Collagen-Binding Peptide-Enabled Supramolecular Hydrogel Design for Improved Organ Adhesion and Sprayable Therapeutic Delivery.

Spraying serves as an attractive, minimally invasive means of administering hydrogels for localized delivery, particularly due to high-throughput deposition of therapeutic depots over an entire target site of uneven surfaces. However, it remains a great challenge to design systems capable of rapid gelation after shear-thinning during spraying and adhering to coated tissues in wet, physiological environments. We report here on the use of a collagen-binding peptide to enable a supramolecular design of a biocompatible, bioadhesive, and sprayable hydrogel for sustained release of therapeutics.

Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases.

Respiratory illnesses are prevalent around the world, and inhalation-based therapies provide an attractive, noninvasive means of directly delivering therapeutic agents to their site of action to improve treatment efficacy and limit adverse systemic side effects. Recent trends in medicine and nanoscience have prompted the development of inhalable nanomedicines to further enhance effectiveness, patient compliance, and quality of life for people suffering from lung cancer, chronic pulmonary diseases, and tuberculosis. Herein, we discuss recent advancements in the development of inhalable nanomaterial-based drug delivery systems and analyze several representative systems to illustrate their key design principles that can translate to improved therapeutic efficacy for prevalent respiratory diseases.

A Thematic Analysis of the Impact of as a Tool for Sexual Violence Prevention.

The purpose of this study is to explore the impact of an educational documentary, (), as a sexual violence prevention tool. is a short (i.e.

Adsorption of Sulfamethazine from Environmentally Relevant Aqueous Matrices onto Hypercrosslinked Adsorbent MN250.

Four hundred tons of sulfamethazine are fed to livestock annually in North America for disease prevention and growth promotion, but the majority is excreted unmetabolized into the environment. Due to its slow degradation and high mobility, sulfamethazine contaminates groundwater and causes aquatic ecosystem damage. Sulfamethazine remediation methods are not universally effective, necessitating newer techniques.

Removal of sulfamethazine by hypercrosslinked adsorbents in aquatic systems.

Four hundred tons of sulfamethazine are fed to livestock annually in North America to prevent disease and promote growth, but most of the drug is excreted unmetabolized into the environment. Because of slow degradation and high mobility, sulfamethazine contaminates groundwater supplies and causes aquatic ecosystem damage. Current water treatment methods to remove pharmaceuticals are not universally effective and have considerable limitations, which necessitate newer remediation techniques.

A method for determination of selenium in organic tissues using microwave digestion and liquid chromatography.

An existing laboratory procedure for selenium analysis using open-vessel wet digestion and liquid chromatographic fluorescence determination was modified for use with microwave digestion. The proposed microwave digestion method eliminated the hazards associated with the use of HClO4 while maintaining excellent recoveries of selenium. A 2-step HNO3/H2O2 digestion procedure was developed.

Compost, manure, and gypsum application to timothy/red clover forage.

Some of the most fertile agricultural land in Atlantic Canada includes dykelands, which were developed from rich salt marshes along the Bay of Fundy through the construction of dykes. A 2-yr field experiment was conducted on dykeland soil to evaluate the effect of fertility treatments: source-separated municipal solid waste (SS-MSW) compost, solid manure, commercial fertilizer, and gypsum on (1) timothy/red clover forage productivity, (2) N, S, and other nutrients uptake, and (3) residual NO(3)-N and NH(4)-N in the soil profile. All fertility treatments increased dry matter yields from the two cuts each year relative to the control.

Radial keratotomy clear zone diameter errors.

Purpose: To examine the variability of achieved clear zone diameters following radial keratotomy and to determine if refractive outcomes are correlated to clear zone diameter errors.

Methods: Twenty-six patients with radial keratotomy (51 eyes) were studied retrospectively. The central clear zone diameter for each radial incision meridian was measured using a slit-lamp and a photograph.

The call of the sirens: ethically navigating the sea of nonvalidated therapies.

Medical research and innovation are vital to the advancement of medicine and, ultimately, benefit society and individual patients. However, the ethical principles of beneficence, respect for persons, and justice must guide the development and implementation of new practices. Ethical codes governing clinical practice and research already warn practitioners to avoid the use of nonvalidated practices outside of controlled clinical trials.

Measurement of radial keratotomy clear zone diameters.

Background: To compare the accuracy of photographic measurements to slit-lamp measurements of radial keratotomy clear zone diameters in order to develop an independent, objective, unbiased, and reproducible method of verifying clinical observations.

Methods: Twenty-five patients (48 eyes) following radial keratotomy had matched slit-lamp and photographic measurements of the diameter of the central clear cornea between the ends of opposite radial incision pairs. Matched slit-beam, photographic, and pathologic observations were compared statistically.

Complications of small clear-zone radial keratotomy.

Purpose: To review the postoperative outcome of patients with radial keratotomy who have clear-zone diameters below 2.75 mm.

Methods: A retrospective review was performed of all patients with radial keratotomy who have clear-zone diameters less than 2.

Superior rectus muscle overaction after cataract extraction.

Four patients with an ipsilateral hypertropia after cataract extraction consistent with superior rectus muscle overaction were identified between March 1990 and April 1992. Operative trauma was the most likely causative factor, as other likely conditions were excluded. The proposed pathogenesis for all cases is similar to that of botulinum type-A toxin therapy: a transient postoperative weakness of the ipsilateral inferior rectur muscle leads to a contracture or strengthening of the ipsilateral antagonist (the superior rectus muscle).