[Human gender determination based on the measurements of handprints that are devoid of dermatoglyphic features].

Unlabelled: Gender determination through the use of handprints that are devoid of dermatoglyphic features is associated with either a visual assessment of the shape of the palms and phalanges, or with a comparison of their size with the size of the hands of people of the opposite sex.

Aim: To prove the possibility of gender determination from handprints without papillary ridge features by means of discriminant analysis of their dimensional characteristics, and to compare discriminant models with the results of visual sex classification and data of other authors.

Material And Methods: The handprints of 162 adult subjects (68 males and 94 females), were examined using metrics that are usually not measured on the human body, such as the length of the hand without the distal phalanx of the third finger, the length of the hand from the center of the palm, the width of the ulnar part of the palm, the diagonal width of the palm, and the length of the first beam.

[The importance of handprint morphometry for determining the human body length].

Unlabelled: Handprint morphometry for the purpose of personality identification still remains a relatively novel approach. The methods employed for the measurements are not infrequently difficult to reproduce and therefore cause controversy. The objective of the present study was to introduce the system of methods for the measurement of handprints suitable for the reliable determination of the human body length.

Antithrombotic Protective Effects of Arg-Pro-Gly-Pro Peptide during Emotional Stress Provoked by Forced Swimming Test in Rats.

Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Administration of this peptide in 5 min after swimming test also enhanced anticoagulant, fibrinolytic, and antithrombotic activity of the blood.

[Peptide Regulation of Metabolic Processes under Hypercholesterinemia Conditions of an Organism].

The participation of short glyproline peptides in regulating the metabolic processes of the body has been established. Experimental hypercholesterolemia and the development of metabolic syndrome in rats was caused by including foods with excess animal fat and carbohydrates in the diet, which eventually led to increased levels of cholesterol, triglycerides, and the atherogenic lipoproteins; hypercoagulation; and increased blood sugar. It was noted that glyprolines with different structures possess a unique combined effect on fat and carbohydrate metabolism, normalizing the characteristics of the lipid profile and blood sugar and protecting the organisms of animals from increased blood clotting.

[The reconstruction of the human body length from the wrist size].

The objective of the present study was to develop the regression models for the reconstruction of the human body length from the wrist size taking into consideration the availability of the results of the measurements of the palm fragments or the wrist undergoing muscular contracture. The study included 106 Caucasoid subjects (41 men and 65 women) at the age varying from 18 to 76 years. The following parameters were measured: body length, wrist length, the length of the fingers and phalanges on the back of the hand, palmar length and width, ulnar edge size of the palm.

[Diagnostics of the human sex from the somatometric features in the cases of large-scale catastrophes].

The objective of the present study was to develop the models for sex diagnostics based on the results of measurement of the wrist and its separate parts. It was shown that the best results are obtained using the size of the palm and finger III (from 87.9 to 93% of correct results).

[The application of the nanostructured bioplastic material for the plastic reconstruction of perforations in the nasal septum].

The objective of the present work was to estimate the effectiveness of the application of the nanostructured bioplastic material for the plastic reconstruction of perforations in the nasal septum. A total of 80 patients were recruited for the study. Half of them underwent plastic reconstruction of perforations in the nasal septum with the application of the nanostructured bioplastic material.

Hypoglycemic and anticoagulant effects of tetrapeptide Pro-Gly-Pro-Leu in hypercholesterolemia.

In rats with experimental hypercholesterolemia, 7-fold intranasal administration of the peptide Pro-Gly-Pro-Leu in a dose of 200 μg/kg body weight prevented the increase in blood glucose level and produced an anticoagulant effect.

[The modern concept of the regulatory role of peptides of the glyproline family in the correction of hemostasis system function during development of diabetes mellitus].

The experimental data on the therapeutic and prophylactic antidiabetogenic effect of di-, tri-, and tetrapeptides of the glyproline family with the additional inclusion of arginine or leucine at different positions are presented. The results are obtained using two animal models: with insulin-dependent diabetes mellitus (type 1), and persistent hyperglycemia similar to development of non-insulin-dependent diabetes mellitus (type 2) in humans. It is shown that repeated intranasal administration of Pro-Gly, Pro-Gly-Pro, Pro-Gly-Pro-Arg, Pro-Gly-Arg, Arg-Pro-Gly, Arg-Pro-Gly-Pro, Gly-Pro-Arg, Pro-Arg-Gly, Pro-Gly-Pro-Leu, Leu-Pro-Gly-Pro peptides to rats with hyperglycemia of different etiology led to the combined normoglycemic and anticoagulant effects in the blood plasma.

[Correction of impairments in functions of anticoagulation and insular systems of an organism by the regulatory peptide Leu-Pro-Gly-Pro].

It has been established that fivefold intranasal administration of the peptide Leu-Pro-Gly-Pro (1 mg/kg) to rats with developing refractory hyperglycemia leads to restoration and normalization of the functions of anticoagulation and insular systems. In the blood of experimental animals, there was a decrease in the sugar level and platelet aggregation and an increase in anticoagulant and all kinds of fibrinolytic (total, enzymatic, non-enzymatic, Hageman-dependent) activity.

[Cholesterol-lowering effect of the regulatory peptide Pro-Gly-Pro-Leu].

In the present paper anticoagulant-fibrinolytic effects of the peptide Pro-Gly-Pro-Leu in rats (370-500 g body weight) who consumed fatty foods with excess of saturated fatty acids (wheat flour and bread--35%, sugar--10%, margarine hydrogenated fats, mayonnaise, cheese--35% and offals--10%, cholesterol--1%, dry food--9%) has been established. The duration of the animals on the diet was 15 days. The experimental animals intranasally obtained peptide (200 microg/kg body weight per volume of 0.

Peculiarities of heart rhythm variability in narcotized and immobilized wakeful rats during blockade of calcium channels.

In narcotized rats, verapamil and cinnarizine modified some heart rate variability (HRV) indices and heart rate (HR) indicating up-regulation of parasympathetic tone in contrast to nifedipine that elevated activity of sympathetic subdivision of ANS producing no influence on HR. In wakeful stressed rats, the time-domain and geometric analysis established that verapamil decreased HR and up-regulated sympathetic tone; nifedipine elevated sympathetic tone and produced no effect on HR, while cinnarizine enhanced parasympathetic tone without any effect on HR. Spectrum analysis of HRV revealed probable activation of some other neurohumoral mechanisms by the employed calcium blockers.

Heart rate variability in conscious and anesthetized rats under the action of angiotensin converting enzyme inhibitors.

We studied the effects of three various angiotensin converting enzyme inhibitors (enalapril, lisinopril and quinapril) on heart rhythm variability in anesthetized and immobilized rats. In all cases (except for quinapril in experiments on anesthetized animals), the preparations reduced the total rhythm variability and, according to spectrum analysis, increased activity of the parasympathetic autonomic nervous system to different degrees and decreased sympathetic tone. Quinapril and lisinopril produced the most pronounced influence on heart rhythm in anesthetized rats; enalapril was less potent in this respect.

[Localization of point mutations in the coding part of the VHL gene in clear cell renal cancer].

VHL gene is often inactivated in sporadic clear cell renal cancer (CCRC) due to somatic mutations, and it's germline mutations cause hereditary CCRC--von Hippel-Lindau syndrome. Localization of mutations in VHL, identification of new mutations and their influence on CCRC progression and sensitivity to targeted therapy are actual problems in modern oncogenetics. We have provided search and characterization of mutations in 248 primary CCRC using SSCP-analysis and sequencing.

[A complex of heparin with the peptide Arg-Pro-Gly-Pro and its anticoagulative, fibrinolytic, and hyperglycemia effects].

Heparin was bound to the arginine-containing peptide Arg-Pro-Gly-Pro with the molar ratio of heparin to the peptide 1:1. The complex compound showed antiplatelet, anticoagulative, and fibrin-depolymerization activities. In an in vivo study, in type 2 diabetes progression, a 5-fold intranasal administration of the compound restored both impaired insular and anticlotting functions in rats.

[Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress].

We discovered that simple proline-containing peptides Gly-Pro, Pro-Gly, Pro-Gly-Pro, and semax had an antistress protective effect on the organism appearing as anticoagulation system activation. Repeated intranasal injection of each of these peptides to rats prior to acute immobilization stress prevented a hypercoagulation response to prolonged stress lasting 60 min. At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity.

[Comparative studies of anticoagulant and fibrinolytic effects of glyprolines Gly-Pro and Gly-Pro-Arg in conditions of immobilization stress].

It has been shown that proline-containing peptides Gly-Pro and Gly-Pro-Arg in vitro had anticoagulant and nonenzymatic fibrinolytic activity. It was established that after intranasal introduction of these peptides to a rat, anticoagulant and fibrinolytic activity of enzymatic and nonenzymatic nature increased in the rat blood. The peptide protective effect against hypercoagulation induced by immobilization stress was found after repeated intranasal introduction of each peptide into the animal.

Effect of beta-adrenoblockers on heart rate variability in awake and narcotized rats.

In narcotized rats, beta-adrenoceptor blockers changed all parameters of heart rate variability indicating up-regulation of parasympathetic activity and down-regulation of the sympathetic one. In immobilized awake rats, the temporal and geometrical parameters varied similarly, while spectral analysis indicated possible activation of other neurohumoral mechanisms against the background of beta-blocker treatment.

[Prognosis of basic somatic characteristics of humans in expert examination of fragments of human body].

To develop a method of assessing human body somatometric parameters by its fragmentation, we used individual data on the series G. van Vark (1975) from corpses of 62 males and 39 females aged from 23 to 95 years. Statistical processing with SPSS package calculated regression equations allowing prediction of head size, length of the upper and lower limbs and their segments.

[Stabiltiy and barries function provided by sanitary protective zone of radioactive waste neutralization site, according to data obtained through geoinformative technologies].

The authors defined a radioactive waste neutralization and disposal site as a complex of industrial chambers with used territory of ground with burial places, buffer sanitary protection zone and observation zone. This area is a complicated geotechnical zone where natural communities develop under chronic exposure to natural and artificial radionuclides coming from both global and technogenic sources. Using geoinformative technologies of radioecologic safety, the authors evaluated protective functions of buffer zone, its biopotential and stability to specific type of nature management.

[Effect of thyrotropin-releasing hormone and its synthetic analogue digipramine on certain hemostatic indices in vitro and in vivo].

The effect of neuropeptide thyrotropin-releasing hormone (TRH) and its synthetic analogue digipramine on certain indices of the blood coagulation system and fibrinolysis were studied in vitro and in vivo. The peptides added to the pool of normal rat plasma at 10(-10) to 10(-3) M increased the procoagulant activity but had virtually no effect on fibrinolysis. Intravenous administration of TRH and digipramine increased the procoagulant activity of the blood and thrombocyte aggregation but decreased fibrinolysis; digipramine had a more pronounced effect on the coagulation potential of the blood and a less pronounced effect on fibrinolytic indices as compared to TRH.

[Contents of vitamin C, E, B6, beta-carotene and food fibers in of mushrooms].

For specification and entering of the data in to Tables of a chemical compound of foodstuff definition of the content of vitamins C, E, B6 beta-carotene and dietary fibers in some kinds of the mushrooms collected in woods of Moscow suburbs was carried out. The received data testify to high enough content in them of vitamin C, especiale in white mushrooms and "fox" 24.0 and 28.

[Application of the discriminant analysis for the assessment of human somatotype using the long bones of extremities].

Measurements were made on the basis of the osteological collection of the chair for anthropology, Moscow State University (70 cases), and on the basis of a series of skeletons (10 cases) from among burial places of the Novospassk Monastery (males aged above 18-20). Eleven sizes of Martin program (length, diaphysis circumference and epiphysis width) were fixed onto the humerus, radial, femoral and shin bones. Simultaneously, the development of the osseous relief elements in the above bones (a total of 18 signs in each skeleton) was evaluated by Fedosova program.