Publications by authors named "Gruver J"

Article Synopsis
  • The study aimed to evaluate whether the images of dermatologic conditions in a popular pediatric textbook accurately represent diverse skin tones, as pediatricians need to diagnose on various skin types.
  • Analysis of 515 figures showed that 93.6% depicted light skin tones, while only 6.4% showcased dark skin tones, which does not align with the demographic distribution of the US population.
  • The researchers found that specific skin conditions were predominantly illustrated on either light or dark skin, suggesting a potential bias in the textbook’s visual representation of pediatric dermatology that may affect diagnosis and treatment.
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Purpose Of Review: Provide an overview of recent findings and recommendations for the presentation, diagnosis, and management of pediatric dermatologic emergencies.

Recent Findings: Updated information on optimal diagnosis and treatments for pediatric dermatologic emergencies because of infection, reactive infectious mucocutaneous eruption, and serious cutaneous adverse reactions are covered.

Summary: Pediatric dermatologic emergencies require prompt diagnosis and management.

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Hyperkalemia is a common electrolyte disorder in patients with chronic kidney disease (CKD) that increases in prevalence with the decline of glomerular fltration rate (GFR). Another risk of hyperkalemia is the use of renin-angiotensin-aldosterone system inhibitors (RAASi) and/or mineralocorticoid receptor antagonists (MRAs) in managing CKD and proteinuria. The treatment of chronic hyperkalemia is challenging especially for outpatients.

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Article Synopsis
  • - Spindle cell rhabdomyosarcoma (RMS) is a rare cancer variant in infants, linked with gene fusions but less studied for treatment outcomes compared to older patients with different genetic profiles.
  • - A study of 40 infants treated for spindle cell RMS from 1997 to 2018 revealed a high success rate, with 95% achieving complete remission through a combination of surgery, chemotherapy, and sometimes radiotherapy.
  • - Overall survival rates for these infants were promising: 86% event-free and 91% overall at five years, although one case of metastatic disease resulted in a poor outcome despite treatment.
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Current research estimates hundreds of thousands of turbine-related bat fatalities in North America annually. In an effort to reduce impacts of wind energy production on bat populations, many facilities implement operational curtailment strategies that limit turbine blade rotation during conditions when nighttime wind speeds are low. Incorporating real-time bat activity data into wind speed-only curtailment (WOC) strategies may increase operational flexibility by allowing turbines to operate normally when bats are not present near turbines.

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The Hippo pathway regulates organ size, regeneration, and cell growth by controlling the stability of the transcription factor, YAP (Yorkie in ). When there is tissue damage, YAP is activated allowing the restoration of homeostatic tissue size. The exact signals by which YAP is activated are still not fully understood, but its activation is known to affect both cell size and cell number.

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The development and expansion of wind energy is considered a key global threat to bat populations. Bat carcasses are being found underneath wind turbines across North and South America, Eurasia, Africa, and the Austro-Pacific. However, relatively little is known about the comparative impacts of techniques designed to modify turbine operations in ways that reduce bat fatalities associated with wind energy facilities.

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Field trials were conducted from 2010 to 2013 at four locations in Illinois to evaluate the impact of cover crops (cereal rye [Secale cereal], brown mustard [Brassica juncea], winter canola [B. napus], and winter rapeseed [B. napus]) on soybean [Glycine max] stands and yield, diseases, pathogen populations, and soil microbial communities.

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Quantitative methods for species identification are commonly used in acoustic surveys for animals. While various identification models have been studied extensively, there has been little study of methods for selecting calls prior to modeling or methods for validating results after modeling. We obtained two call libraries with a combined 1556 pulse sequences from 11 North American bat species.

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Despite a broad literature addressing the human dimensions of wildfire, current approaches often compartmentalize results according to disciplinary boundaries. Further, relatively few studies have focused on the public's evolving perceptions of wildfire as communities change over time. This paper responds to these gaps by exploring perceptions of landscape dynamics and wildfire between 2003 and 2007 using a typological framework of intersecting ecological, social, and cultural processes.

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The structure of a unique C,N-chelated dilithio dianion has been established as a solvated monomeric species using a combination of NMR and computational techniques. The highly ordered structure of the dianion may be important in its reactivity in an oxidative C-N bond-forming process.

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Cell motility is a fundamental process with relevance to embryonic development, immune response, and metastasis. Cells move either spontaneously, in a nondirected fashion, or in response to chemotactic signals, in a directed fashion. Even though they are often studied separately, both forms of motility share many complex processes at the molecular and subcellular scale, e.

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The method of continuous variation in conjunction with (6)Li NMR spectroscopy was used to characterize lithium phenolates solvated by tetrahydrofuran and 1,2-dimethoxyethane. The strategy relies on the formation of ensembles of homo- and heteroaggregated phenolates. The symmetries and concentration dependencies of the heteroaggregates attest to the aggregation numbers of the homoaggregates.

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Previous study demonstrated that WASP localizes on vesicles during Dictyostelium chemotaxis and these vesicles appear to be preferentially distributed at the leading and trailing edge of migrating cells. In this study, we have examined the role of PCH family proteins, Nwk/Bzz1p-like protein (NLP) and Syndapin-like protein (SLP), in the regulation of the formation and trafficking of WASP-vesicles during chemotaxis. NLP and SLP appear to be functionally redundant and deletion of both nlp and slp genes causes the loss of polarized F-actin organization and significant defects in chemotaxis.

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The method of continuous variation was used to characterize lithium enolates, phenolates, carboxylates, and alkoxides solvated by N,N,N',N'-tetramethylethylenediamine (TMEDA). The method relies on characterizing an ensemble of homo- and heteroaggregates using (6)Li NMR spectroscopy. A combination of aggregate counts and symmetries, nearly statistical distributions, and quantitative parametric fits revealed that cyclic dimers are the dominant forms.

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The PI3K/PTEN pathway, as the regulator of 3'-phosphoinositide (3'-PI) dynamics, has emerged as a key regulator of chemoattractant gradient sensing during chemotaxis in Dictyostelium and other cell types. Previous results have shown 3'-PIs to be important for regulating basal cell motility and sensing the direction and strength of the chemoattractant gradient. We examined the chemotaxis of wild-type cells and cells lacking PTEN or PI3K1 and 2 using analytical methods that allowed us to quantitatively discern differences between the genotype's ability to sense and efficiently respond to changes in gradient steepness during chemotaxis.

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The method of continuous variation in conjunction with 6Li NMR spectroscopy was used to characterize lithium enolates derived from 1-indanone, cyclohexanone, and cyclopentanone in solution. The strategy relies on forming ensembles of homo- and heteroaggregated enolates. The enolates form exclusively chelated dimers in N,N,N',N'-tetramethylethylenediamine and cubic tetramers in tetrahydrofuran and 1,2-dimethoxyethane.

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Feces from 60 bats representing 5 species and 4 genera collected in central Wyoming in 2001 were examined for the presence of coccidia. Two species of Eimeria were identified in 4 bats representing 2 species of Myotis. All infected animals harbored a single species; there was no multispecies infection.

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The purpose of this study was to describe the initial steps in the role transition of graduate to staff nurse. During the first 3 weeks of an orientation to a clinical unit in an acute care hospital, graduate nurses and their preceptors used feedback sheets to document the learning activities of the graduate nurse, communicate the need for and evaluation of learning experiences, and plan activities to meet the continued needs of graduate nurses. Daily feedback sheets from 27 orientees and preceptors were analyzed using content analysis.

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