domain generalization approach based on domain metrics is commonly used for rolling bearing fault diagnostics. Nevertheless, in the event of equipment failure under unknown operating conditions, focusing solely on the transferable characteristics across domains may result in the unintentional neglect of domain-specific features. To address the problems mentioned, the present study introduces a feature decomposition learning method that simultaneously extracts inter-domain transferable and domain-specific features.

Trophic transfer induced gut inflammation, dysbiosis, and inflammatory pathways in zebrafish via Artemia franciscana: A differential analysis of nanoplastic toxicity.

Rising glbal population and plastic consumption have caused a dramatic increase in plastic waste, leading to micro- and nanoplastic ingestion by aquatic organisms and subsequent bioaccumulation in their tissues. This transfer to higher trophic levels raises nanoplastic concentrations and bioavailability, potentially harming organisms' health and development. This poses a risk to human health via seafood.

Primary cutaneous cribriform tumor: A case report and literature review.

In the updated 5th edition of the WHO Classification of Skin Tumors, primary cutaneous cribriform carcinoma has been renamed cribriform tumor. This entity is a rare sweat gland neoplasm with undetermined malignant potential, with only 46 cases reported to date. Herein, we present a case of a 30-year-old female with a solitary nodule in the left thigh subcutaneous tissue.

Rolling bearings fault diagnosis based on two-stage signal fusion and deep multi-scale multi-sensor network.

In order to realize high-precision diagnosis of bearings faults in a multi-sensor detection environment, a fault diagnosis method based on two-stage signal fusion and deep multi-scale multi-sensor networks is proposed. Firstly, the signals are decomposed and fused using weighted empirical wavelet transform to enhance weak features and reduce noise. Secondly, an improved random weighting algorithm is proposed to perform a second weighted fusion of the signals to reduce the total mean square error.

Exploring the genetic causal relationship between physical activity and migraine in European population based on Mendelian randomization analysis.

Background: Previous studies have shown a connection between physical activity and migraines, but they don't prove a cause-and-effect relationship due to potential biases in observational methods.

Methods: Utilizing accelerometer-measured physical activity data from a cohort of 377,234 participants in the UK Biobank and information from 599,356 European migraine patients (including 48,975 cases and 550,381 controls) obtained from 24 cohorts, we performed a bidirectional Mendelian randomization analysis to investigate the genetic bidirectional causal relationship between accelerometer-measured physical activity and migraines.

Results: Research findings indicated a slight negative genetic correlation between "average acceleration" physical activity (  = -0.

Preparation of cellulose derived carbon/reduced graphene oxide composite aerogels for broadband and efficient microwave dissipation.

The development of cellulose derived carbon-based composite aerogels with light weight, broad bandwidth and strong absorption remains a challenging task. In this work, the cellulose derived carbon/reduced graphene oxide composite aerogels were prepared by a two-stage process of chemical crosslinking and high-temperature carbonization. The results revealed that the as-fabricated binary composite aerogels had a unique lightweight characteristic and three-dimensional porous network structure, which was chemically crosslinked by epichlorohydrin.

The effects of exercise on FGF21 in adults: a systematic review and meta-analysis.

Background: Fibroblast growth factor 21 (FGF21) is a key hormone factor that regulates glucose and lipid homeostasis. Exercise may regulate its effects and affect disease states. Therefore, we sought to determine how exercise affects FGF21 concentrations in adults.

A comprehensive analysis of antibiotic resistance genes in the giant panda gut.

In this study, we have successfully constructed a comprehensive database of metagenome-assembled genomes (MAGs) pertaining to the gut microbiota of the giant panda. Through our analysis, we have identified significant reservoirs of antibiotic resistance genes (ARGs), namely , and . Furthermore, we have elucidated the primary contributors to ARGs, including and , in both captive and wild pandas.

The Effect of Physical Activity on Sleep Quality Among Chinese College Students: The Chain Mediating Role of Stress and Smartphone Addiction During the COVID-19 Pandemic.

Purpose: During the period of COVID-19 pandemic, the social restrictions and isolation exerted a significant impact on the sleep quality of Chinese college students. This study aims to delve into the influence of physical activity on the sleep quality of college students as well as the mediating roles of stress and smartphone addiction.

Materials And Methods: A cohort of 274 eligible college students (146 males and 128 females) were selected for the investigation.