Sleep-Associated Traits and Hearing Difficulties in Noise: A Bidirectional Mendelian Randomization Study.

Objectives: The aim of this study was to investigate the causal relationships between sleep-associated traits and hearing difficulties in noise (HDinN) by Mendelian randomization (MR) analysis.

Design: Single nucleotide polymorphisms associated with chronotype, insomnia, sleep duration, daytime dozing or sleeping, and ease of getting up in the morning were extracted from European population genome-wide association study pooled data for bidirectional MR analysis. The MR-Egger regression, the inverse variance weighted technique, and the weighted median method were used for data analysis.

Five undescribed chromone-phenylpyridone hybrids from Cineraria repanda-derived Penicillium oxalicum with cytotoxic and antibacterial activity.

Five previously undescribed phenylpyridones, designated as citridones H-L (1-5), along with seven known compounds, were characterized from the rice medium culture of the Cineraria repanda-derived endophytic fungus Penicillium oxalicum. Their structures were elucidated through detailed interpretation of UV, NMR, and HR-ESI-MS data. The absolute configurations of C-2 and C-3 in compounds 1-4 were determined by spectroscopic analysis and ECD calculations, while the C-5' configurations were established through computational C NMR and DP4+ analyses.

Fluid volume status detection model for patients with heart failure based on machine learning methods.

Backgroud: Fluid volume abnormalities are a major cause of exacerbations in heart failure patients. However, there is few efficient, rapid, or cost-effective clinical approach for determining volume status, resulting in inadequate or unsatisfactory treatment. The aim was to develop an early fluid volume detection model for heart failure patients utilizing a machine learning stratification.

Short communication: Upregulation of hypoxia/reoxygenation-induced Shc3 by downregulated miR-455-5p, suppresses trophoblast invasion and is associated with placental inflammation and angiogenesis in preeclampsia.

Preeclampsia is characterized by insufficient invasion of extravillous trophoblasts and is a consequence of failed adaption of extravillous trophoblasts to changes in the intrauterine environment developing embryo. Specific miRNAs are implicated in the development of preeclampsia (PE). miR-455-5p is present at low levels in PE but its role is not known.

A machine learning-based immune response signature to facilitate prognosis prediction in patients with endometrial cancer.

Endometrial cancer is the most prevalent form of gynecologic malignancy, with a significant surge in incidence among youngsters. Although the advent of the immunotherapy era has profoundly improved patient outcomes, not all patients benefit from immunotherapy; some patients experience hyperprogression while on immunotherapy. Hence, there is a pressing need to further delineate the distinct immune response profiles in patients with endometrial cancer to enhance prognosis prediction and facilitate the prediction of immunotherapeutic responses.

Identification and comparative genomic analysis of endophytic fungi in Bletilla striata and its potential for promoting militarine bioaccumulation.

Bletilla striata (Thunb.) Reichb.f is renowned for its traditional medicinal applications and a spectrum of pharmacological activities, which is intricately linked to militarine.

enhances dextran sulfate sodium-induced colitis by promoting nf-κB-NLRP3-Dependent macrophage pyroptosis.

Evidence indicates that gut microbiota is crucial in ulcerative colitis (UC) development. Increased species abundance is linked to UC, but its role and mechanisms in intestinal inflammation are not well understood. This study used a dextran sulfate sodium (DSS)-induced colitis model in mice, and different bacterial strains were administered via gavage.

Self-adhesion conductive cardiac patch based on methoxytriethylene glycol-functionalized graphene effectively improves cardiac function after myocardial infarction.

Introduction: Abnormal electrical activity of the heart following myocardial infarction (MI) may lead to heart failure or sudden cardiac death. Graphene-based conductive hydrogels can simulate the microenvironment of myocardial tissue and improve cardiac function post-MI. However, existing methods for preparing graphene and its derivatives suffer from drawbacks such as low purity, complex processes, and unclear structures, which limiting their biological applications.

The Impact of the Triglyceride-Glucose Index on the Development of Depression in Patients with Coronary Atherosclerotic Heart Disease.

Background: Depression is common among patients with coronary atherosclerotic heart disease and is a prevalent mental health issue, particularly among those with cardiovascular diseases. Depression is commonly associated with elevated blood glucose and lipid levels. The triglyceride-glucose index is a novel indicator reflecting insulin resistance, which has been proven in numerous studies to be associated with cardiovascular diseases.

Absorptive metasurface with optical transparency for broadband RCS reduction.

Here, we introduce an optically transparent and flexible metasurface designed for effective absorption within the microwave spectrum. Indium tin oxide (ITO) films with varying square resistances fabricate a metasurface ground layer and a lossy pattern layers. Polydimethylsiloxane (PDMS) with a low refractive index, high transparency, and high flexibility is chosen as the dielectric layer.

Government Support, Community Recreation Facilities, and Physical Activity in China: A Cross-Sectional Socioecological Analysis.

Background: In the context of rising noncommunicable diseases, Chinese authorities emphasize the need for local governments to provide public sports services to support physical activity (PA).

Methods: Employing a socioecological theoretical framework, and drawing on a hierarchical data set synthesized from the China Health and Nutrition Survey, China Stock Market & Accounting Research Database, and Wind Financial Terminal from 2015, a multilevel analysis of the association between provincial government expenditure on culture, sports, and media from 12 provinces, the recreation facilities provided by 287 communities, and PA of n = 10,305 individuals is performed. The number of, and time allocated to, PAs undertaken as well as their METs equivalent in relation to World Health Organization guidelines are investigated.

Synthesis of a novel BiClS/BiMoO Z-type heterojunction for efficient photocatalytic removal of tetracycline antibiotic and Cr(VI): Intermediate toxicity and mechanism insight.

Novel BiClS/BiMoO (BCS/BMO) Z-type heterojunctions were synthesized using a straightforward hydrothermal method. Benefiting from the large specific surface area (62.41 m/g) and the effective separation of photogenerated carriers facilitated by the Z-scheme heterojunction, the BCS/BMO exhibited remarkable improved photocatalytic tetracycline degradation and Cr(VI) reduction efficiency in comparison to BCS, BMO, and their physical mixture.

Cadmium-induced protein AS8: A protein to improve Cd accumulation and transport via Cd uptake in poplar.

The pollution of soil with heavy metals (HMs) has become an environmental problem of global concern. Phytoremediation, whereby plants extract HMs from soil, can efficiently and substantially reduce HM pollution in soil in an environmentally friendly manner. Cadmium-induced protein AS8 (CIPAS8) is present in many plants and its expression is induced by HMs.

mA methyltransferase ZC3H13 improves pulmonary fibrosis in mice through regulating Bax expression.

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease. N6-methyladenosine (mA) is a reversible RNA modification that was shown to be associated with IPF development. The present study aimed to explore the function and potential mechanism of the mA methylation enzyme zinc finger CCCH-type containing 13 (ZC3H13) in IPF.

Copper-Catalyzed Asymmetric Hydrogenation of Unsymmetrical ortho-Br Substituted Benzophenones.

The asymmetric hydrogenation of benzophenones, catalyzed by low-activity earth-abundant metal copper, has hitherto remained a challenge due to the substrates equipped with two indistinguishably similar aryl groups. In this study, we demonstrated that the prochiral carbon of the ortho-bromine substrate exhibits the highest electrophilicity and high reactivity among the ortho-halogen substituted benzophenones, as determined by the Fukui function (f) analysis and hydrogenation reaction. Considering that the enantiodirecting functional bromine group can be easily derivatized and removed in the products, we successfully achieved a green copper-catalyzed asymmetric hydrogenation of ortho-bromine substituted benzophenones.

Engineering Three-Dimensional Interconnected Pores with Plentiful Edge Sites via a Confined Space for Enhanced Oxygen Reduction.

N-Doped carbon sheets based on edge engineering provide more opportunities for improving oxygen reduction reaction (ORR) active sites. However, with regard to the correlation between porous structural configurations and performances, it remains underexplored. Herein, a silica-assisted localized etching method was employed to create two-dimensional mesoporous carbon materials with customizable pore structures, abundant edge sites, and nitrogen functionalities.

A Novel Tongue Coating Segmentation Method Based on Improved TransUNet.

Background: As an important part of the tongue, the tongue coating is closely associated with different disorders and has major diagnostic benefits. This study aims to construct a neural network model that can perform complex tongue coating segmentation. This addresses the issue of tongue coating segmentation in intelligent tongue diagnosis automation.

Elevated serum neurofilament light chain levels are associated with hepatic encephalopathy in patients with cirrhosis.

Increasing evidences implicate vital role of neuronal damage in the development of hepatic encephalopathy (HE). Neurofilament light chain (NfL) is the main frame component of neurons and is closely related to axonal radial growth and neuronal structural stability. We hypothesized that NfL as a biomarker of axonal injury may contribute to early diagnosis of HE.