Comparison Evaluation of Automated Nucleated Red Blood Cell Enumeration by Sysmex XN 1000 in Comparison With Microscopic Reference in Children Under 1 Year.

Background: In newborns, elevated nucleated red blood cell (NRBC) levels can be associated with enhanced erythropoietic stress and might be predictive for adverse outcome. Also, the presence of NRBC in peripheral blood might lead to erroneous enumeration results of white blood cells in automated hematology analyzers. We aimed to assess the comparability of the Sysmex XN 1000 to manual slide reviews and correlation of NRBC with inflammation markers.

Impact of Vaccination on the Course and Outcome of COVID-19 in Patients with Multimorbidity.

Vaccination is the most cost-effective method of preventing COVID-19; however, data on its effect on patients with multimorbidity is limited. The aim was to evaluate the effect of vaccination against new coronavirus infection (NCI) in patients with multimorbid pathology in hospital treatment on the outcome of COVID-19 disease. An analysis was carried out of 1832 records of patients in one of the COVID-19 hospitals in Moscow for 2020-2022.

Methodological considerations for estimating policy effects in the context of co-occurring policies.

Understanding how best to estimate state-level policy effects is important, and several unanswered questions remain, particularly about the ability of statistical models to disentangle the effects of concurrently enacted policies. In practice, many policy evaluation studies do not attempt to control for effects of co-occurring policies, and this issue has not received extensive attention in the methodological literature to date. In this study, we utilized Monte Carlo simulations to assess the impact of co-occurring policies on the performance of commonly-used statistical models in state policy evaluations.

Niche evolution in a northern temperate tree lineage: biogeographical legacies in cork oaks (Quercus section Cerris).

Background And Aims: Cork oaks (Quercus section Cerris) comprise 15 extant species in Eurasia. Despite being a small clade, they display a range of leaf morphologies comparable to the largest sections (>100 spp.) in Quercus.

Open community platform for hearing aid algorithm research: open Master Hearing Aid (openMHA).

(openMHA) was developed and provided to the hearing aid research community as an open-source software platform with the aim to support sustainable and reproducible research towards improvement and new types of assistive hearing systems not limited by proprietary software. The software offers a flexible framework that allows the users to conduct hearing aid research using tools and a number of signal processing plugins provided with the software as well as the implementation of own methods. The openMHA software is independent of a specific hardware and supports Linux, macOS and Windows operating systems as well as 32-bit and 64-bit ARM-based architectures such as used in small portable integrated systems.

Self-motion with Hearing Impairment and (Directional) Hearing Aids.

When listening to a sound source in everyday situations, typical movement behavior is highly individual and may not result in the listener directly facing the sound source. Behavioral differences can affect the performance of directional algorithms in hearing aids, as was shown in previous work by using head movement trajectories of normal-hearing (NH) listeners in acoustic simulations for noise-suppression performance predictions. However, the movement behavior of hearing-impaired (HI) listeners with or without hearing aids may differ, and hearing-aid users might adapt their self-motion to improve the performance of directional algorithms.

Amniotic Epithelial Stem Cells Counteract Acidic Degradation By-Products of Electrospun PLGA Scaffold by Improving Their Immunomodulatory Profile In Vitro.

Electrospun poly(lactic--glycolic acid) (PLGA) scaffolds with highly aligned fibers (ha-PLGA) represent promising materials in the field of tendon tissue engineering (TE) due to their characteristics in mimicking fibrous extracellular matrix (ECM) of tendon native tissue. Among these properties, scaffold biodegradability must be controlled allowing its replacement by a neo-formed native tendon tissue in a controlled manner. In this study, ha-PLGA were subjected to hydrolytic degradation up to 20 weeks, under di-HO and PBS conditions according to ISO 10993-13:2010.

5S-IGS rDNA in wind-pollinated trees (Fagus L.) encapsulates 55 million years of reticulate evolution and hybrid origins of modern species.

Standard models of plant speciation assume strictly dichotomous genealogies in which a species, the ancestor, is replaced by two offspring species. The reality in wind-pollinated trees with long evolutionary histories is more complex: species evolve from other species through isolation when genetic drift exceeds gene flow; lineage mixing can give rise to new species (hybrid taxa such as nothospecies and allopolyploids). The multi-copy, potentially multi-locus 5S rDNA is one of few gene regions conserving signal from dichotomous and reticulate evolutionary processes down to the level of intra-genomic recombination.

Development and evaluation of video recordings for the OLSA matrix sentence test.

Objective: The aim was to create and validate an audiovisual version of the German matrix sentence test (MST), which uses the existing audio-only speech material.

Design: Video recordings were recorded and dubbed with the audio of the existing German MST. The current study evaluates the MST in conditions including audio and visual modalities, speech in quiet and noise, and open and closed-set response formats.

Review of Self-Motion in the Context of Hearing and Hearing Device Research.

The benefit from directional hearing devices predicted in the lab often differs from reported user experience, suggesting that laboratory findings lack ecological validity. This difference may be partly caused by differences in self-motion between the lab and real-life environments. This literature review aims to provide an overview of the methods used to measure and quantify self-motion, the test environments, and the measurement paradigms.

The Virtual Reality Lab: Realization and Application of Virtual Sound Environments.

To assess perception with and performance of modern and future hearing devices with advanced adaptive signal processing capabilities, novel evaluation methods are required that go beyond already established methods. These novel methods will simulate to a certain extent the complexity and variability of acoustic conditions and acoustic communication styles in real life. This article discusses the current state and the perspectives of virtual reality technology use in the lab for designing complex audiovisual communication environments for hearing assessment and hearing device design and evaluation.

The Quest for Ecological Validity in Hearing Science: What It Is, Why It Matters, and How to Advance It.

Ecological validity is a relatively new concept in hearing science. It has been cited as relevant with increasing frequency in publications over the past 20 years, but without any formal conceptual basis or clear motive. The sixth Eriksholm Workshop was convened to develop a deeper understanding of the concept for the purpose of applying it in hearing research in a consistent and productive manner.

Phylogenetic relationships in the southern African genus (Ruschioideae, Aizoaceae).

Background: , the only genus of the tribe Drosanthemeae, is widespread over the Greater Cape Floristic Region in southern Africa. With 114 recognized species, together with the highly succulent and species-rich tribe Ruschieae, constitute the 'core ruschioids' in Aizoaceae. Within , nine subgenera have been described based on flower and fruit morphology.

Evaluation of the Influence of Head Movement on Hearing Aid Algorithm Performance Using Acoustic Simulations.

Head movements can improve sound localization performance and speech intelligibility in acoustic environments with spatially distributed sources. However, they can affect the performance of hearing aid algorithms, when adaptive algorithms have to adjust to changes in the acoustic scene caused by head movement (the so-called maladaptation effect) or when directional algorithms are not facing in the optimal direction because the head has moved away (the so-called misalignment effect). In this article, we investigated the mechanisms behind these maladaptation and misalignment effects for a set of six standard hearing aid algorithms using acoustic simulations based on premade databases; this was done so we could study the effects as carefully as possible.

Evolutionary dynamics in the dispersal of sign languages.

The evolution of spoken languages has been studied since the mid-nineteenth century using traditional historical comparative methods and, more recently, computational phylogenetic methods. By contrast, evolutionary processes resulting in the diversity of contemporary sign languages (SLs) have received much less attention, and scholars have been largely unsuccessful in grouping SLs into monophyletic language families using traditional methods. To date, no published studies have attempted to use language data to infer relationships among SLs on a large scale.

Genomic landscape of the global oak phylogeny.

The tree of life is highly reticulate, with the history of population divergence emerging from populations of gene phylogenies that reflect histories of introgression, lineage sorting and divergence. In this study, we investigate global patterns of oak diversity and test the hypothesis that there are regions of the oak genome that are broadly informative about phylogeny. We utilize fossil data and restriction-site associated DNA sequencing (RAD-seq) for 632 individuals representing nearly 250 Quercus species to infer a time-calibrated phylogeny of the world's oaks.

Movement and Gaze Behavior in Virtual Audiovisual Listening Environments Resembling Everyday Life.

Recent achievements in hearing aid development, such as visually guided hearing aids, make it increasingly important to study movement behavior in everyday situations in order to develop test methods and evaluate hearing aid performance. In this work, audiovisual virtual environments (VEs) were designed for communication conditions in a living room, a lecture hall, a cafeteria, a train station, and a street environment. Movement behavior (head movement, gaze direction, and torso rotation) and electroencephalography signals were measured in these VEs in the laboratory for 22 younger normal-hearing participants and 19 older normal-hearing participants.

Effects of directional hearing aid settings on different laboratory measures of spatial awareness perception.

Hearing loss can negatively influence the spatial hearing abilities of hearing-impaired listeners, not only in static but also in dynamic auditory environments. Therefore, ways of addressing these deficits with advanced hearing aid algorithms need to be investigated. In a previous study based on virtual acoustics and a computer simulation of different bilateral hearing aid fittings, we investigated auditory source movement detectability in older hearing- impaired (OHI) listeners.

Plant fossils reveal major biomes occupied by the late Miocene Old-World Pikermian fauna.

Reconstruction of palaeobiomes, ancient communities that exhibit a physiognomic and functional structure controlled by their environment, depends on proxies from different disciplines. Based on terrestrial mammal fossils, the late Miocene vegetation from China to the eastern Mediterranean and East Africa has been reconstructed as a single cohesive biome with increasingly arid conditions, with modern African savannahs the surviving remnant. Here, we test this reconstruction using plant fossils spanning 14-4 million years ago from sites in Greece, Bulgaria, Turkey, the Tian Shan Mountains and Baode County in China, and East Africa.

Comparative systematics and phylogeography of Section in western Eurasia: inferences from plastid and nuclear DNA variation.

Oaks () comprise more than 400 species worldwide and centres of diversity for most sections lie in the Americas and East/Southeast Asia. The only exception is the Eurasian sect. that comprises about 15 species, most of which are confined to western Eurasia.

Indications for and outcome in patients with the wearable cardioverter-defibrillator in a nurse-based training programme: results of the Austrian WCD Registry.

Background: The wearable cardioverter-defibrillator is a treatment option for patients at temporarily high risk of sudden cardiac death or in whom implantation of a cardioverter-defibrillator is temporarily not possible.

Objectives: The aim of this study was to provide real-world data on patients receiving this therapy in a nurse-based wearable cardioverter-defibrillator training programme.

Methods: A registry including all patients prescribed with a wearable cardioverter-defibrillator in Austria between 2010 and 2016.

A Comparison of Strategies for Recruiting Teachers Into Survey Panels.

We examine a range of options for recruiting teachers into a nationally representative survey panel. Recruitment strategies considered include a telephone-based approach and the use of promised incentives and pre-incentives of varying amounts and forms. Using a randomized experiment, we evaluate the effectiveness of five separate recruitment strategies and conduct a cost-benefit analysis.