The Intracellular Growth of Is More Associated with High Glucose Levels Than with Impaired Responses of Monocytes from T2D Patients.

Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for () infection and the development of active tuberculosis. To evaluate whether infection susceptibility is associated with an intrinsic factor in monocytes from type 2 diabetes (T2D) patients or it is associated with hyperglycemia , we analyzed TLR-2 and TLR-4 expression by flow cytometry and the cytokines IL-1, IL-6, IL-8, IL-10, and TNF- by cytometric bead array assays, either stimulated with TLR-2 and TLR-4 ligands or infected with in the whole blood from T2D patients ( = 43) and healthy subjects ( = 26) or in CD14+ monocytes from healthy subjects cultured in high glucose (HG) (30 mM). The intracellular growth of was evaluated by CFU counts at 0, 1, and 3 days in both monocytes from T2D patients and monocytes from healthy subjects cultured in HG.

Low serum vitamin D levels in type 2 diabetes patients are associated with decreased mycobacterial activity.

Background: Concurrent diabetes mellitus and tuberculosis represent a significant health problem worldwide. Patients with diabetes mellitus have a high risk of tuberculosis, which may be mediated by an abnormal innate immune response due to hyperglycaemia or low vitamin D levels.

Methods: In the present study, we evaluated inactive vitamin D serum levels and the monocyte response to infection with M.

Oral Candida spp carriers: its prevalence in patients with type 2 diabetes mellitus.

Background: Prevalence of oral candidiasis in diabetic patients is 13.7-64%. Candida albicans was the most frequently isolated species (75-86.