Effects of various vitamins and coenzymes Q on reactions involving alpha-hydroxyl-containing radicals.

Effects of vitamins B, C, E, K and P, as well as coenzymes Q, on formation of final products of radiation-induced free-radical transformations of ethanol, ethylene glycol, alpha-methylglycoside and glucose in aqueous solutions were studied. Based on the obtained results, it can be concluded that there are substances among vitamins and coenzymes that effectively interact with alpha-hydroxyl-containing radicals. In the presence of these substances, recombination reactions of alpha-hydroxyalkyl radicals and fragmentation of alpha-hydroxy-beta-substituted organic radicals are suppressed.

[A cytomorphological basis for the correction of radiation-induced immunodeficiencies and hematopoietic depression using thymus and bone marrow peptides].

The correction of radiation-induced immunodeficiency and hematopoiesis depression in clinical setting (100 patients) and in experiments (160 animals) by peptide preparations of the thymus and bone marrow (thymalin, hemalin, thymogemine and synthetic thymalin analog thymogen) has been studied. Administration of the bone marrow and thymus recovery of damage to the thymus, bone marrow, spleen and lymph nodes, improved the function of circulating neutrophilic granulocytes. Thymalin was able to compensate for immune disturbances and reduce manifestations of asthenia.

[Morphofunctional status of the thymus in guinea pigs exposed to thymus and bone marrow preparations].

Study of the effect of the polypeptide thymic factor (thymalin) and the polypeptide bone marrow factor (hemalin) on the morphofunctional status of the thymus in guinea-pigs has shown that injection of thymalin into animals increases the count of small lymphocytes whereas injection of hemalin the count of medium-sized lymphocytes and lymphoblasts. Injection of thymalin magnifies the size of the nuclei of the reticuloendothelial cells.

[Effect of thymalin on the thymus and immunologic indices of irradiated animals].

The intramuscular injection of thymaline (1 mg/kg/day during 5 days) enhanced the regenerative processes in the thymus and favored the normalization of some immunological indices of irradiated guinea pigs.

[Morphological changes in the thymus in experimental autoimmune hemolytic anemia].

Morphological changes in the mouse thymus in the experimental autoimmune hemolytic anemia were correlated with the results of the study of the immune status. The epithelial component of the thymus was more involved in the response to the experimental autoimmune hemolytic anemia during the whole experiment; this allows one to assume that just this component predetermines the character of this autoimmune process.

[Mucoepidermoid tumor of the thymus gland].

The description of mucoepidermoid tumour of the thymus in a 14-year-old girl is given. The observation is of interest due to unusual localization and the rarity of thymic tumours in children.

[Morphofunctional state of organs of immunogenesis and adrenal glands after administration of a thymus preparation (thymaline)].

Comparative characterization of morphofunctional changes in the thymus, secondary immunogenesis organs, and adrenal cortex after 10-day subcutaneous inoculations of CBA mice with a thymus preparation, thymaline, showed enhanced thymus functioning and not very marked signs of migrational activity of lymphocytes in lymph nodes under conditions of a prolonged effect of thymaline in normal animals to run in a reduced hormonal activity of adrenocorticocytes.

[Lymphocytic thymoma developing in the wall of a thymus cyst].

Among 648 patients having undergone thymectomy for myasthenia, the authors observed one female in which the operation revealed a multilobular cyst of the thymus. The features of the histological structure of the cyst undoubtedly indicate its primary nature. A detailed microscopic examination of the fibrous cyst wall revealed some elements of the tumor growth having the structure of lymphocytic thymoma.

[Unique microscopic picture of the thymus gland in myasthenic thymoma].

In the course of microscopic examination of 535 thymuses excized from patients with myasthenia (among them 60 with thymoma) the authors came across only one case in which there were numerous large foreign bodies granulomas in the thymus. Despite such a polymorphous structure of the thymus, the clinical course of the underlying disease did not show any specific features.

[Effect of progesterone and estrogens on the state of the hypothalamo-hypophyseal neurosecretory system in pregnancy and labor].

Morphofunctional state of the hypothalamo-hypophyseal neurosecretory system was studied in rats at late stages of pregnancy. No special differences both in function of the supraoptical and praventricular nuclei, and in the hypophysis of intact and pregnant rats at administration of progesterone were noted. When estrogenes were administered to pregnant animals, a sharp increase in functioning of the supraoptic and especially of the paraventricular nuclei was noted.

[Effect of polypeptides isolated from the anterior hypothalamus and epiphysia on cells of the hypothalamo-hypophyseal neurosecretory system].

A comparative study on the influence of physiologically active substances, extracted from the epiphysis and the anterior hypophalamus, on the morpho-functional status of the cells of the hypophalamo hypophysial neurosecretory system was carried out. The substances in question were extracted from the cattie epiphysis and anterior hypothalamus by means of acetic acid extraction from acetone-dehydrated tissue and the following sedimentation of the substances by means of cooled acetone and lyophilization. The investigation of the substances demonstrated them to be polypeptides with an average molecular weights from 2.