Publications by authors named "Gu-ying Zhang"
Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Infants.
Antimicrob Agents Chemother
April 2018
Ceftazidime, a third-generation cephalosporin, can be used for the treatment of adults and children with infections due to susceptible bacteria. To date, the pediatric pharmacokinetic data are limited in infants, and therefore we aimed to evaluate the population pharmacokinetics of ceftazidime in infants and to define the appropriate dose to optimize ceftazidime treatment. Blood samples were collected from children treated with ceftazidime, and concentrations of the drug were quantified by high-performance liquid chromatography with UV detection (HPLC-UV).
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- The study explored the effects of inhaled nitric oxide (iNO) on newborns with meconium aspiration syndrome (MAS), a condition that can cause severe respiratory issues.
- Patients diagnosed with severe MAS were randomly assigned to either receive iNO or standard treatment without it, focusing on their oxygen levels and overall outcomes.
- Results showed no significant differences between the two groups concerning key factors like gestational age or birth weight, indicating similar baseline characteristics for both treatments.