[The course and outcome of viral hepatitis B in drug-addicted patients].

In this paper, characterization is given of clinical and biochemical features of VH B course against the background of narcomania. Recordable in such patient populations are high percentage of delta hepatitis (14.2%), unusual severity of the intoxication syndrome, protracted course with exacerbations (12.

[The diagnostic significance of lipoprotein-X].

Lipoproteid-X was revealed at the onset of the disease in 59.6% of patients with acute viral hepatitis with prevalence of the cholestasis syndrome and cytolysis. Lipoproteid-X may be revealed in moderate activity of alkaline phosphatase.

[Excretion of bile acids in feces in pathology of the liver and intestines].

Intestinal excretion of free bile acids (BA), i.e. of cholic, chenodeoxycholic, deoxycholic, lithocholic, and of conjugated BA, i.

[Isoenzymes of blood serum alkaline phosphatase under experimental cholemia].

The activity and isoenzymic spectrum of alkaline phosphatase of the blood serum and liver under cholemia caused by deoxycholic acid were compared in healthy animals and in animals with the affected liver. It is shown, that under conditions of the bile acids higher content in the organism due to deoxycholic acid, the total activity increases considerably and there appears an isoenzyme absent in the blood serum of healthy animals. Changes in the activity and isoenzymic spectrum of alkaline phosphatase under experimental cholemia developing against a background of the healthy and affected liver are characterized by certain peculiarities.

[Serum alkaline phosphatase isoenzymes in rats at different periods after bile duct transection].

Total activity and isoenzymic spectrum of the blood serum and liver alkaline phosphatase were studied with experimental obstructive jaundice beginning from the first hours of its development till 30 days. Changes in the activity of alkaline phosphatase and its isoenzymic spectrum are shown to have their characteristic features at different times of obstructive jaundice.

[Enzyme activity during regeneration under acute and chronic liver lesion with CCL4].

Activity of alanine and aspartate aminotransferase, alkaline phosphatase, adenosine, desaminase and AMP-aminohydrolase was determined in rats in the process of the liver regeneration under acute and chronic lesion with CCl4. It is shown that under chronic lesion of the liver with CCl4, in contrast to the acute one, changes in the aminotransferase activity in blood serum are not expressed in the liver, the activity is essentially decreased. A steady increase was observed in the activity of adenosine desaminase, AMP-aminohydrolase and alkaline phosphatase in the liver and blood serum.