This study evaluated the effectiveness of 18 F-fludarabine (18 F-FLUDA) PET/CT in distinguishing between primary central nervous system lymphomas (PCNSLs) and glioblastoma multiformes (GBMs).
Researchers examined patients with either untreated PCNSL, PCNSL treated with corticosteroids, or GBM, using MRI and two PET tracers (11 C-MET and 18 F-FLUDA).
Results indicated that 18 F-FLUDA showed significant differences in uptake patterns between PCNSL and GBM, with specific parameters achieving 100% sensitivity and specificity, suggesting 18 F-FLUDA could be a valuable tool for diagnosis, despite potential interference from corticost
Introduction: Germinogenic central nervous system (CNS) tumors represent a heterogeneous group of tumors, constituting approximately 0.4% of all primary brain tumors. Removal of the tumor has no prognostic value.