Measurement of the 2νββ Decay Rate and Spectral Shape of ^{100}Mo from the CUPID-Mo Experiment.

Neutrinoless double beta decay (0νββ) is a yet unobserved nuclear process that would demonstrate Lepton number violation, a clear evidence of beyond standard model physics. The process two neutrino double beta decay (2νββ) is allowed by the standard model and has been measured in numerous experiments. In this Letter, we report a measurement of 2νββ decay half-life of ^{100}Mo to the ground state of ^{100}Ru of [7.

LiMoO Scintillating Bolometers for Rare-Event Search Experiments.

We report on the development of scintillating bolometers based on lithium molybdate crystals that contain molybdenum that has depleted into the double-β active isotope 100Mo (Li2100deplMoO4). We used two Li2100deplMoO4 cubic samples, each of which consisted of 45-millimeter sides and had a mass of 0.28 kg; these samples were produced following the purification and crystallization protocols developed for double-β search experiments with 100Mo-enriched Li2MoO4 crystals.

Single crystals of undoped LiWO and LiWMoO: formation enthalpies, heat capacity in the temperature range 320-997 K.

The LiWO single crystal was first grown by applying the Czochralski technique with weight control and low-temperature-gradients. A single crystal of LiWO is one of the perspective materials for researching rare events. The heat capacity for a LiWMoO single crystal has been determined by DSC calorimetry in the temperature range 320-997 K for the first time.

New Limit for Neutrinoless Double-Beta Decay of ^{100}Mo from the CUPID-Mo Experiment.

The CUPID-Mo experiment at the Laboratoire Souterrain de Modane (France) is a demonstrator for CUPID, the next-generation ton-scale bolometric 0νββ experiment. It consists of a 4.2 kg array of 20 enriched Li_{2}^{100}MoO_{4} scintillating bolometers to search for the lepton-number-violating process of 0νββ decay in ^{100}Mo.

[Comparative analysis of Kameton spraying parameters of different manufacturers].

Purpose: Based on a comparative analysis of the key dispersion parametries of spray-aerosol forms of drugs Kameton from different manufacturers the most effective drug in terms of delivery to the mucous membrane of the throat was choosen.

Material And Methods: The objects of study were 5 drugs brand Kameton, produced in the form of a metered-dose spray manufacturers of 'Firm 'VIPSMED' (RF), 'Altayvitaminy' (RF), 'Samaramedprom' (RF), 'ESCO-Pharm' (Armenia) and metered-dose aerosol - of 'Pharmstandard' (RF). Measurement of the dynamic characteristics of the spray and the dispersed composition of the spray was carried out by the method of shadow photography with digital image processing using the 'POLIS' system.

Development of DNA Aptamers to Native EpCAM for Isolation of Lung Circulating Tumor Cells from Human Blood.

We selected DNA aptamers to the epithelial cell adhesion molecule (EpCAM) expressed on primary lung cancer cells isolated from the tumors of patients with non-small cell lung cancer using competitive displacement of aptamers from EpCAM by a corresponding antibody. The resulting aptamers clones showed good nanomolar affinity to EpCAM-positive lung cancer cells. Confocal microscopy imaging and spectral profiling of lung cancer tissues confirmed the same protein target for the aptamers and anti-EpCAM antibodies.

Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field.

Biomedical applications of magnetic nanoparticles under the influence of a magnetic field have been proved useful beyond expectations in cancer therapy. Magnetic nanoparticles are effective heat mediators, drug nanocarriers, and contrast agents; various strategies have been suggested to selectively target tumor cancer cells. Our study presents magnetodynamic nanotherapy using DNA aptamer-functionalized 50 nm gold-coated magnetic nanoparticles exposed to a low frequency alternating magnetic field for selective elimination of tumor cells .

DNA Aptamers for the Characterization of Histological Structure of Lung Adenocarcinoma.

Nucleic acid aptamers are becoming popular as molecular probes for identification and imaging pathology and, at the same time, as a convenient platform for targeted therapy. Recent studies have shown that aptamers may be effectively used for tumor characterization and as commercially available monoclonal antibodies. Here we present three DNA aptamers binding to whole transformed lung cancer tissues, including tumor cells, connective tissues, and blood vessels.

Development of -containing scintillating bolometers for a high-sensitivity neutrinoless double-beta decay search.

This paper reports on the development of a technology involving -enriched scintillating bolometers, compatible with the goals of CUPID, a proposed next-generation bolometric experiment to search for neutrinoless double-beta decay. Large mass ( ), high optical quality, radiopure -containing zinc and lithium molybdate crystals have been produced and used to develop high performance single detector modules based on 0.2-0.

Noninvasive Microsurgery Using Aptamer-Functionalized Magnetic Microdisks for Tumor Cell Eradication.

Magnetomechanical cell disruption using nano- and microsized structures is a promising biomedical technology used for noninvasive elimination of diseased cells. It applies alternating magnetic field (AMF) for ferromagnetic microdisks making them oscillate and causing cell membrane disruption with cell death followed by apoptosis. In this study, we functionalized the magnetic microdisks with cell-binding DNA aptamers and guided the microdisks to recognize cancerous cells in a mouse tumor in vivo.

[Clinical characteristics of pain syndrome in patients with multiple myeloma].

Aim: To study pain syndrome characteristics in the trunk and extremities of patients with multiple myeloma (MM).

Material And Methods: The study involved 120 patients with MM, aged from 34 to 83 years. The duration of disease was 2-37 months.

Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human Blood.

Circulating tumor cells (CTCs) are rare cells and valuable clinical markers of prognosis of metastasis formation and prediction of patient survival. Most CTC analyses are based on the antibody-based detection of a few epithelial markers; therefore miss an important portion of mesenchymal cancer cells circulating in blood. In this work, we selected and identified DNA aptamers as specific affinity probes that bind to lung adenocarcinoma cells derived from postoperative tissues.

Effect of a water-maze procedure on the redox mechanisms in brain parts of aged rats.

The Morris water maze (MWM) is a tool for assessment of age-related modulations spatial learning and memory in laboratory rats. In our work was investigated the age-related decline of MWM performance in 11-month-old rats and the effect exerted by training in the MWM on the redox mechanisms in rat brain parts. Young adult (3-month-old) and aged (11-month-old) male rats were trained in the MWM.

[Classification and diagnosis of apraxia].

Apraxia is one of the most frequent clinical presentations of vascular, traumatic, infectious, tumor and neurodegenerative diseases of the brain. However neurologists have difficulties with diagnosis. The author presents a review of current classifications of apraxia and methods of its clinical diagnosis.

Etiology of influenza viruses isolated in Russia from 1998 up to present time.

Influenza epidemic events in Russia from 1998 up to 2005 were associated with the circulation of influenza A (H3N2), A (H1N1) and B viruses. The antigenic analysis revealed that the evolution of A (H3N2) viruses proceeded as following: A/Sydney/05/97-->A/Panama/2007/99-->A/Fujian/411/02-->A/Wellington/01/04; A (H1N1) viruses: A/Bayern/07/95-->A/Bejing/262/95-->A/New Caledonia/20/99; B viruses evolved as two distinct lineages: Victoria- and Yamagata-like viruses. Our results have shown that the evolution in Russia coincided the World trends.

Cell interactions in microgravity: cytotoxic effects of natural killer cells in vitro.

To study cell-to-cell interactions in microgravity we examined the functional activity of natural killer cells on board of the ISS. NK cells are the effector cells with direct cytotoxic activity to oncogenic, virus-infected cells and cells with modified differentiation. Ground-based experiments have shown that the examination of target cell lysis after incubation with NK cells is a simple and informative model for studying the influence of microgravity.

Fertility awareness-based methods for contraception: systematic review of randomized controlled trials.

Context: Fertility awareness-based (FAB) methods of family planning estimate the fertile days of the menstrual cycle whether by observing fertility signs such as cervical secretions and basal body temperature or by monitoring cycle days. The efficacy and acceptability of these methods are unclear.

Methods: We retrieved and analyzed all randomized controlled trials that examined any FAB method used for contraception.

Steroid hormones for contraception in men: systematic review of randomized controlled trials.

Male hormonal contraception has been an elusive goal. Administration of sex steroids to men can shut off sperm production through effects on the pituitary and hypothalamus. However, this approach also decreases production of testosterone, so an "add-back" therapy is needed.

Fertility awareness-based methods for contraception.

Background: "Fertility awareness-based methods" (FAB) of family planning "involve identification of the fertile days of the menstrual cycle, whether by observing fertility signs such as cervical secretions and basal body temperature, or by monitoring cycle days. FAB methods can be used in combination with abstinence or barrier methods during the fertile time" (WHO 2000). Several names have been used to describe this approach to contraception, including "rhythm," "natural family planning" and "periodic abstinence.

Steroid hormones for contraception in men.

Background: Male hormonal contraception has been an elusive goal. Administration of sex steroids to men can shut off sperm production through effects on the pituitary and hypothalamus. However, this approach also decreases production of testosterone, so "add-back" therapy is needed.

Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas.

Objective: This study was designed to evaluate the potential usefulness of the levonorgestrel-releasing intrauterine system (LNG IUS) in treating women with uterine leiomyomas.

Design: Prospective before-and-after study.

Setting: Family planning unit in an academic research institute.

[Effects of short-wave therapy in patients with chronic pyelonephritis].

One hundred and twenty patients (64 men and 56 women, aged 19 to 63) with chronic pyelonephritis were subdivided into two groups: a control group of 30 subjects and an experimental one of 90 subjects. Experimental subjects underwent short wave therapy (460 MHz, 50-60 W, for 8-20 minutes) in the lumbar area. Lumbosacral pain disappeared in 87 out of 90, subjects, intercostal pain in 20 out of 28, headache mitigated in 40 out of 53, asthenia was markedly reduced in 49 out of 50.