Exploratory Investigation of Transcriptional Response during Exposure to Subinhibitory Concentration of Metronidazole.

, member from commensal gut microbiota, is an important pathogen associated to endogenous infections and metronidazole remains a valuable antibiotic for the treatment of these infections, although bacterial resistance is widely reported. Considering the need of a better understanding on the global mechanisms by which survive upon metronidazole exposure, we performed a RNA-seq transcriptomic approach with validation of gene expression results by qPCR. Bacteria strains were selected after subcultures with subinhibitory concentration (SIC) of the drug.