Publications by authors named "Grzegorz Cofta"

Mycelium-based composites (MBCs) are alternative biopolymers for designing sustainable furniture and other interior elements. These innovative biocomposites have many ecological advantages but present a new challenge in aesthetics and human product acceptance. Grown products, made using living mycelium and lignocellulosic substrates, are porous, have irregular surfaces and have irregular coloring.

View Article and Find Full Text PDF

In the search for new bioactive compounds, a methodology based on combining two molecules with biological properties into a new hybrid molecule was used to design and synthesize of a series of ten indole derivatives bearing imidazole, benzothiazole-2-thione, or benzoxazole-2-thione moieties at the C-3 position. The compounds were spectroscopically characterized and tested for their antioxidant, antibacterial, and fungicidal activities. The crystal structures were determined for five of them.

View Article and Find Full Text PDF

Mycelium-Based Composites (MBCs) are innovative engineering materials made from lignocellulosic by-products bonded with fungal mycelium. While some performance characteristics of MBCs are inferior to those of currently used engineering materials, these composites nevertheless prove to be superior in ecological aspects. Improving the properties of MBCs may be achieved using an adequate substrate type, fungus species, and manufacturing technology.

View Article and Find Full Text PDF

Polymer composites with renewable lignocellulosic fillers, despite their many advantages, are susceptible to biodegradation, which is a major limitation in terms of external applications. The work uses an innovative hybrid propolis-silane modifier in order to simultaneously increase the resistance to fungal attack, as well as to ensure good interfacial adhesion of the filler-polymer matrix. Polypropylene composites with 30% pine wood content were obtained by extrusion and pressing.

View Article and Find Full Text PDF

Mycelium-based composites (MBCs) have attracted growing attention due to their role in the development of eco-design methods. We concurrently analysed scientific publications, patent documents, and results of our own feasibility studies to identify the current design issues and technologies used. A literature inquiry in scientific and patent databases (WoS, Scopus, The Lens, Google Patents) pointed to 92 scientific publications and 212 patent documents.

View Article and Find Full Text PDF

Earlier studies have revealed that wood treated with caffeine was effectively protected against decay fungi and molds. However, there is a need to establish how the caffeine molecule behaves after wood impregnation and how it can protect wood. The objective of the research was to characterize the interaction between caffeine and Scots pine ( L.

View Article and Find Full Text PDF

The article presents characteristics of wood/polypropylene composites, where the wood was treated with propolis extract (EEP) and innovative propolis-silane formulations. Special interest in propolis for wood impregnation is due to its antimicrobial properties. One propolis-silane formulation (EEP-TEOS/VTMOS) consisted of EEP, tetraethyl orthosilicate (TEOS), and vinyltrimethoxysilane (VTMOS), while the other (EEP-TEOS/OTEOS) contained EEP, tetraethyl orthosilicate (TEOS), and octyltriethoxysilane (OTEOS).

View Article and Find Full Text PDF

Complexes of colchiceine with monovalent cation perchlorates and iodides have been obtained and characterized by spectroscopic methods. DFT and spectroscopic studies reveal that the dihedral angle ω , crucial for colchicine biological mechanism of action, that is, binding to tubulins depends on the diameter of the complexed metal cation. Biological tests indicated no antifungal properties of colchicine (it was active only toward A.

View Article and Find Full Text PDF

A series of new semi-synthetic 7-deacetyl-10-alkylthiocolchicne derivatives with ethyl, -propyl, i-propyl and -butyl substituents were synthesised and characterised by spectroscopic methods, elemental analysis, DFT calculations and molecular docking simulations. All the synthesized compounds have been tested for fungicidal and anticancer activities against SKOV-3, LoVo, MCF-7, MDA-MB-231 and the lung-derived fibroblast CCD39Lu. All the new colchicine derivatives exhibit significantly higher cytotoxicity towards the SKOV-3 tumour cell line than the natural product - colchicine.

View Article and Find Full Text PDF

A scanning electron microscopy (SEM) investigation of pine (Pinus sylvestris) and oak (Quercus sp.) wood samples exposed to various types of natural degradation is presented with the aim of discussing the correct identification of multiple degradation signs in waterlogged wood. This is part of an experiment performed at the archeological site of Biskupin (Poland) to evaluate the dynamics of short-term wood degradation during reburial and the suitability of excavated wood as substrate for the fungal attack.

View Article and Find Full Text PDF