[Efficacy of Pygeum africanum extract in the medical therapy of urination disorders due to benign prostatic hyperplasia: evaluation of objective and subjective parameters. A placebo-controlled double-blind multicenter study].

The efficacy of an extract of Pygeum africanum in the treatment of micturitional disorders due to benign prostatic hyperplasia was tested in a multicentre double-blind trial versus placebo. Capsules containing 50 mg of Pygeum africanum extract or placebo were administered at a dosage of 1 capsule in the morning and 1 capsule in the evening over a period of 60 days. 263 patients were included in this study, which was carried out in 8 centres in Germany, France, and Austria.

[Long-term intravesical treatment with adriamycin in chemoprevention of recurrence of transurethrally resected urinary bladder cancers].

64 patients with a histologically verified urothelial tumour of the urinary bladder were given intravesical Adriamycin-instillations after transurethral resection of their tumours. 34 patients received 50 mg Adriamycin once weekly for a period of 6 weeks. 30 patients, after undergoing this initial treatment, were treated with 50 mg Adriamycin once a month over a period of 2 years.

[Adjuvant topical chemotherapy with cisplatin in superficial bladder cancer].

During a period of 6 weeks we applied a weekly dosage of 50 mg of cis-platinum as an intravesical instillation treatment to 30 patients with superficial carcinomas of the urinary bladder. Prior to this treatment these patients had undergone a transurethral differentiated resection of their tumours by multiple biopsies (mapping). Persistent tumours were found in 3 patients (10%).

Prophylactic use of topical adriamycin after transurethral resection of transitional cell bladder tumours.

Thirty-five patients with carcinoma of the bladder were subjected to weekly intravesical instillation treatment with 30 mg adriamycin/50 ml solution for a period of 6 weeks following transurethral resection of the tumour. The oncolytic and thus recurrence-preventive value of treatment was determined by endoscopic controls with exploratory excisions and exfoliative cytology. All in all, a recurrence-free rate was found in 77% over a minimum observation period of one year.

[Prevention of recurrence in urinary bladder tumors by intravesical instillation treatment with adriamycin].

109 patients with urinary bladder cancer received post TUR treatment with weekly intravesical instillations of Adriamycin for a period of 6 weeks. 32 patients received a dosage of 10 mg/50 ml physiological NaCl, 35 patients a dosage of 30 mg/50 ml physiological NaCl. We determined the oncolytical value and the value of prophylactically reduced recurrence through urine cytology and endoscopic controls with biopsies.

[Prevention of the recurrence of superficial bladder cancer].

A report is given on recidive prophylaxis in connection with 204 superficial urothelial tumours (pTa and pT1 ) of the urinary bladder. 30 patients received postoperative Betatron or Telekobalt irradiation. The relapse rate was 53%.

[Can the persistence rate of transurethrally resected bladder tumors be lowered by postoperative instillation of silver nitrate?].

In 19 out of 88 patients (22%) who had undergone transurethral resection of urothelial carcinoma of the urinary bladder persistent tumours occurred (= tumour detected locally within 3 months). Among 52 patients who had had TUR of urothelial carcinoma and postoperative silver nitrate instillation persistent tumours were found in 11 cases (21%). The persistence rate correlates to the depth of infiltration and the dedifferentiation of the primary tumour.

[Adjuvant local instillation with vitamin A in the therapy of bladder tumours following transurethral resection].

Following transurethral resection of the tumour, 58 patients with histologically verified transitional cell carcinoma were subjected to local instillation treatment and oral vitamin A therapy. The instillation were carried out once a week over a 6-week period; cystoscopy with biopsy were carried out at 3-month intervals over an average period of 2.7 years.

[Diagnosis and therapy of postoperative stricture of the posterior urethra].

A distinction is made between stenosis of the vesical cervix and a layered stricture. No aetiological parameter is certain. Besides uroflow, miction cystourethrography (MCU is of diagnostic importance.

[Adjuvant local BCG-immunotherapy in patients with urothel cancer of the bladder (author's transl)].

45 patients with urothel cancer of the bladder were examined clinically and immunologically and treated after transurethral resection with intravesical application of BCG as active unspecific immune therapy. The results of immunological cutaneous tests and the grade of peritumoral infiltration with immune competent cells were compared with histological grading and staging of the tumour. No significant relation between the results could be found.

[Catheter embolization of inoperable kidney neoplasms with the GAW-spiral].

On the basis of 4 cases with inoperable hypernephroma the possibilities of the transfemoral catheter embolisation with the GAW-spiral are discussed. Simplicity of the technique and advantages in comparison to the material embolisation methods are discussed. The case in question was in 2 patients a primary embolisation, in 2 patients a secondary one with recanalised material embolisation.

[The prune belly syndrome].

On the basis of a specific case and of references, the problems concerning the symptoms, diagnoses and the therapy of the Prune-Belly syndrome are presented. The importance of a urodynamic check-up prior to surgical measures is underlined. Due to the many combinations of malfunctions and the lack of sexual specification, it seems preferable to consider mesenchymal dysplasia as the focal point of interest rather than the abdominal muscle defecite--uromalformation--kryptorchism--triad.