Publications by authors named "Gros A"

Objective: Analyzing in a cross-sectional study the factors associated with mental health in 1511 recently delivered women returning to work, the mediating role of work-family interface, and the moderating role of social supports.

Methods: Data were collected at 3 months after returning to work to assess work characteristics (Copenhagen Psychosocial Questionnaire), work-family conflict (Survey Work-Home Interaction Nijmegen), anxiodepressive symptoms (Hospital Anxiety and Depression Scale), commuting, childcare, household demands, and social supports.

Results: Anxiety and, to a lesser extent, depressive symptoms were associated with work factors, the opposite for the nonwork demands.

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Background: "CARE" is an electronic health (e-health) application (app) which assesses frailty with its frailty module and risk of falls with its mobility module. This study examines and compares the risk of incident falls (i.e.

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Background: The reconstruction of the thumb's pulp is challenging when considering that there is no consensus on which local flap will provide better prognosis and less financial impact. The aim of this study was to analyze the outcomes of the most used flaps for the trauma to the volar substance of the thumb, validating the main indications.

Methods: This systematic review adhered to PRISMA guidelines and electronic searches were conducted in multiple databases (MEDLINE/PubMed, Virtual Health Library, Embase and Scopus) with studies published in the last ten years - until April 2022.

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Article Synopsis
  • The SWI/SNF complex is made up of proteins that help control how our DNA is organized, and mutations in these proteins can cause dangerous cancers in young people.
  • These aggressive cancers, like rhabdoid tumors and epithelioid sarcoma, are hard to treat and often do not have good outcomes for patients.
  • A study called TILTS is testing a new treatment that uses special immune cells from the patients (called TILs) that can spot and attack these tumors, making it an exciting area of research for better therapies.
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LoRa enables long-range communication for Internet of Things (IoT) devices, especially those with limited resources and low power requirements. Consequently, LoRa has emerged as a popular choice for numerous IoT applications. However, the security of LoRa devices is one of the major concerns that requires attention.

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Cognitive impairments have been reported in astronauts during spaceflights and documented in ground-based models of simulated microgravity (SMG) in animals. However, the neuronal causes of these behavioral effects remain largely unknown. We explored whether adult neurogenesis, known to be a crucial plasticity mechanism supporting memory processes, is altered by SMG.

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  • Some patients with metastatic melanoma (a type of skin cancer) don't get better from usual treatments. Scientists are looking at personalized medicine, which means tailoring treatment to the patient’s specific cancer.
  • In a study, 26 patients who found specific genetic changes in their cancer received personalized treatments, with some seeing good results.
  • The study showed that using advanced testing followed by targeted therapy might help patients whose melanoma didn't respond to regular treatments.
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Introduction: Remote digital assessments (RDAs) such as voice recording, video and motor sensors, olfactory, hearing, and vision screenings are now starting to be employed to complement classical biomarker and clinical evidence to identify patients in the early AD stages. Choosing which RDA can be proposed to individual patients is not trivial and often time-consuming. This position paper presents a decision-making algorithm for using RDA during teleconsultations in memory clinic settings.

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Background: Anosmia was one of the main symptoms of coronavirus disease 2019 (COVID-19). A psychiatric history ( depression) may be an independent contributor to the risk of COVID-19 diagnosis, and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae (bidirectional association).

Aim: To compare the rate of psychiatric disorder among post-COVID patients without anosmia patients with persistent olfactory complaints.

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Pulmonary embolism is a common complication after intracranial hemorrhage. As thrombolysis is contraindicated in this situation, surgical pulmonary embolectomy may be indicated in case of high-risk pulmonary embolism but requires transient anticoagulation with heparin during cardiopulmonary bypass. We report the case of a patient with a history of heparin-induced thrombocytopenia who presented with a high-risk pulmonary embolism 10 days after the spontaneous onset of a voluminous intracerebral hematoma.

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  • Scientists studied how platelets (tiny blood cells) interact with different types of tumors.
  • They looked at two tumors: one from breast cancer (AT-3) and one from skin cancer (B16F1).
  • They found that platelets are important in both tumors but work differently depending on the type of cancer.
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We present a spatial testbed of simulated boundary data based on a set of very high-resolution census-based areal units surrounding Guadalajara, Mexico. From these input areal units, we simulated 10 levels of spatial resolutions, ranging from levels with 5,515-52,388 units and 100 simulated zonal configurations for each level - totalling 1,000 simulated sets of areal units. These data facilitate interrogating various realizations of the data and the effects of the spatial coarseness and zonal configurations, the Modifiable Areal Unit Problem (MAUP), on applications such as model training, model prediction, disaggregation, and aggregation processes.

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Introduction: Previous studies have shown benefits of productive art-activity on frail older adults' mental and physical health. In this study, we investigated the effects of art-producing activities in a hybrid format (in-person and online) in a context of lockdown compared with previous studies taking place in museums and their effects on wellbeing, quality of life, physical frailty, and apathy in older adults.

Methods: We conducted a randomized unicentric control trial on a sample of 126 seniors older than 65 years (mean age 71.

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Background And Objective: Olfactory disorders in COVID-19 impact quality of life and may lead to psychological impairments. Prevalence ranges from 8 to 85%, persisting in about 30% of cases. This study aimed to evaluate the 6-month post-COVID-19 impact on quality of life, hedonic experiences, anxiety and depression due to olfactory disorders.

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Background: The benefit-risk balance and optimal timing of surgery for severe infective endocarditis (IE) with ischemic or hemorrhagic strokes is unknown. The study aim was to compare the neurological outcome between patients receiving surgery or not.

Methods: In a prospective register-based multicenter ICU study, patients were included if they met the following criteria: (i) left-sided IE with an indication for heart surgery; (ii) with cerebral complications documented by cerebral imaging before cardiac surgery; (iii) with Sequential Organ Failure Assessment score ≥ 3.

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Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregulated upon induction of senescence in different types of cancer cells. PD-L2 is not required for cells to undergo senescence, but it is critical for senescent cells to evade the immune system and persist intratumorally.

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Background: Health benefits have been reported with art activities. Heart rate is a biomarker of health state. The aim of this randomized controlled trial (RCT) was to compare the changes in heart rate over a 3 month-period in older adults participating in art-based activities at the Montreal Museum of Fine Arts (MMFA, Quebec, Canada) and in their control counterparts.

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Article Synopsis
  • Uveal melanoma (UM) is the most common eye cancer in adults, with most patients carrying specific gene mutations (GNAQ/GNA11 Q209L/Q209P).
  • Researchers believe these mutations can be recognized by the immune system, even in the immune-suppressed environment of the eye.
  • Analysis of tumor data shows that Q209L is more likely to trigger an immune response than Q209P, suggesting potential for new treatments, such as vaccines targeting this mutation.
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Purpose: Olfactory identification disorder is considered a promising early biomarker of Alzheimer's disease (AD). The QUICK TODA2 can be used as a short olfactory screening tool specific for French AD patients. The selection of AD specific odorants and the design of this screening were the main objectives of this twofold study.

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Introduction: The use of teleconsultations for mental health has drastically increased since 2020 due to the Covid19 pandemic. In the present paper, we aimed to analyze the advantages and disadvantages of teleconsultations for mental health compared to face-to-face consultations, and to provide recommendations in this domain.

Methods: The recommendations were gathered using a Delphi methodology.

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Background: The significant prevalence of children with high intellectual potential (HIP) in the school-age population and the high rate of comorbidity with learning disabilities such as dyslexia has increased the demand for speech and language therapy and made it more complex. However, the management of dyslexic patients with high intellectual potential (HIP-DD) is poorly referenced in the literature. A large majority of studies on HIP-DD children focus on the screening and diagnosis of developmental dyslexia, but only a few address remediation.

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Objective: This study investigates the possibility of adopting motor and cognitive dual-task (MCDT) approaches to identify subjects with mild cognitive impairment (MCI) and subjective cognitive impairment (SCI).

Methods: The upper and lower motor performances of 44 older adults were assessed using the SensHand and SensFoot wearable system during three MCDTs: forefinger tapping (FTAP), toe-tapping heel pin (TTHP), and walking 10 m (GAIT). We developed five pooled indices (PIs) based on these MCDTs, and we included them, along with demographic data (age) and clinical scores (Frontal Assessment Battery (FAB) scores), in five logistic regression models.

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Glioblastoma (GBM) contains cancer stem cells (CSC) that are resistant to treatment. GBM CSC expresses glycolipids recognized by the A2B5 antibody. A2B5, induced by the enzyme ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyl transferase 3 (ST8Sia3), plays a crucial role in the proliferation, migration, clonogenicity and tumorigenesis of GBM CSC.

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Purpose: Museum-based art activities have demonstrated health benefits in older adults. Few clinical trials, however, have examined physical health benefits specifically. This randomized controlled trial (RCT) aims to compare changes in daily step count over a 3-month period in older adults participating in museum-based art activities and their control counterparts.

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