Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis.

The excessive proliferation of fibroblast-like synoviocytes (FLS) leads to synovial hyperplasia, a key pathological hallmark of rheumatoid arthritis (RA). Eupalinolide B (EB), a sesquiterpene lactone of Eupatorium lindleyanum DC., has anti-inflammatory effects and anti-proliferative activity in tumor cells.

Ionic liquid-modified magnetic covalent organic framework for the extraction of four pyrethroids in traditional Chinese herbs.

Efficient enrichment of analytes and purification of matrices are crucial for the highly sensitive detection and monitoring of pesticides in traditional Chinese herbs. This work prepared magnetic ionic liquid-controlled covalent organic framework (IL-COF@FeO) as the sorbent via a simple in-situ precipitation polymerization and thiolene "click" strategy. The IL-COF@FeO exhibited remarkable adsorption performance towards pyrethroids within 5 min.

Metabolic Fingerprint of Dual Body Fluids Deciphers Diabetic Retinopathy.

Diabetic retinopathy (DR) is a microvascular complication of diabetes, affecting 34.6% of diabetes patients worldwide. Early detection and timely treatment can effectively improve the prognosis of DR.

Evolutionary trajectories of immune escape across cancers.

Unlabelled: Immune escape is a critical hallmark of cancer progression and underlies resistance to multiple immunotherapies. However, it remains unclear when the genetic events associated with immune escape occur during cancer development. Here, we integrate functional genomics studies of immunomodulatory genes with a tumor evolution reconstruction approach to infer the evolution of immune escape across 38 cancer types from the Pan-Cancer Analysis of Whole Genomes dataset.

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway.

Background: Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). WRN is known to protect somatic cells including adult stem cells from premature senescence. Loss of WRN in mesenchymal stem cells (MSCs) not only drives the cells to premature senescence but also significantly impairs the function of the stem cells in tissue repair or regeneration.

A machine learning model the prediction of athlete engagement based on cohesion, passion and mental toughness.

Athlete engagement is influenced by several factors, including cohesion, passion and mental toughness. Machine learning methods are frequently employed to construct predictive models as a result of their high efficiency. In order to comprehend the effects of cohesion, passion and mental toughness on athlete engagement, this study utilizes the relevant methods of machine learning to construct a prediction model, so as to find the intrinsic connection between them.

The Improvement Effects of BC99 on Liver Function and Gut Microbiota of Long-Term Alcohol Drinkers: A Randomized Double-Blind Clinical Trial.

Background/objectives: With the improvement of living standards, alcoholic liver disease caused by long-term drinking has been a common multiple disease. Probiotic interventions may help mitigate liver damage caused by alcohol intake, but the mechanisms need more investigation.

Methods: This study involved 70 long-term alcohol drinkers (18-65 years old, alcohol consumption ≥20 g/day, lasting for more than one year) who were randomly assigned to either the BC99 group or the placebo group.

SiC MOSFET with Integrated SBD Device Performance Prediction Method Based on Neural Network.

The SiC MOSFET with an integrated SBD (SBD-MOSFET) exhibits excellent performance in power electronics. However, the static and dynamic characteristics of this device are influenced by a multitude of parameters, and traditional TCAD simulation methods are often characterized by their complexity. Due to the increasing research on neural networks in recent years, such as the application of neural networks to the prediction of GaN JBS and Finfet devices, this paper considers the application of neural networks to the performance prediction of SiC MOSFET devices with an integrated SBD.

The Expression Pattern and Functional Analysis of Extracellular Vesicle Long Non-Coding RNAs from Uterine Fluid During Implantation in Pig.

Long non-coding RNAs (lncRNAs) act as competing endogenous RNAs and play significant roles in porcine embryo development. Extracellular vesicles (EVs) in the uterine fluid (UF) can target and deliver maternal endometrial signalling molecules to embryonic trophoblast cells, exerting crucial regulatory effects during embryo implantation. However, the specific roles of lncRNAs carried by UF-EVs during the embryo implantation period have not been thoroughly reported in the literature.

BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation.

Acute alcoholic liver injury (AALI) remains a significant global health concern, primarily driven by oxidative stress. This study investigated the protective mechanisms of BC99 against alcohol-induced oxidative stress using a dual model in rats and Caenorhabditis elegans. In rats, excessive alcohol was predominantly metabolized via the CYP2E1 pathway, leading to severe oxidative stress.

A Facile Electrode Modification Approach Based on Metal-Free Carbonaceous Carbon Black/Carbon Nanofibers for Electrochemical Sensing of Bisphenol A in Food.

Bisphenol A (BPA) is a typical environmental estrogen that is distributed worldwide and has the potential to pose a hazard to the ecological environment and human health. The development of an efficient and sensitive sensing strategy for the monitoring of BPA residues is of paramount importance. A novel electrochemical sensor based on carbon black and carbon nanofibers composite (CB/f-CNF)-assisted signal amplification has been successfully constructed for the amperometric detection of BPA in foods.

Dynamics and regulatory roles of RNA mA methylation in unbalanced genomes.

-methyladenosine (mA) in eukaryotic RNA is an epigenetic modification that is critical for RNA metabolism, gene expression regulation, and the development of organisms. Aberrant expression of mA components appears in a variety of human diseases. RNA mA modification in has proven to be involved in sex determination regulated by and may affect X chromosome expression through the MSL complex.

Facile Synthesis of Functional Mesoporous Organosilica Nanospheres and Adsorption Properties Towards Pb(II) Ions.

We successfully synthesize monodisperse sulfhydryl-modified mesoporous organosilica nanospheres (MONs-SH) via one-step hydrolytic condensation, where cetyltrimethylammonium chloride and dodecyl sulfobetaine are employed as dual-template agents with (3-mercaptopropyl)triethoxysilane and 1,2-bis(triethoxysilyl)ethane as the precursors and concentrated ammonia as the alkaline catalyst. The prepared MONs-SHs deliver a large specific surface area (729.15 m g), excellent monodispersity, and homogeneous particle size.

Hinokinin Decreases Methamphetamine-Induced Hyperlocomotion via the Regulatory Effects on Dopamine Levels.

The global abuse of stimulant methamphetamine (METH) imposes a significant social burden. Despite this, effective therapeutic interventions for mitigating the harmful effects associated with METH-induced central nervous system (CNS) stimulation remain elusive. (hinoki), containing hinokinin as its active constituent, has been identified to exhibit CNS depressant properties.

Protective effects of small RNAs encapsulated in -derived exosomes against non-alcoholic fatty liver disease.

Introduction: , a traditional medicinal plant, is renowned for its therapeutic properties, including the promotion of anti-inflammatory and bile secretion. Notably, it has demonstrated efficacy in the treatment of jaundice. This study aimed to evaluate the potential of -derived exosomes (ACDEs) as a novel therapeutic approach in non-alcoholic fatty liver disease (NAFLD).

Clinical outcomes of arthroscopic modified suture augmentation versus InternalBrace™ reconstruction in the treatment of chronic ankle instability.

Background: At present, the modified suture augmentation (MSA) repair and the InternalBrace™ (IB) reconstruction techniques are commonly used for the treatment of chronic ankle instability (CAI). This study aimed to evaluate and compare the clinical efficacy of the MSA repair and IB reconstruction techniques, providing a reference for clinical practice.

Methods: After propensity score matching, 50 patients with CAI between May 2021 and May 2022 were included in this retrospective study.

Consensus statement for the diagnosis, treatment, and prognosis of kaposiform hemangioendothelioma.

Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that typically presents in infancy or early childhood. As awareness of KHE increases, it is imperative that the management of KHE be updated to reflect the latest evidence-based guidelines. The aim of this study was to integrate the literature and Chinese expert opinions to provide updated recommendations that will guide the diagnosis, treatment, and prognosis of patients with KHE.

Associations of Tea Consumption With the Risk of All-Cause and Cause-Specific Mortality Among Adults With Type 2 Diabetes: A Prospective Cohort Study in China.

Aims: To investigate the associations of tea consumption with all-cause and cause-specific mortality among type 2 diabetes mellitus (T2DM) Chinese patients.

Materials And Methods: The present study included 15 718 participants from the Comprehensive Research on the Prevention and Control of Diabetes between 2013 and 2014 in Jiangsu, China. Information on tea consumption (including frequency, amount, and duration) was collected at baseline using interviewer-administered questionnaires.

Trajectories of Maternal Urinary Iodine Concentration Are Associated With Gestational Diabetes Mellitus.

Objectives: The relationship between iodine status and gestational diabetes mellitus (GDM) is inconclusive. This study aimed to explore the trajectories of urinary iodine concentrations (UIC) in pregnant women before GDM diagnosis and to assess the associations between maternal UIC trajectories and the risk of developing GDM.

Methods: A prospective cohort study was conducted in China.

[Analysis of the current status and related factors of iodine nutrition levels among adults aged 18 years and above in Zhejiang Province in 2022].

To analyze the iodine nutrition status and its related factors among adults aged 18 years and above in Zhejiang Province in 2022. A multistage stratified sampling method was used to select 4 320 adults aged 18 years and above from 16 on-site survey sites in Zhejiang Province for the study. A questionnaire was used to investigate the general demographic information and personal dietary characteristics of the study participants.

Characteristics of functional constipation and analysis of intestinal microbiota in children aged 0-4 in Zunyi region.

Background: Functional constipation (FC) significantly impacts children's health. This study investigates the prevalence and microbiota characteristics of FC in children aged 0-4 years in Zunyi area.

Methods: From October to December 2023, 2039 children aged 0-4 years in Zunyi were selected using stratified sampling and cross-sectional survey methods.

Effects of Klotho in epilepsy: An umbrella review of observational and mendelian randomization studies.

Background: Klotho is a geroprotective protein which has been recognized for its anti-aging properties. Pre-clinical evidence suggested that boosting Klotho might hold therapeutic potential in ageing and disease. Epilepsy is a neurological disorder characterized by its recurrent seizures.

Water Quality and Kidney Health in Farming Communities.

Since the turn of the century, there has been an increase in the frequency of chronic interstitial nephritis in agricultural communities. This is particularly evident in young farm workers from equatorial regions, where the prevalence of chronic kidney disease cannot be explained by classical risk determinants or exposure to heat stress alone. Potentially causal agents have included organic and inorganic drinking water contaminants.

TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein.

Porcine epidemic diarrhoea virus (PEDV) is an enteric pathogen that causes acute diarrhoea, dehydration and high mortality rates in suckling pigs. Tripartite motif 8 (TRIM8) has been shown to play multiple roles in the host's defence against viral infections. However, the functions of TRIM8 in regulating PEDV infection are still not well understood.

Transformative Gamified Binocular Therapy for Unilateral Amblyopia in Young Children: Pilot Prospective Efficacy and Safety Study.

Background: Amblyopia is a common cause of visual impairment in children. Compliance with traditional treatments for amblyopia is challenging due to negative psychosocial impacts. Recent shifts in amblyopia treatment have moved from suppressing the dominant eye to enhancing binocular visual function.