Publications by authors named "Grzegorz Gurynowicz"

The present study aimed to analyze the association between tumor budding index (TBI) and microvessel density (MVD) and selected clinicopathological features in female patients with endometrial cancer (EC). The present study included 137 patients, of whom 117 had endometrial endometrioid cancer and 3 had non-endometrioid EC (NEEC). Additionally, 8 cases of simple endometrial hyperplasia and 9 cases of atypical endometrial hyperplasia were included in the present study.

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Uterine fibroids (UFs) are benign tumors of female genital tract. Clinically symptomatic UFs may be a cause of serious health problems for many women worldwide. The optimal choice of a treatment method should fit a patient's specific life situation or expectancies (especially fertility) as much as possible.

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Objectives: Tumor endothelial marker 7 (TEM7) and nestin have been proposed to be new candidates for neoangiogenesis assessment. Nestin is also cancer stem cells marker in various malignant tumors.

Aims: To investigate the expression of TEM7, nestin and nestin-related microvessel density (MVD) in high-grade serous ovarian cancer samples and to study their correlation with overall survival (OS) and disease-free survival (DFS) times.

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Objectives: To investigate the possible association of vasculogenic mimicry (VM), VE-cadherin and MIG-7 expression with clinicopathological features of women with malignant ovarian masses.

Material And Methods: VM was studied with the PAS reaction and VE-cadherin was assessed with immunohistochemistry in 108 women with malignant ovarian tumors. Additionally, quantitative expression of MIG-7 mRNA was performed in 52 ovarian cancers with qRT-PCR.

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Benign uterine fibroids are common female genital tract tumors and if symptomatic often require extensive surgery. When tumors are multiple and large or unusually located, the operative treatment may lead to significant morbidity and compromise quality of life. Recovery period after surgical treatment may be complicated by patient's medical condition and wound healing problems.

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Method And Results: Between 1993 and 2000, 7529 patients underwent cesarean section (24.3% of 31,798 delivering women) at University Hospital in Poznań. There were 52 cases of simultaneous adnexal surgery among them because of ovarian tumors (1 case/144 abdominal deliveries; 1 case/612 pregnancies).

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Synopsis of recent research by authors named "Grzegorz Gurynowicz"

  • - Grzegorz Gurynowicz's research focuses primarily on gynecological oncology, particularly assessing tumor characteristics and treatment options for conditions such as endometrial and ovarian cancers, as well as benign uterine fibroids.
  • - His studies include evaluating prognostic markers like TEM7 and nestin in advanced ovarian cancer, the impact of tumor budding index and microvessel density in endometrial cancer, and the efficacy of high-intensity focused ultrasound therapy for treating symptomatic uterine fibroids.
  • - Gurynowicz's findings contribute valuable insights into the relationships between tumor biology, treatment outcomes, and patient well-being, highlighting the need for individualized therapeutic approaches in gynecologic cancer management.

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