Publications by authors named "Guagnying Du"
Continuous dopaminergic stimulation (CDS) has become an important strategy for the development of drugs to treat Parkinson's disease (PD). Rotigotine behenate extended-release microspheres (RBEM) for injection represents a new treatment regime for CDS and is being applied for clinical trial. Our study in cynomolgus monkeys was a 20-week repeat dose toxicity investigation with RBEM at dosages of 90, 180, 360, with a 12-week recovery period.
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- * A series of tests showed that RBEM does not cause genotoxicity (DNA damage) in various cell types.
- * However, RBEM demonstrated toxicity effects on fertility and early embryonic development in female rats when administered at certain doses.