Total thyroidectomy is associated with increased prevalence of permanent hypoparathyroidism.

Background: Thyroid disorders are very common in adults. Despite advances in conservative management, surgery remains a treatment modality of choice in many cases. The mortality and morbidity of thyroidectomy are low, but long-term postoperative hypoparathyroidism (HPT) remains a prominent complication of the procedure.

[Iodine supply and thyroid function in the group of healthy pregnant women living in Warsaw].

Unlabelled: Iodine deficiency and thyroid gland disorders are especially harmful for pregnant women and normal fetal development. After initiation in 1997 of obligatory iodine prophylaxis, Poland has been found since 2003 a country with sufficient delivery of this microelement. However, in the population of pregnant women, slight deficiency of this element still exists.

Insulin-like factor 3 -- a new hormone related to polycystic ovary syndrome?

Introduction: The aim of this study was to find a correlation between insulin-like factor 3 (INSL3) and androgens: androstenedione (A), free testosterone (fT), and total testosterone (T), in two groups of polycystic ovary syndrome (PCOS) women: those with a body mass index (BMI) lower than 25 kg/m(2) and those with a BMI higher than 25 kg/m(2). The association between INSL3 and other serum parameters: luteinising hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding globulin (SHBG) and glucose and insulin were also investigated.

Material And Methods: The study group comprised 37 PCOS women aged 27 ± 4 years.

Measuring salivary androgens as a useful tool in the diagnosis of polycystic ovary syndrome.

Introduction: Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies. Clinically it can present as oligo-/amenorrhoea, hyperandrogenism and/or fertility problems.

Material And Methods: The study involved 60 women admitted to the Department of Internal Medicine and Endocrinology at the Medical University of Warsaw.

Thyroid-associated orbitopathy in patients with Hashimoto's thyroiditis: a case report.

Thyroid-associated orbitopathy is a set of ophthalmic symptoms resulting from an autoimmune process in which the swelling of extraocular tissues leads to exophthalmos either caused by hypersecretion and accumulation of glycosaminoglycans in the orbit fibroblasts or being the result of inflammatory processes in the oculomotor. These changes cause eyeball motility disturbances, keratopathy, and the pressure on the optical nerve. Thyroid-associated orbitopathy accompanies Graves' disease in most cases, whereas the Hashimoto's disease in only 5%.

Allotransplantation of cultured parathyroid progenitor cells without immunosuppression: clinical results.

Background: Hypoparathyroidism is a well-known consequence of extensive thyroid and parathyroid surgery. Allotransplantation of cultured parathyroid cells can be considered as an alternative to vitamin D3 and calcium supplementation in treatment of hypoparathyroidism. We present the long-term allotransplant activity in 85 patients who had undergone cellular allotransplantation for surgical hypoparathyroidism.

DNA damage and its repair in lymphocytes and thyroid nodule cells during radioiodine therapy in patients with hyperthyroidism.

Radioiodine treatment of hyperthyroid patients with autonomous thyroid nodule leads to cellular DNA damage not only in thyrocytes but also in peripheral blood lymphocytes. The purpose of this study was to evaluate DNA breakage and base damage in thyrocytes and lymphocytes in patients treated with 131-I. In all the patients thyroid scintiscan was performed using 131-I.

[Effectiveness of iodine prophylaxis in hypertensive patients on salt restricted diet].

Background: Iodine prophylaxis in Poland started in 1935 however it has been interrupted during Second World War, and also in 1980. In January 1997 a new approach of preventing iodine deficiency was introduced as obligatory iodination model of household salt to be extent of 30 mg KI/kg. The aim of the study was to determine iodine intake after introduction of mandatory salt iodization in group of persons being on low salt diet because of hypertension.

[Diagnostic difficulties in Grave's orbitopathy--case report].

Graves' orbitopathy is caused by intraorbital inflammatory reaction due to autoimmune thyroid disease. In most cases the diagnosis is based on the coexistence of typical eye signs and hyperthyroidism symptoms. In presented case, the absence of thyroid dysfunction implicated performance of differential diagnosis.

[Iodine supply in school children three years after introduction of obligatory salt iodization].

Three years after introduction of obligatory salt iodization in Poland we evaluated iodine supply in children from Mazovia region. Urinary iodine concentration (UIC) was estimated in morning samples from 779 schoolchildren aged 6-14 years. Previous investigation 7 years ago revealed mild or moderate iodine deficiency in this area.

[Diagnosis and treatment of thyroid nodules].

The paper presents current diagnostic and therapeutic approach of thyroid nodules. TSH and iodine are the main goitrogenic agents, but there are also other auto- para-endocrinal factors that play very important roles in goiter growth as well as in the intrinsic growth potential of some thyroid follicular cells. The diagnosis of thyroid nodule demands further investigation such as thyroid function evaluation and distinction between benign from malignant nodules using FNAB.

Salt iodination as a effective method of iodine supplementation.

Background: In January 1997 a new approach to preventing iodine deficiency was introduced in Poland. The goal of the present study was to determine whether the mandatory iodization of kitchen salt (30 mg KI/kg) has had any impact on ioduria.

Material/methods: The study was performed on 29 healthy volunteers, aged 22-29 (average age 23.

[Subclinical hyperthyroidism ].

Subclinical hyperthyroidism is defined as normal thyroid hormone level in serum but low serum thyrotropin TSH concentration in an asymptomatic individuals. The article described prevalence, pathogenesis, causes, clinical symptoms and diagnostic criteria of subclinical hyperthyroidism and is especially focused on patients with this thyroid dysfunction induced increase risk for development of atrial fibrillation and a decrease in bone mass in the case of postmenopausal women. It is not clear whether and when this pathology should be treated but the problem is important because of 4% patients per year which can possible develop overt hyperthyroidism.

Effect of surgical technique in subtotal and bilateral thyroidectomy on risk of postoperative parathyroid insufficiency development--our experience.

One of the postoperative complications after strumectomy is hypoparathyroidism. Therefore, the purpose of our study was to evaluate the effect of the surgical technique on the development of parathyroid gland insufficiency in our group of patients. Subtotal, bilateral strumectomies were performed according to Rothmund's suggestions.

[Free serotonin level in the blood of patients with borderline and essential hypertension].

Serotonin appears to play an important part in the pathogenesis of essential hypertension. Various studies have shown, that the metabolism of serotonin may be disturbed in some pathological conditions for example in hypertension. It concerns also the changed mechanisms of uptake and release of serotonin.

Platelet activity, prostacycline metabolite, plasma lipids and sympathoadrenal activity in patients with borderline hypertension and a positive family history of hypertension.

The study included 30 patients with borderline essential hypertension (HPT) (21 with a positive family history of hypertension, mean age 24.6 years, 9 with a negative family history, mean age 27.2 years) and 10 normotensive controls (mean age 27.

[Intracellular electrolytes and selected biochemical parameters in patients with borderline arterial hypertension and positive family history of hypertension].

The studies involved 22 patients with borderline hypertension and familial history of the arterial blood hypertension (mean age 24.6 years) and 9 patients without familial history of hypertension (mean age 22.2 years).