Increased microbial yield from continuous ambulatory peritoneal dialysis peritonitis effluent after chemical or physical disruption of phagocytes.

The laboratory diagnosis of continuous ambulatory peritoneal dialysis-associated peritonitis is often hindered by either the absence of or the recovery of low numbers of viable microorganisms. This may be the result of sequestration of bacteria within phagocytes. Sonication of clinical specimens prior to culturing or culturing on saponin-containing media resulted in the growth of significantly greater numbers of colonies than standard culturing on conventional media.

Chronic dog intestinal loop model for studying drug absorption as exemplified by beta-adrenoreceptor blocking agents, atenolol and propranolol.

Chronic in situ loops of dog small intestine (jejunum or ileum) were used to investigate the absorption of the beta-adrenoreceptor blocking agents atenolol and propranolol. Absorption measurements were made in conscious dogs by monitoring drug disappearance from solution in the loop, with correction for intestinal water absorption. The jejunum had a mean resting pH of 7.

Concentrations of the vasodilator isosorbide dinitrate and its metabolites in the blood of human subjects.

An oral dose of 5 mg of 14C-isosorbide dinitrate was rapidly absorbed, biotransformed and excreted by human subjects. Peak whole blood concentrations of radioactivity were reached after 1.5 to 2 hours and declined relatively slowly.