Regorafenib and trifluridine/tipiracil in real clinical practice.

Background: Colorectal cancer is the ninth leading cause of death in Spain. The latest therapeutic developments in the advanced stages of this disease are the oral drugs trifluridine/tipiracil and regorafenib.

Objective: Results of clinical trials (CTs) are not in real conditions and therefore, we want to study the effectiveness and the safety profile in the usual clinical practice and compare it with the bibliography.

Stability of lipid emulsion in total parenteral nutrition: An overview of literature.

Backgound And Aims: Total parenteral nutrition (TPN) is an extremely complex mixture. The multitude of chemical compounds involved can give rise to numerous reactions that condition its stability. We set out to review the existing literature on different issues related to stability, and which are still of concern in the hospital environment; such as the stability of the lipid emulsion.

Effectiveness, Safety, and Adherence to Treatment of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Real Practice.

Purpose: To evaluate the effectiveness, adverse reactions, and adherence to treatment of hypolipidemic inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9is) in a context of real clinical practice.

Methods: We present an observational, retrospective, descriptive, multicenter study of patients with hypercholesterolemia who began treatment with PCSK9is between January 2017 and December 2019, with a minimum treatment period of 3 months. The main variable we recorded was the frequency of cardiovascular events (cardiovascular death, myocardial infarction, stroke, coronary revascularization, and hospitalization for unstable angina) in patients treated with PCSK9is.

LEAN methodology: design and assessment of a standardized medication storage model.

Objective: The objective of this study was to assess the results of applying  Lean Methodology in the design of a standardized medication storage model in  hospitalization departments.

Method: Descriptive and retrospective study conducted between September 2017 and January 2019 in a tertiary level hospital. The Pharmacy Service led the creation of a multidisciplinary team.

Direct costs in patients with chronic inflammatory arthropathies on biological therapy: a real-world data study.

Objectives: The aim of the study was to assess the direct costs for the Spanish Health System of patients with chronic inflammatory arthropathies treated with biological therapies in daily clinical practice and to establish possible factors associated with lower costs.

Methods: A descriptive, observational and retrospective study was conducted. Patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis who started a biological therapy between 1 January 2009 and 31 December 2016 were included.

Biological therapy safety in chronic inflammatory arthropathy patients.

Objective: The marketing of biological therapies transformed the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. But there is still concern about patient safety and management in daily clinical practice. The aim of this study was to estimate risk factors of the adverse effects in a cohort of Spanish patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.

Medication persistence on biological therapies prescribed for the treatment of chronic inflammatory arthropathies: a real-world data study.

Objectives: Medication persistence, defined as the duration of time from its initiation to its discontinuation, is a surrogate for treatment effectiveness. The aim of the study was to evaluate persistence and causes of biological therapy (BT) suspension in patients with chronic inflammatory arthropathies: rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.

Methods: Single institution, descriptive, retrospective cohort study.

Standardization Consensus of a Hospital Drug Database: An Efficient Tool.

Background: Although the electronic prescribing software is the same for all hospitals of a regional health service, each has its own drug database, which it is responsible for maintaining. The aim of this study was to develop a consensus to standardize the hospital drug database of the electronic prescribing software, and to apply this tool to the electronic prescribing system of an oncology outpatient clinic of a Spanish tertiary-level hospital. Additionally, we sought to analyze the impact of the implemented actions on the health care services provided.

Biological therapy safety in chronic inflammatory arthropathy patients.

Objective: The marketing of biological therapies transformed the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. But there is still concern about patient safety and management in daily clinical practice. The aim of this study was to estimate risk factors of the adverse effects in a cohort of Spanish patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.

Content analysis of Twitter in relation to biological treatments for chronic inflammatory arthropathies: an exploratory study.

Objective: To analyse the volume and content of tweets in relation to biological treatments for chronic inflammatory arthropathies.

Methods: A Twitter analysis was carried out during one month using the following keywords: 'rheumatoid arthritis', 'ankylosing spondylitis', 'psoriatic arthritis' and their biological therapies: 'abatacept', 'adalimumab', 'certolizumab', 'etanercept', 'golimumab', 'infliximab' and 'tocilizumab'. Tweets were hand-coded and filtered for content.

Adherence to biological therapies in patients with chronic inflammatory arthropathies.

Introduction: The aims of the study were to quantify adherence, determine the factors that can  predict adherence and identify the consequences of poorer adherence in patients with chronic  inflammatory arthropathies treated with biological therapies in daily clinical practice.

Method: A descriptive, observational and retrospective study was carried out. Patients with  rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis who started a biologic therapy  between 1 January 2009 and 31 December 2016 were included.

Factors associated with patient satisfaction in an outpatient hospital pharmacy.

Objective: To analyse the factors leading to greater satisfaction among patients attending the outpatient hospital pharmacy (OPh).

Methods: A cross-sectional study was conducted of patients attending the OPh of a 1250-bed university hospital. A self-administered questionnaire for measuring outpatients' satisfaction was developed.

Devising of a risk map on the management of high risk alert medication in a high level university hospital.

Objective: To classify hospital units into three risk levels in order to define and prioritise  improvement and training measures in each of them.

Method: The risk map was developed in two phases: First phase involved the setting up of a  multidisciplinary team, a bibliographic search, the identification of medications and of the criteria to  design the map: (1) Location: number of high-alert medications; (2) Staff turnover: the units were  classified in low turnover units = 1, medium turnover units = 2 and high turnover units = 3 according  to data provided by the human resource department; (3) Frequency: quotient between the number of high alert medicactions in each unit and the total of medications used, and (4) Severity: voluntary  survey of professionals. An accumulated risk of severity of each unit was calculated: Σ (severity of the  drug x number of its units).

Model of teleconsultation pharmaceutical integrated in the electronic clinical history of the patient.

Objective: Describe the phases of implementation, scaling and integration of a  pharmacy teleconsultation model in electronic history, to coordinate the care  transition of patients.

Method: Descriptive and retrospective study in a health area of 500,000 inhabitants (3 years). In the first phase, a working group was created,  a communication platform was designed and a continuity program was piloted between a hospital pharmacist and the 13 primary care pharmacists.

Evaluation of the use of nab-paclitaxel and gemcitabine in clinical practice.

Context: Pancreatic cancer in a common tumor in our country for which there are various treatment alternatives.

Objective: Evaluate the effectiveness and safety of nab-paclitaxel and gemcitabine in everyday clinical practice.

Settings And Design: Observational, retrospective study at a tertiary university hospital.

Pharmacotherapeutic Reports as Tools for Detecting Discrepancies in Continuity of Care.

Background: The care transition is the time when more medication errors occur. The aim of this study is to analyze the usefulness of a pharmacotherapeutic report model at hospital discharge to prevent medication errors and to simplify pharmacotherapy during a patient's transition from the hospital to primary care.

Methods: Prospective study including patients diagnosed with chronic obstructive pulmonary disease who were admitted to a short-stay unit or an emergency room.

Experience with fampridine in clinical practice: analysis of a possible marker of clinical response.

Purpose Of The Study: Approximately 85% of patients with multiple sclerosis experience reduced mobility, which negatively affects quality of life. Fampridine is the first symptomatic treatment aimed at improving gait. We analyzed effectiveness and tolerance in clinical practice.

Multidisciplinary teams involved: detection of drug-related problems through continuity of care.

Objective: To quantify Drug-Related problems (DRPs) by establishing a Strategic Continuity of Care Program (e-Conecta- Concilia Program; e-CC) focused on the drug therapy of patients within an Integrated Management Structure, in order to guarantee the therapeutical efficiency, safety and traceability of patients.

Method: A prospective study at 8 months. The project included 22 Hospital Pharmacists and 12 Primary Care Pharmacists.

Short Stay Unit and Emergency Department: Pharmacotherapeutic Interventions and Its Impact.

The incidence of adverse effects in hospitals is very high and a lot of them are related to medication. The most important factor in pharmaceutical interventions to reduce adverse effects is medication reconciliation, and this process is indispensable during hospital care. Reasons for reconciliation errors are numerous but high-rotation care unit, such as emergency department and short stay units (SSUs) are more hazardous areas for patient safety.

Development of the management for parenteral nutrition traceability in a standard hospital.

Objective: to develop the traceability control and the hazard analysis in the processes of parenteral nutrients (PN).

Method: a standardized graphical notation was generated, describing in detail each of the stages in the overall process. The presence of hazards was analysed by sequencing decisions.

Pretreatment levels of the serum biomarkers CEA, CYFRA 21-1, SCC and the soluble EGFR and its ligands EGF, TGF-alpha, HB-EGF in the prediction of outcome in erlotinib treated non-small-cell lung cancer patients.

The aim of this study has been to investigate the potential of serum biomarkers used in clinical practice (CEA, CYFRA 21-1, SCC) together with the serum epidermal growth factor receptor (EGFR) and its associated ligands (EGF, TGF-α, HB-EGF) as outcome predictors of non-small cell lung cancer (NSCLC) patients treated with the TKI erlotinib. The pretreatment levels of these markers were evaluated through immunoassays carried out in 58 patients. The progression-free survival (PFS) and overall survival (OS) were assessed by the Kaplan-Meier method and differences between groups were compared by means of the Log-Rank test.

[Effect of pharmacologic treatment of the nutritional status of neurologic patients].

Clinical manifestations accompanying neurological diseases are diverse and affect multiple organs. Nutritional status of patients with certain neurological diseases such as stroke, Alzheimer's disease, Parkinson's disease, Epilepsy and Multiple Sclerosis can be altered because of symptoms associated with disease course, including certain micronutrient deficiency (folic acid, zinc, vitamin B6 and B12, vitamin D, vitamin E and vitamin C), changes in energy expenditure, intake decreased, gastrointestinal disorders and dysfunction of the bone mass. Also, we have to take in account other factors as: advanced age, multiple co morbidities, polypharmacy, the use of herbal products, social habits, diet and pharmacological treatments effect.

[Lipid profile analysis of two species of hake "merluccius capensis and merluccius paradoxus" and its contribution to cardiovascular disease prevention].

Introduction: In recent years it has been shown that omega-3 PUFAs have multiple cardiovascular protective effects. Currently, fish is the main and most important source of Omega-3 fatty acids.

Objective: To analyze the fatty acid composition in two species of hake, its content of omega-3 fatty acids and study their contribution to the prevention of cardiovascular diseases.