Anterior cervical disc herniation. Case report.

A 39-year-old man with an extrinsic esophageal lesion was found to have an anterior herniation of a soft degenerated cervical disc. Only two cases of symptomatic anterior cervical disc herniation have been reported previously. Dysphagia produced by anterior cervical osteophytes is more common and is a recognized clinical entity.

Gingival overgrowth induced by diltiazem. A case report.

Gingival overgrowth induced by diphenylhydantoin (Dilantin) has been well documented in the literature. Recently, there have been other medications with side effects causing Dilantin-like gingival overgrowth. This article presents a case in which diltiazem (Cardizem), a calcium-channel blocker, induced gingival overgrowth.

Incidence of anti-human Ig with restricted specificity in Japanese, Kuwaiti, and Swedish patients with rheumatoid arthritis.

Assuming that anti-allotypic anti-Ig in rheumatoid arthritis is stimulated by the individual's allotype, it would be reasonable to expect a higher incidence of anti-G1m(a) in individuals carrying G1m(a). There is marked divergence among various populations in allotype frequencies. G1m(a) allotype and the prevalence of anti-Ig reactive with G1m(a) Ig were determined in 18 Kuwaiti, 23 Japanese, and 41 Swedish rheumatoid arthritis patients.

The Gm system. Anti-Gm's: characteristics in rheumatoid arthritis; experimental induction without resort to allotype; frequent occurrence in mononucleosis.

Unlabelled: Gm system: Some RFs specifically detect Mendelian markers of human Ig, originally proving that Ig production is gene controlled. The genetic marker systems of human Ig with 17 Gm, 2 Am, 3 Km and 1 Em markers are briefly described. Examples of the usefulness of the Gm system in medicine, immunology and molecular biology are mentioned.

The effect of hemodynamically significant carotid artery disease on the hemodynamic status of the cerebral circulation.

Although the presence of a hemodynamically significant carotid artery lesion is commonly used as an indicator of impaired cerebral circulation, the effect of such lesions on cerebral perfusion pressure and cerebral blood flow has never been determined accurately. We used positron emission tomography (PET) to study 19 patients with unilateral hemodynamically significant carotid artery disease (greater than 66% diameter reduction) and no evidence of cerebral infarction. According to PET measurements in the cerebral hemisphere distal to the lesion, 7 patients had normal cerebral hemodynamics, 8 had reduced perfusion pressure with normal blood flow, and 4 had reduced blood flow.

Failure of doxycycline treatment in aquarium-associated Mycobacterium marinum infections.

Two cases of aquarium-associated Mycobacterium marinum infections are described. Neither was cured by the initial therapy consisting of surgical excision followed by doxycycline treatment. Both strains of M.

Correlation between deficiency of immunoglobulin subclass G3 and Gm allotype.

Gm allotypes were investigated in 63 Swedes: 46 females and 17 males, in whom serum IgG3 was below 0.35 g/l. Both monoclonal antibodies and polyclonal antisera were used for the quantification.

Treatment of chronic subdural hematoma by twist-drill craniotomy with continuous catheter drainage.

The case records of 114 patients were reviewed to ascertain the efficacy of bedside twist-drill craniotomy and continuous closed-system catheter drainage for the treatment of chronic subdural hematomas. Ninety-eight (86%) patients achieved an excellent outcome, and seven (6%) had no significant improvement. The total mortality from all cases was 8% in this group.

Aneurysmal bone cyst of the cervicothoracic spine: computed tomographic evaluation of the value of preoperative embolization. Case report.

In this report, the management of an aneurysmal bone cyst in the cervicothoracic region of an 8-year-old girl is described. Aneurysmal bone cyst is a histologically benign lesion that is often extremely vascular. In the spine, it can cause extensive bone destruction and compress neural structures.

Familial occurrence of cervical cancer, stages 0-IV.

All patients hospitalized in 1982 at the Department of Gynecology in Malmö because of malignancy of the cervix uteri attended an interview study concerning the presence of cervical cancer among their nearest relatives. In addition, these patients were questioned concerning earlier gonorrheal infection. The blood group was determined as also was the secretory status and Gm allotype.

Burkitt lymphoma and genetic markers of immunoglobulin.

The Ig allotype G3m (c3) was numerically more frequent among 70 Kenyan Burkitt lymphoma (BL) cases than in 70 Kenyans with other tumors of the neck (0.02 greater than p greater than 0.01).

Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans.

This study was undertaken to determine the minimum CBF and CMRO2 required by the human brain to maintain normal function and viability for more than a few hours. Positron emission tomography (PET) was used to perform regional measurements in 50 subjects with varying degrees of cerebral ischemia but no evidence of infarction. There were 24 normal subjects, 24 subjects with arteriographic evidence of vascular disease of the carotid system, and two subjects with reversible ischemic neurological deficits due to cerebral vasospasm.

Muteness of cerebellar origin.

Acute bilateral damage to large areas of both cerebellar hemispheres including the dentate nuclei led to temporary loss of speech in six children. In each case muteness was unassociated with motor paralysis, loss of higher cognitive functions, or cranial nerve dysfunction. Muteness lasted one to three months.

Gm allotypes in IgA deficiency.

Gm phenotypes were examined in 90 Swedish IgA-deficient (less than 0.05 g/litre of serum IgA) donors and 40 normal first and second degree relatives of six of these donors. The G1m1,2, G3m5 and Km1 frequency in the group of IgA-deficient donors did not differ from that found in the normal population.

Regional cerebral blood flow and metabolism in reversible ischemia due to vasospasm. Determination by positron emission tomography.

Regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of oxygen (rCMRO2) were measured by positron emission tomography (PET) in four patients with subarachnoid hemorrhage and hemiparesis due to cerebral vasospasm. With resolution of the vasospasm, two patients recovered and two remained hemiparetic. Contralateral to the hemiparesis, rCBF was slightly higher in the two patients who eventually recovered (15.

Anti-immunoglobulins in experimental streptococcal immunization; relation to bacterial growth conditions and Fc-receptors.

Heat-killed group A streptococci of types M12 and M22 were used for intravenous immunization of 60 rabbits. Presence of Fc-receptors binding monomeric IgG in M22 and their absence in M12 has been demonstrated previously. The strains were cultured in either Todd-Hewitt broth supplemented with 10% horse serum (TH-H) or in IsoVitaleX, a synthetic medium, supplemented with 10% autologous rabbit serum (IV-R).

Gm allotypes in Finnish myasthenia gravis patients.

Gm phenotype G1m 1,2, and 3 frequencies were examined in 103 Finnish myasthenia gravis patients. There were no significant differences as compared with the expected frequency, either in the total material or when patients were subdivided according to sex, age of onset of disease, thymus pathology, or presence of HLA-B8. However, individuals with Gm(+1) had a significantly higher concentration of antibodies against acetylcholine receptor, possibly indicating a correlation with severity of disease.

Physiological responses to focal cerebral ischemia in humans.

Positron emission tomography (PET) was used to investigate the regional hemodynamic and metabolic changes that accompany focal reductions in cerebral blood flow to ischemic but uninfarcted regions of the brain. Studies were performed on 7 patients chosen from a larger group of subjects with transient ischemic attacks and normal computed tomographic findings, specifically because their PET studies showed decreased blood flow to the symptomatic hemisphere rather than symmetrical flow to the two hemispheres. In regions with decreased blood flow, the cerebral metabolic rate for oxygen was also decreased, but to a lesser degree.

Extracranial-intracranial bypass surgery: hemodynamic and metabolic effects.

After superficial temporal artery-middle cerebral artery bypass, cerebral blood flow (CBF) in the operated hemisphere increased in 6 of 17 patients. Preoperatively, the symptomatic hemisphere showed lower CBF in all six, lower oxygen metabolism in five, higher blood volume in four, and higher oxygen extraction in two. With the postoperative increase in hemispheric CBF, there was a decrease in oxygen extraction, but no change in blood volume or oxygen metabolism.