Association of the -629C>A (rs1800775) Polymorphism with the Development of Essential Hypertension in Mexican Population.

Polymorphisms in the gene promoter have been associated with cardiovascular risk and lipid alterations; however, their role in the development of hypertension has not been extensively explored. We evaluated four polymorphisms of the gene -827C>T, -631C>A, -630C>A, and -629C>A in patients with essential hypertension (EH). A total of 160 hypertensive (HT) patients and 160 normotensive (NT) individuals were studied.

Associations between dietary patterns and metabolic syndrome in adolescents.

Objective: Evaluate association of dietary patterns with metabolic syndrome (MetS) and metabolic markers.

Materials And Methods: 654 adolescents from Guadalajara, Jalisco, participated in a cross-sectional study. Diet was evaluated using a food frequency questionnaire; 24 food groups were integrated, and dietary patterns were derived using cluster analysis.

Interleukin-1 Alpha Polymorphisms Are Associated With Body Mass Index in Male But Not in Female Adolescents.

Background: The Interleukin (IL)-1 family of cytokines plays a key role in the inflammatory response. Genes coding for IL-1α, IL-1β, and IL-1Ra are located together as a block gene known as the IL-1 cluster. This genomic region shows wide nucleotide variability, and some polymorphisms have been widely studied and associated with features related to the metabolic syndrome.

Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Diabetic Patients and Its Association with Early Nephropathy.

Introduction: Diabetic nephropathy is a leading cause of chronic kidney disease (CKD). In diabetes, changes in serum levels of both soluble alpha Klotho (sKL) and fibroblast growth factor 23 (FGF-23) have been associated with CKD progression.

Objective: To evaluate the associations of circulating levels of sKL and FGF-23 with the presence of early nephropathy (EN) in diabetic patients.

Bullying and health-related quality of life in children and adolescent Mexican students.

Previous studies have reported a relationship between being a victim of bullying, but no studies have been carried out with Mexican students; notwithstanding the high scores of bullying in Mexico in international rankings. The objective of this study was to analyze the association between being a victim of bullying and lower HRQoL among schoolchildren and adolescents in Mexico. This cross-sectional and correlational study involved 2225 students from 22 elementary, middle and high schools.

Metabolic and genetic markers' associations with elevated levels of alanine aminotransferase in adolescents.

Background: Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in adolescents, is a feature of metabolic syndrome (MetS). Obesity and insulin resistance (IR) are risk factors for NAFLD, as well as inflammation-related genetic markers. The relationship between metabolic or inflammation-related genetic markers and alanine aminotransferase (ALT) is not fully understood.

Analysis of cytokine gene polymorphisms in Mestizo and native populations from Mexico.

Objectives: To determine whether the well-known genetic structure of the Mexican population observed with other multiallelic markers can be detected by analyzing functional polymorphisms of cytokine and other inflammatory-response-related genes.

Methods: A total of 834 Mestizo individuals from five Mexican cities and 92 Lacandonians - an Amerindian group from southeastern Mexico - were genotyped for 14 polymorphisms in the CRP, IL10, IL6, TGFB1, TNFA, LTA, ICAM1 IFNG, and IL1RN genes. Allele and haplotype frequencies were used for genetic structure analysis using F-statistics pairwise distances and multidimensional scaling plot.

A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents.

We examined the frequency of elevated urine albumin concentration (UAC) and its association with metabolic syndrome (MetS) and metabolic markers in 515 nondiabetic Mexican adolescents stratified by family history of diabetes (FHD). UAC was measured in a first morning urine sample and considered elevated when excretion was ≥20 mg/mL. MetS was defined using International Diabetes Federation criteria.

Association of polymorphisms of genes involved in lipid metabolism with blood pressure and lipid values in mexican hypertensive individuals.

Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP). We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5 rs3135506, APOB rs1042031, FABP2 rs1799883, LDLR rs5925, LIPC rs1800588, LPL rs328, and MTTP rs1800591) with blood pressure and lipid values in Mexican hypertensive (HT) patients. A total of 160 HT patients and 160 normotensive individuals were included.

[Physical activity, sedentary behavior and quality of life in undergraduate adolescents of Ciudad Guzman, State of Jalisco, Mexico].

With the aim of evaluating the association between physical activity and sedentary behavior with quality of life (QoL) in undergraduate students of Ciudad Guzman, state of Jalisco, Mexico, a total of 881 adolescents aged between 17 and 19 were studied. Online questionnaires were used, namely the research version of the Youth Quality of Life Instrument and the Youth Risk Behavior Survey. Odd ratios (OR) were obtained using simple and multivariate logistic regression analysis.

[Perceived or BMI-measured overweight and weight control behaviors in undergraduate adolescents from Ciudad Guzmán, Jalisco, México].

The aim was to evaluate associations between weight control behaviors and overweight measured by BMI, overweight perception or inaccurate weight perception. 492 undergraduate adolescents from 17 to 19 years old participated in the study. A self-administered questionnaire on line was applied and weight and height were measured.

Interleukin-6 polymorphisms are associated with obesity and hyperglycemia in Mexican adolescents.

Background And Aims: Interleukin-6 is an inflammatory response mediator used as a metabolic marker of obesity. Polymorphisms IL6 -597C>A, -572G>C, and -174G>C modify the production of this protein. The associations between these haplotypes and obesity or metabolic markers have not been studied in adolescents, so an analysis of these associations was performed.

The effects of social networks on tobacco use among high-school adolescents in Mexico.

Objective: To identify the effect of centrality in social network positions on tobacco-use among high-school adolescents in Tonala, Jalisco, Mexico.

Materials And Methods: Longitudinal sociometric social network data were collected among 486 high-school adolescents in 2003 and 399 in 2004. The survey included: social network components, smoking and sociodemographic characteristics.

Influence of CRP, IL6, and TNFA gene polymorphisms on circulating levels of C-reactive protein in Mexican adolescents.

Background And Aims: Obesity correlates with a chronic and low-grade inflammation status. C-reactive protein (CRP) measurement has been used as an independent risk marker for future cardiovascular events. CRP level shows interindividual variability due to environmental and genetic factors.

[Association of the network and social influence with tobacco use in high school students].

Objective: to associate network and social influence with tobacco use in high school students.

Methods: comparative cross sectional study. Four hundred and eighty six students participated.

Triglycerides and high-density lipoprotein cholesterol are associated with insulinemia in adolescents.

Objective: The aim of this study was to evaluate the association between lipids and insulin concentration in adolescents.

Material And Methods: A cross-sectional study of 350 adolescents aged 14-19 years old from a public high school in Guadalajara, in the state of Jalisco, Mexico, was conducted. Fasting insulin concentration was determined using microparticle enzyme immunoassay; total cholesterol and triglycerides were detected by standard enzymatic procedures;and low- and high-density lipoproteins were found using standard precipitation methods.