[Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury].

In this paper, Xixian Tongshuan Preparation was used as the research object, and all the chemical components of the 13 traditional Chinese medicines were collected. The target finding technique was used to obtain the key targets of the neuroprotective effect of Xixian Tongshuan Preparation, including 5 glutamate receptors, TGFR-1 and VEGFR-2. Molecular docking technology was used to screen out the potential active components of the above targets and to analyze their mechanism of action.

[Anti-platelet aggregation mechanism of Xixian Tongshuan Preparation based on molecular simulation methods].

The thrombus is a deposit that is formed on the surface of the endovascular or at the site of repair,and known as the main complication of cardiovascular disease and the cause of death. At the same time,thrombus is mainly treated by the following three ways: anticoagulation,anti-platelet aggregation and thrombolysis. In this study,the chemical constituents of seven traditional Chinese medicines in the Xixian Tongshuan Preparation were collected to construct a component database.

Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia.

Transcription factor 21 () has been identified as a candidate tumor suppressor gene which was epigenetically inactivated in a variety of human cancers. However, methylation pattern remains unknown in hematologic malignancies. The aim of this study was to investigate methylation and its clinical relevance in myelodysplastic syndrome (MDS) and non-M3 acute myeloid leukemia (AML).

Clinical trial cohort selection based on multi-level rule-based natural language processing system.

Objective: Identifying patients who meet selection criteria for clinical trials is typically challenging and time-consuming. In this article, we describe our clinical natural language processing (NLP) system to automatically assess patients' eligibility based on their longitudinal medical records. This work was part of the 2018 National NLP Clinical Challenges (n2c2) Shared-Task and Workshop on Cohort Selection for Clinical Trials.

Photon-Induced Reshaping in Perovskite Material Yields of Nanocrystals with Accurate Control of Size and Morphology.

Benefiting from morphology-/size-tunable optical features, nanocrystals have been considered promising candidates for display or lighting applications. To achieve selective characteristic emission, precise control in size and morphology is thus a prerequisite. Herein, we report that the nanosecond-pulsed laser irradiation induces CsPbBr reshaping, yielding precise control of size and morphology.

BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia.

Background: BCL2 protein inhibitor venetoclax (ABT-199) has been authorized by Food and Drug Administration for relapsed/refractory chronic lymphoid leukemia with 17p deletion. Although venetoclax/ABT-199 also caused cell death in acute myeloid leukemia (AML), whether it could be applied to clinical treatment needs further studies. Here, we revealed clinical implication of BCL2 overexpression in de novo adult AML, and may provide theoretical basis for targeted therapy using venetoclax.

Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review.

GPA with pituitary involvement is a rare condition which is prone to be misdiagnosed. The aim of this study was to summarize clinical features of pituitary involvement in GPA and facilitate early diagnosis. Twelve GPA patients were retrospectively analyzed at a single hospital between 2000 and 2017.

Solution processed membrane-based wearable ZnO/graphene Schottky UV photodetectors with imaging application.

Flexible and wearable electrical devices have attracted extensive research attention in recent years. In the device fabrication process, the low-cost and compatibility with industrialized mass production are of great importance. Herein, membrane-based flexible photodetectors (PDs) based on Polyvinylidene Fluoride filter membrane with the structure of Ag nanowires (NWs)/ZnO NWs/graphene were fabricated by a full-solution method.

/ dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia.

() has been reported as a significant cancer-associated microRNA, which was often epigenetically silenced and acted as a tumor suppressor gene in diverse human solid tumors. Conversely, recent studies show that overexpression was identified in both adult and pediatric acute myeloid leukemia (AML), suggesting that it might play an oncogenic role of in AML. However, the role of during leukemogenesis remains to be elucidated.

Identification, genotyping, and pathogenicity of Trichosporon spp. Isolated from Giant pandas (Ailuropoda melanoleuca).

Background: Trichosporon is the dominant genus of epidermal fungi in giant pandas (Ailuropoda melanoleuca) and causes local and deep infections. To provide the information needed for the diagnosis and treatment of trichosporosis in giant pandas, the sequence of ITS, D1/D2, and IGS1 loci in 29 isolates of Trichosporon spp. which were isolated from the body surface of giant pandas were combination to investigate interspecies identification and genotype.

Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum.

Hepatic lipid accumulation is the most common pathological characteristic of alcoholic liver disease (ALD). In mammalian cells, excess neutral lipids are stored in lipid droplets (LDs). As a member of perilipin family proteins, Plin3 was recently found to regulate the LD biogenesis.

Air Quality and Health Cobenefits of Different Deep Decarbonization Pathways in California.

As the world's fifth-largest economy, California has committed to reduce its greenhouse gas (GHG) emissions by 80% below 1990 levels by 2050. While previous studies have shown that GHG reductions could synergistically decrease air pollutant emissions and protect public health, limited research has been conducted to compare the health cobenefits of different technology pathways toward deep decarbonization. Using an integrated approach that combines energy and emission technology modeling, high-resolution chemical transport simulation, and health impact assessment, we find that achievement of the 80% GHG reduction target would bring substantial air quality and health cobenefits.

Seismic evidence for a mantle suture and implications for the origin of the Canadian Cordillera.

The origin of the North American Cordillera and its affinity with the bounding craton are subjects of contentious debate. The mechanisms of orogenesis are rooted in two competing hypotheses known as the accretionary and collisional models. The former model attributes the Cordillera to an archetypal accretionary orogen comprising a collage of exotic terranes.

Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice.

Qi-Jing-Sheng-Bai granule (QJSB) is a newly developed traditional Chinese medicine (TCM) formula. Clinically, it has been used for the treatment of leucopenia. However, its pharmacological mechanism needs more investigation.

Self-template Synthesis of Metal Halide Perovskite Nanotubes as Functional Cavities for Tailored Optoelectronic Devices.

Intriguing optoelectronic features of low-dimensional perovskites drive researchers to develop novel nanostructures for exploring new photophysical properties and meeting the requirements of future practical applications. Here, we report the facile and universal synthesis of metal halide perovskite nanotubes (NTs) in a micro alkylammonium emulsion system for the first time. The [PbBr]-based NTs with a diameter of 300 nm and length of 100 μm were synthesized through the reaction of PbBr and long-chain bromide in advance, which can be controllably converted into general metal halide perovskite APbBr (A = Cs, FA, MA) with preserved tubular morphology by introducing the Cs, MA, and FA cations.

[Lipid regulation mechanism and dosage form selection of Xixian Tongshuan Preparation based on molecular simulation methods].

Atherosclerosis is the main cause of stroke, and dyslipidemia is the most important risk factor for atherosclerosis. In this paper, pharmacophore and molecular docking models of eight key lipid-lowering targets, namely NPC1 L1, HMG-CoA reductase, SQS, MTP, CETP, PPARα, LXRα and LXRβ, were used to screen out the small molecular database of traditional Chinese medicine(TCM), which was made up of ingredients of thirteen Chinese herbal medicines contained in Xixian Tongshuan Preparation. The screening results indicated that the preparation could showed an effect in regulating lipid on target NPC1 L1, HMG-CoA reductase, LXRβ and SQS through four groups of potential active compounds, namely prupersin A in peach kernel and suffruticoside A in gastrodiaelata, limocitrin-β-D-glucoside in Ligusticum chuanxiong, 2'-(2,3-dihydroxybenzoyl)-sweroside in Pinellia ternate and quercitrin in Panax notoginseng, 4-tert-butyl-2-[(5-tert-butyl-2-hydroxy-phenyl)methoxy-methyl]-6-(hydroxymethyl)phenol in Gastrodia elata.

Assessing aerosol indirect effect on clouds and regional climate of East/South Asia and West Africa using NCEP GFS.

Aerosols can act as cloud condensation nuclei and ice nuclei, resulting in changes in cloud droplet/particle number/size, and hence altering the radiation budget. This study investigates the interactions between aerosols and ice clouds by incorporating the latest ice clouds parameterization in an atmospheric general circulation model. The simulation shows a decrease in effective ice cloud crystal size corresponding to aerosol increase, referred to as the aerosol first indirect effect, which has not been comprehensively studied.

Impact of aerosols on reservoir inflow: A case study for Big Creek Hydroelectric System in California.

Accurate and reliable reservoir inflow forecast is instrumental to the efficient operation of the hydroelectric power systems. It has been discovered that natural and anthropogenic aerosols have a great influence on meteorological variables such as temperature, snow water equivalent, and precipitation, which in turn impact the reservoir inflow. Therefore, it is imperative for us to quantify the impact of aerosols on reservoir inflow and to incorporate the aerosol models into future reservoir inflow forecasting models.

Transmitted plasmonic colors with different overlays utilizing the Fano-resonance.

This study develops a large-area pixelated filter that can achieve colors covering the entire visible range with a fixed period under normal incidence. Vivid colors as blue, green, and yellow (peak efficiency of ~60%) are experimentally achieved based on a Fano-resonance by altering the overlay's refractive index, which is highly sensitive to the surrounding material. Furthermore, the feasibility of using this device in large-area color printing and index sensors is discussed in detail, wherein a large-area (3 cm × 3 cm) logo and a figure of merit of 254 are achieved.

Rheinic acid ameliorates radiation-induced acute enteritis in rats through PPAR-γ/NF-κB.

Background: Acute radiation enteritis (ARE), a common complication of intestinal caused by abdominal and pelvic radiation therapy. Rheinic acid is a major active ingredient derived from Rhubarb. Rhubarb could suppress inflammation, tumor, fibrosis oxidative damage.

Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours.

Introduction: Tumour-associated angiogenesis is associated with the malignancy and poor prognosis of glioma. Isocitrate dehydrogenase (IDH) mutations are present in the majority of lower-grade (WHO grade II and III) and secondary glioblastomas, but their roles in tumour angiogenesis remain unclear.

Methods: Using magnetic resonance imaging (MRI), the cerebral blood flow (CBF) of IDH-mutated glioma was measured and compared with the IDH-wildtype glioma.

Pharmacokinetics of imidocarb dipropionate in white-tailed deer (Odocoileus virginianus) after single intramuscular administration.

This study was designed to investigate the pharmacokinetics of imidocarb, a carbanilide derivative, in white-tailed deer (Odocoileus virginianus). The pharmacokinetic properties of a single intramuscular (IM) dose of imidocarb were determined in 10 deer. A single IM injection of 3.

Research on a New Localized Induction Heating Process for Hot Stamping Steel Blanks.

Localized induction heating with one magnetizer was experimentally analyzed in order to investigate the altering effect of the magnetizer on the magnetic field. A 22MnB5 blank for tailored property was locally heated to produce the parts of a car body in white, such as the B-pillars. A lower-temperature region with a temperature in the two-phase zone and a full-austenitic high-temperature region were formed on the steel blank after 30 s.

Comprehensive analysis of circular RNA profiling in AZD9291-resistant non-small cell lung cancer cell lines.

Background: Osimertinib (AZD9291), a third-generation EGFR-tyrosine kinase inhibitor, can effectively prolong survival in non-small cell lung cancer (NSCLC) patients with EGFR mutations, particularly T790M mutations; however, acquired resistance to AZD9291 is inevitable, thus exploration of the targets of resistance is urgent.

Methods: Considering the important role of circular RNAs (circRNAs) in cancers, we established AZD9291-resistant NSCLC cell lines (H1975/AZDR and HCC827/AZDR) and used microarray analysis to determine the circRNA expression profiles of the cells. The H1975/AZDR and HCC827/AZDR cell lines were induced by gradually increasing the drug concentration.