[The occurrence of anemia in small cell lung cancer patients during first-line chemotherapy].

Unlabelled: Both the character of disease and its aggressive treatment--including cisplatin-based chemotherapy--reflected to fact that anemia is a frequent problem in SCLC patients. Moreover, the potential prognostic role of anemia is considered in this group of patients. The aim of the study was to analyze occurrence of anemia in SCLS patients subjected to first line chemotherapy with the special attention paid to its potential prognostic role.

[Surprisingly positive effect of palliative CAP chemotherapy of bone-disseminated, undifferentiated carcinoma of unknown primary origin in patient with low performance status according to WHO].

The paper presents the case of a 58-year old male with low performance status (3 according to WHO) diagnosed with bone-disseminated, undifferentiated carcinoma of unknown primary origin in April 2001. The patient was given reduced dosage CAP chemotherapy (cisplatin 40 mg/m2, doxorubicin 40 mg/m2, cyclophosphamide 40 mg/m2, every 21 days). A total number of 12 treatment courses were administered, reaching summary admissible dosage of doxorubicin.

E-cadherin and fibronectin expressions have no prognostic role in stage II ductal breast cancer.

Background: The aim of the study was to describe the expressions of E-cadherin (EC) and fibronectin (FN) and their prognostic value in radically-treated ductal breast cancer.

Patients And Methods: Ninety-eight patients, aged 26-86 (median, 57) with stage II G2 or G3 tumors, were subjected to a retrospective analysis.

Results: No significant associations were observed between the levels of the proteins studied and patient or cancer features, with the exception of relationships between FN expression and the histological grade of the tumor or hormonal status of the subjects.

Malignant melanoma with gall bladder metastasis as a second neoplasm in the course of prostate cancer.

Malignant melanoma is a neoplasm with an often unpredictable course and metastases potentially affecting all organs of the human body. Metastases into the gall bladder are rare. The role of hormonal background in the development and progression of malignant melanoma has not been established.

[Erb-2 overexpression in breast cancer].

Overexpression of the Erb B-2 receptor plays an important role in the pathogenesis of breast cancer. It results in the formation of heterodimers consisting of Erb-B2/Erb B-3 receptors which have an ability to produce stable and external factors independent mitotic stimuli. Together with an autocrine stimulation of neoplastic cell proliferation by heregulin and cyclooxygenase 2 activation it is a significant factor in carcinogenesis.